The ability to taste bitter thiourea compounds, such as phenylthiocarbamide (PTC) and 6--propylthiouracil (PROP), is inherited. Polymorphisms in the bitter-taste receptor explain the majority of phenotypic variation in the PROP phenotype. It has been hypothesized that the PROP phenotype is a marker for perception of a variety of chemosensory experiences. In this review, we discuss studies that have investigated the relationship between bitter-taste response and dietary behaviors and chronic health in children. Investigators have hypothesized that children who are PROP tasters have lower liking and consumption of bitter foods, such as cruciferous vegetables. Additionally, several studies suggest that children who are unable to taste PROP (i.e., nontasters) like and consume more dietary fat and are prone to obesity. The relationship between the PROP phenotype and obesity is influenced by multiple confounders, including sex, food access, ethnicity, and socioeconomic status. Future studies that adjust for these variables are needed.


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Literature Cited

  1. Adair LS. 1.  2008. Child and adolescent obesity: epidemiology and developmental perspectives. Physiol. Behav. 94:8–16 [Google Scholar]
  2. Anliker J, Bartoshuk L, Ferris A, Hooks L. 2.  1991. Children's food preferences and genetic sensitivity to the bitter taste of 6-n-propylthiouracil (PROP). Appetite 54:316–20 [Google Scholar]
  3. Bajec M, Pickering G. 3.  2008. Thermal taste, PROP responsiveness, and perception of oral sensations. Physiol. Behav. 95:581–90 [Google Scholar]
  4. Baranowski J, Baranowski T, Beltran A, Watson K, Jago R. 4.  et al. 2009. 6-n-Propylthiouracil sensitivity and obesity status among ethnically diverse children. Public Health Nutr. 13:1587–92 [Google Scholar]
  5. Baranowski T, Baranowski J, Watson K, Jago R, Islam N. 5.  et al. 2011. 6-n-Propylthiouracil taster status not related to reported cruciferous vegetable intake among ethnically diverse children. Nutr. Res. 31:594–600 [Google Scholar]
  6. Bartoshuk LM. 6.  1994. PTC/PROP tasting: anatomy, psychophysics, and sex effects. Physiol. Behav. 56:1165–71 [Google Scholar]
  7. Bartoshuk LM. 7.  1996. Supertasting, earaches and head injury: Genetics and pathology alter our taste worlds. Neurosci. Biobehav. Rev. 20:79–87 [Google Scholar]
  8. Bartoshuk LM. 8.  2000. Comparing sensory experiences across individuals: recent psychophysical advances illuminate genetic variation in taste perception. Chem. Senses 25:447–60 [Google Scholar]
  9. Bartoshuk LM, Duffy V, Lucchina L, Prutkin J, Fast K. 9.  1998. PROP (6-n-propylthiouracil) supertasters and the saltiness of NaCl. Ann. N. Y. Acad. Sci. 855:793–96 [Google Scholar]
  10. Bartoshuk LM, Duffy VB, Green BG, Hoffman HJ, Ko CW. 10.  et al. 2004. Valid across-group comparisons with labeled scales: the gLMS versus magnitude matching. Physiol. Behav. 82:109–14 [Google Scholar]
  11. Basson M, Bartoshuk L, Dichello S, Panzini L, Weiffenbach J, Duffy V. 11.  2005. Association between 6-n-propylthiouracil (PROP) bitterness and colonic neoplasms. Digest. Dis. Sci. 50:483–89 [Google Scholar]
  12. Bauer F, Elbers CC, Adan RAH, Loos RJF, Onland-Moret NC. 12.  et al. 2009. Obesity genes identified in genome-wide association studies are associated with adiposity measures and potentially with nutrient-specific food preference. Am. J. Clin. Nutr. 90:951–59 [Google Scholar]
  13. Behrens M, Foerster S, Staehler F, Raguse J, Meyerhof W. 13.  2007. Gustatory expression pattern of the human TAS2R bitter receptor gene family reveals a heterogeneous population of bitter responsive taste receptor cells. J. Neurosci. 27:12630–40 [Google Scholar]
  14. Behrens M, Gunn H, Ramos P, Meyerhof W, Wooding S. 14.  2013. Genetic, functional, and phenotypic diversity in TAS2R38-mediated bitter taste perception. Chem. Senses 38:475–84 [Google Scholar]
  15. Bell K, Tepper B. 15.  2006. Short-term vegetable intake by young children classified by 6-n-propylthiouracil bitter-taste phenotype. Am. J. Clin. Nutr. 84:245–51 [Google Scholar]
  16. Benzencon C, Le Coutre J, Damak S. 16.  2007. Taste-signaling proteins are coexpressed in solitary intestinal epithelial cells. Chem. Senses 32:41–49 [Google Scholar]
  17. Betz J, Fox W. 17.  1994. High-performance liquid chromatographic determination of glucosinolates in Brassica vegetables. Am. Chem. Soc. 546:181–96 [Google Scholar]
  18. Birch LL. 18.  1979. Preschool children's food preferences and consumption patterns. J. Nutr. Educ. 11:189–92 [Google Scholar]
  19. Birch LL, Sullivan S. 19.  1991. Measuring children's food preferences. J. School Health 61:1245–51 [Google Scholar]
  20. Blakeslee A, Fox A. 20.  1932. Our different taste worlds. J. Heredity 23:97–107 [Google Scholar]
  21. Blakeslee A, Salmon M. 21.  1931. Odor and taste blindness. Eugen. News 16:105–10 [Google Scholar]
  22. Borazon E, Villarino B, Magbuhat R, Sabandal M. 22.  2012. Relationship of PROP (6-n-propylthiouracil) taster status with body mass index, food preferences, and consumption of Filipino adolescents. Food Res. Int. 47:229–35 [Google Scholar]
  23. Bouthoorn S, van Lenthe F, Kiefte-de Jong J, Taal H, Wijtzes A. 23.  et al. 2014. Genetic taste blindness to bitter and body composition in childhood: a Mendelian randomization design. Int. J. Obes. 38:1005–10 [Google Scholar]
  24. Boyd W. 24.  1950. Taste reactions to antithyroid substances. Science 112:153 [Google Scholar]
  25. Bravo L. 25.  1998. Polyphenols: chemistry, dietary sources, metabolism, and nutritional significance. Nutr. Rev. 56:317–33 [Google Scholar]
  26. Bufe B, Kuhn C, Reed D, Tharp C, Slack J. 26.  et al. 2005. The molecular basis of individual differences in phenylthiocarbamide and propylthiouracil bitterness perception. Curr. Biol. 15:1–20 [Google Scholar]
  27. Burd C, Senerat A, Chambers E, Keller K. 27.  2013. PROP taster status interacts with the built environment to influence children's food acceptance and body weight status. Obesity 21:786–94 [Google Scholar]
  28. Cabras T, Melis M, Castagnola M, Padiglia A, Tepper BJ. 28.  et al. 2012. Responsiveness to 6-n-propylthiouracil (PROP) is associated with salivary levels of two specific basic proline-rich proteins in humans. PLOS ONE 7:e30962 [Google Scholar]
  29. Calo C, Padiglia A, Zonza A, Corrias L, Contu P. 29.  et al. 2011. Polymorphisms in TAS2R38 and the taste bud trophic factor, gustin gene co-operate in modulating PROP taste phenotype. Physiol. Behav. 104:1065–71 [Google Scholar]
  30. Campbell MC, Ranciaro A, Froment A, Hirbo J, Omar S. 30.  et al. 2011. Evolution of functionally diverse alleles associated with PTC bitter taste sensitivity in Africa. Mol. Biol. Evol. 29:1141–53 [Google Scholar]
  31. Chale-Rush A, Burgess JR, Mattes RD. 31.  2007. Evidence for human orosensory (taste?) sensitivity to free fatty acids. Chem. Senses 32:423–31 [Google Scholar]
  32. Chauhan J, Hawrysh Z. 32.  1988. Suprathreshold sour taste intensity and pleasantness perception with age. Physiol. Behav. 43:601–7 [Google Scholar]
  33. Collaku A, Rankinen T, Rice T, Leon AS, Rao DC. 33.  et al. 2004. A genome-wide linkage scan for dietary energy and nutrient intakes: the Health, Risk Factors, Exercise Training, and Genetics (HERITAGE) Family Study. Am. J. Clin. Nutr. 79:881–86 [Google Scholar]
  34. Desor JA, Beauchamp GK. 34.  1987. Longitudinal changes in sweet preferences in humans. Physiol. Behav. 39:639–41 [Google Scholar]
  35. Dotson C, Zhang LH, Xu H, Shin YV, Vigues S. 35.  et al. 2008. Bitter taste receptors influence glucose homeostasis. PLOS ONE 3:e3974 [Google Scholar]
  36. Drayna D, Coon H, Kim U-K, Elsner T, Cromer K. 36.  et al. 2003. Genetic analysis of a complex trait in the Utah Genetic Reference Project: a major locus for PTC taste ability on chromosome 7q and a secondary locus on chromosome 16p. Hum. Genet. 112:567–72 [Google Scholar]
  37. Drewnowski A, Henderson S, Cockroft J. 37.  2007. Genetic sensitivity to 6-n-propylthiouracil has no influence on dietary patterns, body mass indexes, or plasma lipid profiles of women. J. Am. Diet. Assoc. 107:1340–48 [Google Scholar]
  38. Drewnowski A, Henderson S, Hann C, Berg W, Ruffin M. 38.  2000. Genetic taste markers and preferences for vegetables and fruit of female breast cancer patients. J. Am. Diet. Assoc. 100:191–97 [Google Scholar]
  39. Drewnowski A, Henderson S, Shore A. 39.  1997. Taste responses to naringin, a flavonoid, and the acceptance of grapefruit juice area related to genetic sensitivity to 6-n-propylthiouracil. Am. J. Clin. Nutr. 66:391–97 [Google Scholar]
  40. Drewnowski A, Henderson SA, Shore AB, Barratt-Fornell A. 40.  1997. Nontasters, tasters, and supertasters of 6-n-propylthiouracil (PROP) and hedonic response to sweet. Physiol. Behav. 62:649–55 [Google Scholar]
  41. Drewnowski A, Kristal A, Cohen J. 41.  2001. Genetic taste responses to 6-n-propylthiouracil among adults: a screening tool for epidemiological studies. Chem. Senses 26:483–89 [Google Scholar]
  42. Duffy B, Peterson J, Bartoshuk L. 42.  2004. Associations between taste genetics, oral sensation and alcohol intake. Physiol. Behav. 82:435–45 [Google Scholar]
  43. Duffy V, Bartoshuk LM. 43.  2000. Food acceptance and genetic variation in taste. J. Am. Diet. Assoc. 100:47–55 [Google Scholar]
  44. Duffy V, Davidson A, Kidd J, Kidd K, Speed W. 44.  2004. Bitter receptor gene (TAS2R38), 6-n-propylthiouracil (PROP) bitterness and alcohol intake. Alcohol. Clin. Exp. Res. 28:1629–37 [Google Scholar]
  45. Duffy V, Hayes J, Davidson A, Kidd J, Kidd K, Bartoshuk L. 45.  2010. Vegetable intake in college-aged adults is explained by oral sensory phenotypes and TAS2R38 genotype. Chemosens. Percept. 3:137–48 [Google Scholar]
  46. Duffy V, Lucchina L, Bartoshuk L. 46.  2004. Genetic variation in taste: potential biomarker for cardiovascular disease?. See Ref. 112 195–228
  47. Essick G, Chopra A, Guest S, McGlone F. 47.  2003. Lingual tactile acuity, taste perception, and the density and diameter of fungiform papillae in female subjects. Physiol. Behav. 80:289–302 [Google Scholar]
  48. Febbraio M, Abumrad NA, Hajjar DP, Sharma K, Cheng W. 48.  et al. 1999. A null mutation in murine CD36 reveals an important role in fatty acid and lipoprotein metabolism. J. Biol. Chem. 274:19055–62 [Google Scholar]
  49. Feeney E, Hayes J. 49.  2014. Exploring associations between taste perception, oral anatomy and polymorphisms in the carbonic anhydrase (gustin) gene CA6. Physiol. Behav. 128:148–54 [Google Scholar]
  50. Feeney E, O'Brien S, Scannell A, Markey A, Gibney ER. 50.  2011. Genetic variation in taste perception: Does it have a role in healthy eating?. Proc. Nutr. Soc. 70:135–43 [Google Scholar]
  51. Fenwick G, Heaney R, Mullin W. 51.  1983. Glucosinolates and their breakdown products in food and food plants. Crit. Rev. Food. Sci. Nutr. 18:123–201 [Google Scholar]
  52. Fischer M, Cruickshanks K, Schubert C, Pinto A, Klein R. 52.  et al. 2013. Factors related to fungiform papillae density: the Beaver Dam Offspring Study. Chem. Senses 38:669–77 [Google Scholar]
  53. Fischer R, Griffin F, England S, Garn S. 53.  1961. Taste thresholds and food dislikes. Nature 191:1328 [Google Scholar]
  54. Fisher JO, Mennella JA, Hughes SO, Yan L, Mendoza PM, Patrick H. 54.  2012. Offering “dip” promotes intake of a moderately-liked raw vegetable among preschoolers with genetic sensitivity to bitterness. J. Am. Diet. Assoc. 112:235–45 [Google Scholar]
  55. Fisher R, Ford E, Huxley J. 55.  1939. Taste-testing the anthropoid apes. Nature 144:750 [Google Scholar]
  56. Garneau N, Nuessle T, Sloan M, Santorico S, Coughlin B, Hayes J. 56.  2014. Crowdsourcing taste research: genetic and phenotypic predictors of bitter taste perception as a model. Front. Integr. Neurosci. 8:33 [Google Scholar]
  57. Glanville E, Kaplan A. 57.  1965. Food preference and sensitivity of taste for bitter compounds. Nature 205:851–52 [Google Scholar]
  58. Golding J, Steer C, Emmett P, Bartoshuk LM, Horwood J, Smith GD. 58.  2009. Associations between the ability to detect a bitter taste, dietary behavior, and growth: a preliminary report. Ann. N. Y. Acad. Sci. 1170:553–57 [Google Scholar]
  59. Goldstein G, Daun H, Tepper B. 59.  2005. Adiposity in middle-aged women is associated with genetic taste blindness to 6-n-propylthiouracil. Obes. Res. 13:1017–23 [Google Scholar]
  60. Goldstein G, Daun H, Tepper B. 60.  2007. Influence of PROP taster status and maternal variables on energy intake and body weight of pre-adolescents. Physiol. Behav. 90:809–17 [Google Scholar]
  61. Greene L. 61.  1973. Physical growth and development, neurological maturation and behavioral functioning in two Ecuadorian Andean communities in which goiter is endemic. Am. J. Phys. Anthropol. 38:119–34 [Google Scholar]
  62. Guo SW. 62.  2001. The genetics of phenylthiocarbamide perception. Ann. Hum. Biol. 28:111–42 [Google Scholar]
  63. Hartvig D, Hausner H, Wendin K, Bredie W. 63.  2014. Quinine sensitivity influences the acceptance of sea-buckthorn and grapefruit juices in 9- to 11-year-old children. Appetite 74:70–78 [Google Scholar]
  64. Hayes J, Bartoshuk L, Kidd J, Duffy V. 64.  2008. Supertasting and PROP bitterness depends on more than the TAS2R38 gene. Chem. Senses 33:255–65 [Google Scholar]
  65. Hayes J, Duffy V. 65.  2007. Revisiting sugar-fat mixtures: Sweetness and creaminess vary with phenotypic markers of oral sensation. Chem. Senses 32:225–36 [Google Scholar]
  66. Hayes J, Duffy V. 66.  2008. Oral sensory phenotype identifies level of fat and sugar required for maximal liking. Physiol. Behav. 95:77–87 [Google Scholar]
  67. Hayes J, Feeney E, Allen A. 67.  2013. Do polymorphisms in chemosensory genes matter for human ingestive behavior?. Food Qual. Pref. 30:202–16 [Google Scholar]
  68. Hedge AM. 68.  2008. Genetic sensitivity to 6-n-propylthiouracil (PROP) as a screening tool for obesity and dental caries in children. J. Clin. Pediatr. Dent. 33:107–11 [Google Scholar]
  69. Jang H, Kokrashvili Z, Theodorakis M, Carlson O, Kim B. 69.  et al. 2007. Gut-expressed gustducin and taste receptors regulate secretion of glucagon-like peptide-1. PNAS 104:15069–74 [Google Scholar]
  70. Jannsen S, Laermans J, Verhulst P, Thijs T, Tack J. 70.  et al. 2011. Bitter taste receptors and α-gustducin regulate the secretion of ghrelin with functional effects on food intake and gastric emptying. PNAS 108:2094–99 [Google Scholar]
  71. Johnson FE, Hertzog KP, Malina RM. 71.  1966. Phenylthiocarbamide taste sensitivity and its relationship to growth variation. Am. J. Phys. Anthropol. 24:253–56 [Google Scholar]
  72. Keller KL. 72.  2002. Genetic sensitivity to 6-n-propylthiouracil (PROP): associations with food acceptance, intake, and body weight in preschool children PhD Thesis, Rutgers Univ., New Brunswick, NJ [Google Scholar]
  73. Keller KL. 73.  2012. Common variants in the CD36 gene are associated with oral fat perception, fat preferences, and obesity in African Americans. Obesity 20:1066–73 [Google Scholar]
  74. Keller KL. 74.  2012. Genetic influences on oral fat perception and preference. Presented at the symposium “The Taste for Fat: New Discoveries on the Role of Fat in Sensory Perception, Metabolism, Sensory Pleasure and Beyond” held at the Institute of Food Technologists 2011 Annual Meeting, New Orleans, La., June 12, 2011. J. Food Sci. 77:S143–47 [Google Scholar]
  75. Keller KL, Olsen A, Cravener TL, Bloom R, Chung WK. 75.  et al. 2014. Bitter taste phenotype and body weight predict children's selection of sweet and savory foods at a palatable test-meal. Appetite 77:115–23 [Google Scholar]
  76. Keller KL, Reid A, MacDougall MC, Cassano H, Song JL. 76.  et al. 2010. Sex differences in the effects of bitter thiourea sensitivity on body weight in 4–6-year-old children. Obesity 18:1194–200 [Google Scholar]
  77. Keller KL, Steinmann L, Nurse RJ, Tepper BJ. 77.  2002. Genetic taste sensitivity to 6-n-propylthiouracil influences food preference and reported intake in preschool children. Appetite 38:3–12 [Google Scholar]
  78. Keller KL, Tepper BJ. 78.  2004. Inherited taste sensitivity to 6-n-propylthiouracil in diet and body weight in children. Obes. Res. 12:904–12 [Google Scholar]
  79. Kildegaard H, Tonning E, Thybo A. 79.  2011. Preference, liking and wanting for beverages in children aged 9–14 years. Role of sourness perception, chemical composition and background variables. Food Qual. Pref. 22:620–27 [Google Scholar]
  80. Kim U, Jorgenson E, Coon H, Leppert M, Risch N, Drayna D. 80.  2003. Positional cloning of the human quantitative trait locus underlying taste sensitivity to phenylthiocarbamide. Science 299:1221–24 [Google Scholar]
  81. Kim U, Wooding S, Ricci D, Jorde L, Drayna D. 81.  2005. Worldwide haplotype diversity and coding sequence variation at human bitter taste receptor loci. Hum. Mutat. 26:199–204 [Google Scholar]
  82. Lawless H. 82.  1980. A comparison of different methods used to assess sensitivity to the taste of phenylthiocarbamide (PTC). Chem. Senses 5:247–56 [Google Scholar]
  83. Liang L, Sakimura J, May D, Breen C, Driggin E. 83.  et al. 2012. Fat discrimination: a phenotype with potential implications for studying fat intake behaviors and obesity. Physiol. Behav. 105:470–75 [Google Scholar]
  84. Lin B. 84.  2003. Caries experience in children with various genetic sensitivity levels to the bitter taste of 6-n-propylthiouracil (PROP): a pilot study. Pediatr. Dent. 25:37–42 [Google Scholar]
  85. Lipchock S, Mennella J, Spielman A, Reed D. 85.  2013. Human bitter perception correlates with bitter receptor messenger RNA expression in taste cells. Am. J. Clin. Nutr. 98:1136–43 [Google Scholar]
  86. Lipchock S, Reed D, Mennella J. 86.  2012. Relationship between bitter-taste receptor genotype and solid medication formulation usage among young children: a retrospective analysis. Clin. Ther. 34:728–33 [Google Scholar]
  87. Looy H. 87.  1992. Hedonic response of sucrose likers and dislikers to other gustatory stimuli. Physiol. Behav. 52:219–25 [Google Scholar]
  88. Looy H, Weingarten HP. 88.  1992. Facial expressions and genetic sensitivity to 6-n-propylthiouracil predict hedonic response to sweet. Physiol. Behav. 52:75–82 [Google Scholar]
  89. Lumeng J, Cardinal T, Sitto J, Kannan S. 89.  2008. Ability to taste 6-n-propylthiouracil and BMI in low-income preschool-aged children. Obesity 16:1522–28 [Google Scholar]
  90. Ly A, Drewnowski A. 90.  2001. PROP (6-n-propylthiouracil) tasting and sensory responses to caffeine, sucrose, neohesperidin dihydrochalcone and chocolate. Chem. Senses 26:41–47 [Google Scholar]
  91. Mace O, Affleck J, Patel N, Kellett G. 91.  2007. Sweet taste receptors in rat small intestine stimulate glucose absorption through apical GLUT2. J. Physiol. 582:379–92 [Google Scholar]
  92. Melis M, Atzori E, Cabras S, Zonza A, Calò C. 92.  et al. 2013. The gustin (CA6) gene polymorphism, rs2274333 (A/G), as a mechanistic link between PROP tasting and fungiform taste papilla density and maintenance. PLOS ONE 8:e74151 [Google Scholar]
  93. Mennella JA, Bobowski NK. 93.  2015. The sweetness and bitterness of childhood: Insights from basic research on taste preferences. Physiol. Behav. 152:Part B502–7 [Google Scholar]
  94. Mennella JA, Pepino MY, Duke FF, Reed DR. 94.  2010. Age modifies the genotype-phenotype relationship for the bitter receptor TAS2R38. BMC Genet. 11:60–69 [Google Scholar]
  95. Mennella JA, Pepino MY, Reed DR. 95.  2005. Genetic and environmental determinants of bitter perception and sweet preferences. Pediatrics 115:216–22 [Google Scholar]
  96. Mennella JA, Reed DR, Mathew PS, Roberts KM, Mansfield CJ. 96.  2014. “A spoonful of sugar helps the medicine go down”: bitter masking by sucrose among children and adults. Chem. Senses 40:17–25 [Google Scholar]
  97. Mennella JA, Roberts KM, Mathew PS, Reed DR. 97.  2015. Children's perceptions about medicines: individual differences and taste. BMC Pediatr. 15:130–36 [Google Scholar]
  98. Merton B. 98.  1958. Taste sensitivity to PTC in 60 Norwegian families with 176 children; confirmation of the hypothesis of single gene inheritance. Acta Genet. Stat. Med. 8:114–28 [Google Scholar]
  99. Meyerhof W, Batram C, Kuhn C, Brockhoff A, Chudoba E. 99.  et al. 2010. The molecular receptive ranges of human TAS2R bitter taste receptors. Chem. Senses 35:157–70 [Google Scholar]
  100. Nasser JA, Kissileff HR, Boozer CN, Chou CJ, Pi-Sunyer FX. 100.  2001. PROP taster status and oral fatty acid perception. Eat. Behav. 2:237–45 [Google Scholar]
  101. O'Brien S, Feeney E, Scannell A, Markey A, Gibney E. 101.  2013. Bitter taste perception and dietary intake patterns in Irish children. J. Nutrigenetics Nutrigenomics 6:43–58 [Google Scholar]
  102. Oftedal KN, Tepper BJ. 102.  2013. Influence of the PROP bitter taste phenotype and eating attitudes on energy intake and weight status in pre-adolescents: a 6-year follow-up study. Physiol. Behav. 118:103–11 [Google Scholar]
  103. Ogden CL. 103.  2012. Prevalence of obesity and trends in body mass index among US children and adolescents, 1999–2010. JAMA 307:483–90 [Google Scholar]
  104. Olson JM, Boehnke M, Neiswanger K, Roche AF, Siervogel RM, MacCluer JW. 104.  1989. Alternative genetic models for the inheritance of the phenylthiocarbamide taste deficiency. Genet. Epidemiol. 6:423–34 [Google Scholar]
  105. Padiglia A, Zonza A, Atzori E, Chillotti C, Calo MC. 105.  et al. 2010. Sensitivity to 6-n-propylthiouracil (PROP) is associated with gustin (carbonic anhydrase VI) gene polymorphism, salivary zinc, and body mass index in humans. Am. J. Clin. Nutr. 92:539–45 [Google Scholar]
  106. Pepino MY. 106.  2005. Factors contributing to individual differences in sucrose preference. Chem. Senses 30:Suppl. 1i319–20 [Google Scholar]
  107. Peterson JM, Bartoshuk LM, Duffy VB. 107.  1999. Intensity and preference for sweetness is influenced by genetic taste variation. J. Am. Diet. Assoc. 99:Suppl.A28 [Google Scholar]
  108. Pidamale R, Sowmya B, Thomas A, Jose T. 108.  2012. Genetic sensitivity to bitter taste of 6-n propylthiouracil: a useful diagnostic aid to detect early childhood caries in pre-school children. Indian J. Hum. Genet. 18:101–5 [Google Scholar]
  109. Pidamale R, Sowmya B, Thomas A, Jose T, Madhusudan KK, Prasad G. 109.  2012. Association between early childhood caries, Streptococcus mutans level and genetic sensitivity levels to the bitter taste of, 6-N propylthiouracil among the children below 71 months of age. Dent. Res. J. 9:730–34 [Google Scholar]
  110. Prescott J, Bartoshuk L, Prutkin J. 110.  2004. 6-n-Propylthiouracil tasting and the perception of nontaste oral sensations. See Ref. 112 89–104
  111. Prescott J, Swain-Campbell N. 111.  2000. Responses to repeated oral irritation by capsaicin, cinnamaldehyde and ethanol in PROP tasters and non-tasters. Chem. Senses 25:239–46 [Google Scholar]
  112. Prescott J, Tepper B. 112.  2004. Genetic Variation in Taste Sensitivity New York: Marcel Dekker [Google Scholar]
  113. Prutkin J, Duffy V, Etter L, Fast K, Gardner E. 113.  et al. 2000. Genetic variation and inferences about perceived taste intensity in mice and men. Physiol. Behav. 69:161–73 [Google Scholar]
  114. Reed DR, Bachmanov AA, Beachamp GK, Tordoff MG, Price RA. 114.  1997. Heritable variation in food preferences and their contribution to obesity. Behav. Genet. 27:373–87 [Google Scholar]
  115. Reed DR, Tanaka T, McDaniel AH. 115.  2006. Diverse tastes: genetics of sweet and bitter perception. Physiol. Behav. 88:215–26 [Google Scholar]
  116. Rozengurt E. 116.  2006. Taste receptors in the gastrointestinal tract. I. Bitter taste receptors and α-gustducin in the mammalian gut. Am. J. Physiol. Gastrointest. Liver Physiol. 291:G171–77 [Google Scholar]
  117. Rozengurt E, Sternini C. 117.  2007. Taste receptor signaling in the mammalian gut. Curr. Opin. Pharmacol. 7:557–62 [Google Scholar]
  118. Rozin P. 118.  1976. Psychobiological and cultural determinants of food choice. Dahleon Workshop on Appetite and Food Intake T Silverstone 285–312 Berlin: Dahleon Konferenzen [Google Scholar]
  119. Rupesh SS. 119.  2006. Genetic sensitivity to the bitter taste of 6-n propylthiouracil: a new risk determinant for dental caries in children. J. Indian Soc. Pedod. Prev. Dent. 24:63–68 [Google Scholar]
  120. Shahbake M, Hutchinson I, Laing D, Jinks A. 120.  2005. Rapid quantitative assessment of fungiform papillae density in the human tongue. Brain Res. 1052:196–201 [Google Scholar]
  121. Sharma K, Kaur G. 121.  2014. PTC bitter taste genetic polymorphism, food choices, physical growth in body height and body fat related traits among adolescent girls from Kangra Valley, Himachal Pradesh (India). Ann. Hum. Biol. 41:29–39 [Google Scholar]
  122. Shetty V, Pooja B, Hegde AM. 122.  2014. PROP test: prediction of caries risk by genetic taste perception among the visually impaired children. Spec. Care Dent. 34:34–40 [Google Scholar]
  123. Steiner JE. 123.  1977. Facial expressions of the neonate infant indicating the hedonics of food-related chemical stimuli. Taste and Development: The Genesis of Sweet Preference JM Weiffenbach 173–88 Bethesda, MD: US Dep. Health Educ. Welf., Public Health Serv., Natl. Inst. Health [Google Scholar]
  124. Steiner JE, Glaser D, Hawilo ME, Berridge KC. 124.  2001. Comparative expression of hedonic impact: affective reactions to taste by human infants and other primates. Neurosci. Biobehav. Rev. 25:53–74 [Google Scholar]
  125. Stewart JE, Feinle-Bisset C, Golding M, Delahunty C, Clifton PM, Keast RSJ. 125.  2010. Oral sensitivity to fatty acids, food consumption and BMI in human subjects. Br. J. Nutr. 104:145–52 [Google Scholar]
  126. Stewart JE, Seimon RV, Otto B, Keast RSJ, Clifton PM, Feinle-Bisset C. 126.  2011. Marked differences in gustatory and gastrointestinal sensitivity to oleic acid between lean and obese men. Am. J. Clin. Nutr. 93:703–11 [Google Scholar]
  127. Tepper BJ. 127.  1998. 6-n-Propylthiouracil: a genetic marker for taste, with implications for food preference and dietary habits. Am. J. Hum. Genet. 63:1271–76 [Google Scholar]
  128. Tepper BJ. 128.  1999. Does genetic taste sensitivity to PROP influence food preferences and body weight?. Appetite 32:422 [Google Scholar]
  129. Tepper BJ, Banni S, Melis M, Crnjar R, Tomassini Barbarossa I. 129.  2014. Genetic sensitivity to the bitter taste of 6-n-propylthiouracil (PROP) and its association with physiological mechanisms controlling body mass index (BMI). Nutrients 6:3363–81 [Google Scholar]
  130. Tepper BJ, Christensen CM, Cao J. 130.  2001. Development of brief methods to classify individuals by PROP taster status. Physiol. Behav. 73:571–77 [Google Scholar]
  131. Tepper BJ, Nurse RJ. 131.  1997. Fat perception is related to PROP taster status. Physiol. Behav. 61:949–54 [Google Scholar]
  132. Tepper BJ, Nurse RJ. 132.  1998. PROP taster status is related to fat perception and preference. Ann. N. Y. Acad. Sci. 30:802–4 [Google Scholar]
  133. Tepper BJ, Ullrich NV. 133.  2002. Influence of genetic taste sensitivity to 6-n-propylthiouracil (PROP), dietary restraint and disinhibition on body mass index in middle-aged women. Physiol. Behav. 75:305–12 [Google Scholar]
  134. Tsuji M, Nakamura K, Tamai Y, Wada K, Sahashi Y. 134.  et al. 2012. Relationship of intake of plant-based foods with 6-n-propylthiouracil sensitivity and food neophobia in Japanese preschool children. Eur. J. Clin. Nutr. 66:47–52 [Google Scholar]
  135. Turnbull B, Matisoo-Smith E. 135.  2002. Taste sensitivity to 6-n-propylthiouracil predicts acceptance of bitter-tasting spinach in 3–6-y-old children. Am. J. Clin. Nutr. 6:1101–5 [Google Scholar]
  136. Tzioumis E, Adair LS. 136.  2014. Childhood dual burden of under- and overnutrition in low- and middle-income countries: a critical review. Food Nutr. Bull. 35:230–43 [Google Scholar]
  137. Verhoeven D, Verhagen H, Goldbolm R, van den Brandt P, van Poppel G. 137.  1997. A review of mechanisms underlying anti-carcinogenicity by brassica vegetables. Chem. Biol. Interact. 103:79–129 [Google Scholar]
  138. Wheatcraft P. 138.  1972. Toxicity of the taste testing compound phenylthiocarbamide. Nature 235:93–94 [Google Scholar]
  139. Whissell-Buechy D, Wills C. 139.  1989. Male and female correlations for taster (P.T.C.) phenotypes and rate of adolescent development. Ann. Hum. Biol. 16:131–46 [Google Scholar]
  140. Wooding S. 140.  2006. Phenylthiocarbamide: a 75-year adventure in genetics and natural selection. Genetics 172:2015–23 [Google Scholar]
  141. Wooding S, Gunn H, Ramos P, Thalmann S, Xing C, Meyerhof W. 141.  2010. Genetics and bitter taste responses to goitrin, a plant toxin found in vegetables. Chem. Senses 35:685–92 [Google Scholar]
  142. Yeomans MR, Tepper BJ, Rietzschel J, Prescott J. 142.  2007. Human hedonic responses to sweetness: role of taste genetics and anatomy. Physiol. Behav. 91:264–73 [Google Scholar]

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