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Annual Review of Pharmacology and Toxicology

Volume 64, 2024

Translational In Vivo Assays in Behavioral Biology

Abstract

The failure of preclinical research to advance successful candidate medications in psychiatry has created a paradigmatic crisis in psychiatry. The Research Domain Criteria (RDoC) initiative was designed to remedy this situation with a neuroscience-based approach that employs multimodal and cross-species in vivo methodology to increase the probability of translational findings and, consequently, drug discovery. The present review underscores the feasibility of this methodological approach by briefly reviewing, first, the use of multidimensional and cross-species methodologies in traditional behavioral pharmacology and, subsequently, the utility of this approach in contemporary neuroimaging and electrophysiology research—with a focus on the value of functionally homologous studies in nonhuman and human subjects. The final section provides a brief review of the RDoC, with a focus on the potential strengths and weaknesses of its domain-based underpinnings. Optimistically, this mechanistic and multidimensional approach in neuropsychiatric research will lead to novel therapeutics for the management of neuropsychiatric disorders.

Keyword(s): behavioral electrophysiology, behavioral neuroimaging, behavioral pharmacology, drug discovery, RDoC, Research Domain Criteria, translational research
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/content/journals/10.1146/annurev-pharmtox-051921-093711
2024-01-23
2024-04-28
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/content/journals/10.1146/annurev-pharmtox-051921-093711
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Translational In Vivo Assays in Behavioral Biology
Annual Review of Pharmacology and Toxicology 64, 435 (2024); https://doi.org/10.1146/annurev-pharmtox-051921-093711
/content/journals/10.1146/annurev-pharmtox-051921-093711
/content/journals/10.1146/annurev-pharmtox-051921-093711
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