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Annual Review of Psychology

Volume 69, 2018

Neuro-, Cardio-, and Immunoplasticity: Effects of Early Adversity

Abstract

The relationship between early adversity and outcomes across the lifespan is apparent in a striking range of measures. Evidence suggests that many of these outcomes can be traced to the impacts of early adversity on multiple and integrated biological systems mediated by the brain. In this review, we integrate empirical and theoretical advances in the understanding of relationships among the brain and the functions of the endocrine, autonomic, and immune systems. We emphasize the effects of environmental experiences related to caregiver relationships because it is these experiences, in particular, that shape regulatory and threat response systems in ways that increase vulnerability and may underlie the wide range of poor outcomes associated with early adversity. Thus, we metaphorically extend the concept of plasticity to highlight our goal of a broader consideration of these interconnected mechanisms. We conclude by discussing implications for neurobiologically informed interventions that can potentially ameliorate the broad and costly effects of early adversity.

Keyword(s): autonomic nervous system, early adversity, HPA axis, immune system, neuroplasticity
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2018-01-04
2025-04-21
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Literature Cited

  1. Alkon A, Boyce WT, Tran L, Harley KG, Neuhaus J, Eskenazi B. 2014. Prenatal adversities and Latino children's autonomic nervous system reactivity trajectories from 6 months to 5 years of age. PLOS ONE 9:e86283 [Google Scholar]
  2. Allister L, Lester BM, Carr S, Liu J. 2001. The effects of maternal depression on fetal heart rate response to vibroacoustic stimulation. Dev. Neuropsychol. 20:639–51 [Google Scholar]
  3. Arnsten AF. 2009. Stress signalling pathways that impair prefrontal cortex structure and function. Nat. Rev. Neurosci. 10:410–22 [Google Scholar]
  4. Aron AR, Robbins TW, Poldrack RA. 2004. Inhibition and the right inferior frontal cortex. Trends Cogn. Sci. 8:170–77 [Google Scholar]
  5. Azad MB, Lissitsyn Y, Miller GE, Becker AB, HayGlass KT, Kozyrskyj AL. 2012. Influence of socioeconomic status trajectories on innate immune responsiveness in children. PLOS ONE 7:e38669 [Google Scholar]
  6. Badanes LS, Watamura SE, Hankin BL. 2011. Hypocortisolism as a potential marker of allostatic load in children: associations with family risk and internalizing disorders. Dev. Psychopathol. 23:881–96 [Google Scholar]
  7. Baydar N, Akcinar B. 2015. Ramifications of socioeconomic differences for three year old children and their families in Turkey. Early Child. Res. Q. 33:33–48 [Google Scholar]
  8. Beauchaine TP, Gatzke-Kopp L, Mead HK. 2007. Polyvagal theory and developmental psychopathology: emotion dysregulation and conduct problems from preschool to adolescence. Biol. Psychol. 74:174–84 [Google Scholar]
  9. Beauchaine TP, Thayer JF. 2015. Heart rate variability as a transdiagnostic biomarker of psychopathology. Int. J. Psychophysiol. 98:338–50 [Google Scholar]
  10. Berntson GG, Cacioppo JT, Quigley KS. 1993. Respiratory sinus arrhythmia: autonomic origins, physiological mechanisms, and psychophysiological implications. Psychophysiology 30:183–96 [Google Scholar]
  11. Blair C, Granger DA, Willoughby M, Mills-Koonce R, Cox M. et al. 2011. Salivary cortisol mediates effects of poverty and parenting on executive functions in early childhood. Child Dev 82:1970–84 [Google Scholar]
  12. Blair C, Raver CC. 2012. Child development in the context of adversity: experiential canalization of brain and behavior. Am. Psychol. 67:4309–18 [Google Scholar]
  13. Blair C, Raver CC. 2014. Closing the achievement gap through modification of neurocognitive and neuroendocrine function: results from a cluster randomized controlled trial of an innovative approach to the education of children in kindergarten. PLOS ONE 9:e112393 [Google Scholar]
  14. Blair C, Raver CC. 2015. School readiness and self-regulation: a developmental psychobiological approach. Annu. Rev. Psychol. 66:711–31 [Google Scholar]
  15. Bradbury B, Corak M, Waldfogel J, Washbrook E. 2015. Too Many Children Left Behind: The US Achievement Gap in Comparative Perspective New York: Russell Sage Found. [Google Scholar]
  16. Brito NH, Noble KG. 2014. Socioeconomic status and structural brain development. Front. Neurosci. 8:276 [Google Scholar]
  17. Brooks-Gunn J, Duncan GJ. 1997. The effects of poverty on children. Future Child 7:55–71 [Google Scholar]
  18. Broyles ST, Staiano AE, Drazba KT, Gupta AK, Sothern M, Katzmarzyk PT. 2012. Elevated C-reactive protein in children from risky neighborhoods: evidence for a stress pathway linking neighborhoods and inflammation in children. PLOS ONE 7:e45419 [Google Scholar]
  19. Bruce J, Fisher PA, Pears KC, Levine S. 2009a. Morning cortisol levels in preschool‐aged foster children: differential effects of maltreatment type. Dev. Psychobiol. 51:14–23 [Google Scholar]
  20. Bruce J, Gunnar MR, Pears KC, Fisher PA. 2013. Early adverse care, stress neurobiology, and prevention science: lessons learned. Prev. Sci. 14:247–56 [Google Scholar]
  21. Bruce J, McDermott JM, Fisher PA, Fox NA. 2009b. Using behavioral and electrophysiological measures to assess the effects of a preventive intervention: a preliminary study with preschool-aged foster children. Prev. Sci. 10:129–40 [Google Scholar]
  22. Buckhalt JA. 2011. Insufficient sleep and the socioeconomic status achievement gap. Child Dev. Perspect. 5:59–65 [Google Scholar]
  23. Cacioppo JT, Gardner WL, Berntson GG. 1999. The affect system has parallel and integrative processing components: Form follows function. J. Personal. Soc. Psychol. 76:839–55 [Google Scholar]
  24. Caspi A, Houts RM, Belsky DW, Harrington H, Hogan S. et al. 2016. Childhood forecasting of a small segment of the population with large economic burden. Nat. Hum. Behav. 1:0005 [Google Scholar]
  25. Chapman H, Woltering S, Lamm C, Lewis M. 2010. Hearts and minds: coordination of neurocognitive and cardiovascular regulation in children and adolescents. Biol. Psychol. 84:296–303 [Google Scholar]
  26. Chen E, Cohen S, Miller GE. 2010. How low socioeconomic status affects 2-year hormonal trajectories in children. Psychol. Sci. 21:31–37 [Google Scholar]
  27. Chen E, Hanson MD, Paterson LQ, Griffin MJ, Walker HA, Miller GE. 2006. Socioeconomic status and inflammatory processes in childhood asthma: the role of psychological stress. J. Allergy Clin. Immunol. 117:1014–20 [Google Scholar]
  28. Chen E, Matthews KA. 2003. Development of the cognitive appraisal and understanding of social events (CAUSE) videos. Health Psychol 22:1106–10 [Google Scholar]
  29. Chen E, McLean KC, Miller GE. 2015. Shift-and-persist strategies: associations with socioeconomic status and the regulation of inflammation among adolescents and their parents. Psychosom. Med. 77:371–82 [Google Scholar]
  30. Chen E, Miller GE. 2013. Socioeconomic status and health: mediating and moderating factors. Annu. Rev. Clin. Psychol. 9:723–49 [Google Scholar]
  31. Chen E, Paterson LQ. 2006. Neighborhood, family, and subjective socioeconomic status: How do they relate to adolescent health?. Health Psychol 25:704–14 [Google Scholar]
  32. Cicchetti D, Rogosch FA. 2001. The impact of child maltreatment and psychopathology on neuroendocrine functioning. Dev. Psychopathol. 13:783–804 [Google Scholar]
  33. Cicchetti D, Rogosch FA. 2009. Adaptive coping under conditions of extreme stress: multilevel influences on the determinants of resilience in maltreated children. New Dir. Child Adolesc. Dev. 2009:12447–59 [Google Scholar]
  34. Conradt E, Beauchaine T, Abar B, Lagasse L, Shankaran S. et al. 2016. Early caregiving stress exposure moderates the relation between respiratory sinus arrhythmia reactivity at 1 month and biobehavioral outcomes at age 3. Psychophysiology 53:83–96 [Google Scholar]
  35. Conradt E, Measelle J, Ablow JC. 2013. Poverty, problem behavior, and promise: differential susceptibility among infants reared in poverty. Psychol. Sci. 24:235–42 [Google Scholar]
  36. D'Angiulli A, Herdman A, Stapells D, Hertzman C. 2008. Children's event-related potentials of auditory selective attention vary with their socioeconomic status. Neuropsychology 22:293–300 [Google Scholar]
  37. Dantzer R, O'Connor JC, Freund GG, Johnson RW, Kelley KW. 2008. From inflammation to sickness and depression: when the immune system subjugates the brain. Nat. Rev. Neurosci. 9:46–56 [Google Scholar]
  38. Del Giudice M, Ellis BJ, Shirtcliff EA. 2011. The adaptive calibration model of stress responsivity. Neurosci. Biobehav. Rev. 35:1562–92 [Google Scholar]
  39. Dillon DG, Holmes AJ, Birk JL, Brooks N, Lyons-Ruth K, Pizzagalli DA. 2009. Childhood adversity is associated with left basal ganglia dysfunction during reward anticipation in adulthood. Biol. Psychiatry 66:206–13 [Google Scholar]
  40. DiPietro JA, Hodgson DM, Costigan KA, Hilton SC, Johnson TR. 1996. Fetal neurobehavioral development. Child Dev 67:52553–67 [Google Scholar]
  41. Dozier M, Manni M, Gordon MK, Peloso E, Gunnar MR. et al. 2006. Foster children's diurnal production of cortisol: an exploratory study. Child Maltreat 11:189–97 [Google Scholar]
  42. Duc NHC. 2016. Developmental risk factors in Vietnamese preschool‐age children: cross‐sectional survey. Pediatr. Int. 58:114–21 [Google Scholar]
  43. Duncan G, Brooks-Gunn J, Klebanov P. 1994. Economic deprivation and early childhood development. Child Dev 65:296–318 [Google Scholar]
  44. Eisenberger NI, Berkman ET, Inagaki TK, Rameson LT, Mashal NM, Irwin MR. 2010. Inflammation-induced anhedonia: Endotoxin reduces ventral striatum responses to reward. Biol. Psychiatry 68:748–54 [Google Scholar]
  45. Ellis B, Boyce W. 2008. Biological sensitivity to context. Psychol. Sci. 17:183–87 [Google Scholar]
  46. El-Sheikh M, Hinnant JB, Erath S. 2011. Developmental trajectories of delinquency symptoms in childhood: the role of marital conflict and autonomic nervous system activity. J. Abnorm. Psychol. 120:16–32 [Google Scholar]
  47. El-Sheikh M, Kouros CD, Erath S, Cummings EM, Keller P, Staton L. 2009. Marital conflict and children's externalizing behavior: pathways involving interactions between parasympathetic and sympathetic nervous system activity. Monogr. Soc. Res. Child Dev. 74:vii [Google Scholar]
  48. Evans G. 2004. The environment of childhood poverty. Am. Psychol. 59:77–92 [Google Scholar]
  49. Evans GW, English K. 2002. The environment of poverty: multiple stressor exposure, psychophysiological stress, and socioemotional adjustment. Child Dev 73:1238–48 [Google Scholar]
  50. Evans GW, Gonnella C, Marcynyszyn LA, Gentile L, Salpekar N. 2005. The role of chaos in poverty and children's socioemotional adjustment. Psychol. Sci. 16:560–65 [Google Scholar]
  51. Evans GW, Schamberg MA. 2009. Childhood poverty, chronic stress, and adult working memory. PNAS 106:6545–49 [Google Scholar]
  52. Farah M, Betancourt L, Shera D, Savage J, Giannetta J. et al. 2008. Environmental stimulation, parental nurturance and cognitive development in humans. Dev. Sci. 11:793–801 [Google Scholar]
  53. Farah M, Shera D, Savage J, Betancourt L, Giannetta J. et al. 2006. Childhood poverty: specific associations with neurocognitive development. Brain Res 1110:166–74 [Google Scholar]
  54. Fernald LC, Kariger P, Hidrobo M, Gertler PJ. 2012. Socioeconomic gradients in child development in very young children: evidence from India, Indonesia, Peru, and Senegal. PNAS 109:Suppl. 217273–80 [Google Scholar]
  55. Fernald LC, Weber A, Galasso E, Ratsifandrihamanana L. 2011. Socioeconomic gradients and child development in a very low income population: evidence from Madagascar. Dev. Sci. 14:4832–47 [Google Scholar]
  56. Field T, Pickens J, Fox NA, Nawrocki T, Gonzalez J. 1995. Vagal tone in infants of depressed mothers. Dev. Psychopathol. 7:227–31 [Google Scholar]
  57. Fisher PA, Beauchamp KG, Roos LE, Noll LK, Flannery J, Delker BC. 2016. The neurobiology of intervention and prevention in early adversity. Annu. Rev. Clin. Psychol. 12:331–57 [Google Scholar]
  58. Fisher PA, Stoolmiller M. 2008. Intervention effects on foster parent stress: associations with child cortisol levels. Dev. Psychopathol. 20:1003–21 [Google Scholar]
  59. Fisher PA, Stoolmiller M, Gunnar MR, Burraston BO. 2007. Effects of a therapeutic intervention for foster preschoolers on diurnal cortisol activity. Psychoneuroendocrinology 32:892–905 [Google Scholar]
  60. Gee DG, Gabard-Durnam LJ, Flannery J, Goff B, Humphreys KL. et al. 2013. Early developmental emergence of human amygdala–prefrontal connectivity after maternal deprivation. PNAS 110:15638–43 [Google Scholar]
  61. Gianaros P, Manuck SB, Sheu L, Votruba-Drzal E, Craig A, Hariri A. 2011. Parental education predicts corticostriatal functionality in adulthood. Cereb. Cortex 21:896–910 [Google Scholar]
  62. Gianaros PJ, Horenstein JA, Hariri AR, Sheu LK, Manuck SB. et al. 2008. Potential neural embedding of parental social standing. Soc. Cogn. Affect. Neurosci. 3:291–96 [Google Scholar]
  63. Gianaros PJ, Marsland AL, Sheu LK, Erickson KI, Verstynen TD. 2012. Inflammatory pathways link socioeconomic inequalities to white matter architecture. Cereb. Cortex 23:92058–71 [Google Scholar]
  64. Goodman E, Slap GB, Huang B. 2003. The public health impact of socioeconomic status on adolescent depression and obesity. Am. J. Public Health 93:1844–50 [Google Scholar]
  65. Graziano P, Derefinko K. 2013. Cardiac vagal control and children's adaptive functioning: a meta-analysis. Biol. Psychol. 94:22–37 [Google Scholar]
  66. Gunnar M, Quevedo K. 2007. The neurobiology of stress and development. Annu. Rev. Psychol. 58:145–73 [Google Scholar]
  67. Gunnar MR, Brodersen L, Nachmias M, Buss K, Rigatuso J. 1996. Stress reactivity and attachment security. Dev. Psychobiol. 29:191–204 [Google Scholar]
  68. Gunnar MR, Morison SJ, Chisholm K, Schuder M. 2001. Salivary cortisol levels in children adopted from Romanian orphanages. Dev. Psychopathol. 13:611–28 [Google Scholar]
  69. Gunnar MR, Vazquez DM. 2001. Low cortisol and a flattening of expected daytime rhythm: potential indices of risk in human development. Dev. Psychopathol. 13:515–38 [Google Scholar]
  70. Haber SN, Knutson B. 2010. The reward circuit: linking primate anatomy and human imaging. Neuropsychopharmacology 35:4–26 [Google Scholar]
  71. Hackman D, Farah M, Meaney M. 2010. Socioeconomic status and the brain: mechanistic insights from human and animal research. Nat. Rev. Neurosci. 11:651–59 [Google Scholar]
  72. Hamadani JD, Tofail F, Huda SN, Alam DS, Ridout DA. et al. 2014. Cognitive deficit and poverty in the first 5 years of childhood in Bangladesh. Pediatrics 134:4e1001–8 [Google Scholar]
  73. Hampton Wray A, Stevens C, Pakulak E, Isbell E, Bell T, Neville H. 2017. Development of selective attention in preschool-age children from lower socioeconomic status backgrounds. Dev. Cogn. Neurosci. 26:101–11 [Google Scholar]
  74. Hansen AL, Johnsen BH, Thayer JF. 2003. Vagal influence on working memory and attention. Int. J. Psychophysiol. 48:263–74 [Google Scholar]
  75. Hanson JL, Chandra A, Wolfe BL, Pollak SD. 2011. Association between income and the hippocampus. PLOS ONE 6:e18712 [Google Scholar]
  76. Harrison NA, Brydon L, Walker C, Gray MA, Steptoe A, Critchley HD. 2009. Inflammation causes mood changes through alterations in subgenual cingulate activity and mesolimbic connectivity. Biol. Psychiatry 66:407–14 [Google Scholar]
  77. Heckman JJ. 2006. Skill formation and the economics of investing in disadvantaged children. Science 312:1900–2 [Google Scholar]
  78. Hertzman C, Boyce T. 2010. How experience gets under the skin to create gradients in developmental health. Annu. Rev. Public Health 31:329–47 [Google Scholar]
  79. Hoffmann R, Hu Y, De Gelder R, Menvielle G, Bopp M, Mackenbach JP. 2016. The impact of increasing income inequalities on educational inequalities in mortality: an analysis of six European countries. Int. J. Equity Health 15:103 [Google Scholar]
  80. Holzer HJ, Whitmore Schanzenbach D, Duncan GJ, Ludwig J. 2008. The economic costs of childhood poverty in the United States. J. Child. Poverty 14:41–61 [Google Scholar]
  81. Irwin MR, Cole SW. 2011. Reciprocal regulation of the neural and innate immune systems. Nat. Rev. Immunol. 11:625–32 [Google Scholar]
  82. Irwin MR, Olmstead R, Carroll JE. 2016. Sleep disturbance, sleep duration, and inflammation: a systematic review and meta-analysis of cohort studies and experimental sleep deprivation. Biol. Psychiatry 80:40–52 [Google Scholar]
  83. Jednoróg K, Altarelli I, Monzalvo K, Fluss J, Dubois J. et al. 2012. The influence of socioeconomic status on children's brain structure. PLOS ONE 7:e42486 [Google Scholar]
  84. Joëls M, Baram TZ. 2009. The neuro-symphony of stress. Nat. Rev. Neurosci. 10:459–66 [Google Scholar]
  85. Kiecolt-Glaser JK. 2010. Stress, food, and inflammation: psychoneuroimmunology and nutrition at the cutting edge. Psychosom. Med. 72:365–69 [Google Scholar]
  86. Kim P, Evans GW, Angstadt M, Ho SS, Sripada CS. et al. 2013. Effects of childhood poverty and chronic stress on emotion regulatory brain function in adulthood. PNAS 110:18442–47 [Google Scholar]
  87. Kimhy D, Crowley O, McKinley P, Burg M, Lachman M. et al. 2013. The association of cardiac vagal control and executive functioning: findings from the MIDUS study. J. Psychiatric Res. 47:628–35 [Google Scholar]
  88. Kishiyama MM, Boyce WT, Jimenez AM, Perry LM, Knight RT. 2009. Socioeconomic disparities affect prefrontal function in children. J. Cogn. Neurosci 21:61106–15 [Google Scholar]
  89. Kittleson MM, Meoni LA, Wang N-Y, Chu AY, Ford DE, Klag MJ. 2006. Association of childhood socioeconomic status with subsequent coronary heart disease in physicians. Arch. Intern. Med. 166:2356–61 [Google Scholar]
  90. Koss KJ, Hostinar CE, Donzella B, Gunnar MR. 2014. Social deprivation and the HPA axis in early development. Psychoneuroendocrinology 50:1–13 [Google Scholar]
  91. Lipina S, Martelli M, Vuelta B, Colombo J. 2005. Performance on the A-not-B task of Argentinian infants from unsatisfied and satisfied basic needs homes. Interam. J. Psychol. 39:49–60 [Google Scholar]
  92. Lipina SJ, Posner MI. 2012. The impact of poverty on the development of brain networks. Front. Hum. Neurosci. 6:238 [Google Scholar]
  93. Liston C, McEwen BS, Casey BJ. 2009. Psychosocial stress reversibly disrupts prefrontal processing and attentional control. PNAS 106:912–17 [Google Scholar]
  94. Loman MM, Gunnar MR. 2010. Early experience and the development of stress reactivity and regulation in children. Neurosci. Biobehav. Rev. 34:867–76 [Google Scholar]
  95. Luby J, Belden A, Botteron K, Marrus N, Harms MP. et al. 2013. The effects of poverty on childhood brain development: the mediating effect of caregiving and stressful life events. JAMA Pediatr 167:1135–42 [Google Scholar]
  96. Lupien SJ, King S, Meaney MJ, McEwen BS. 2001. Can poverty get under your skin? Basal cortisol levels and cognitive function in children from low and high socioeconomic status. Dev. Psychopathol. 13:653–76 [Google Scholar]
  97. Lupien SJ, McEwen BS, Gunnar MR, Heim C. 2009. Effects of stress throughout the lifespan on the brain, behaviour and cognition. Nat. Rev. Neurosci. 10:434–45 [Google Scholar]
  98. Maier SF, Amal J, Baratta MV, Paul E, Watkins LR. 2006. Behavioral control, the medial prefrontal cortex, and resilience. Dialogues Clin. Neurosci. 8:4397–406 [Google Scholar]
  99. Marcovitch S, Leigh J, Calkins SD, Leerks EM, O'Brien M, Blankson AN. 2010. Moderate vagal withdrawal in 3.5-year-old children is associated with optimal performance on executive function tasks. Dev. Psychobiol. 52:603–8 [Google Scholar]
  100. Marmot M. 2015. The Health Gap: The Challenge of an Unequal World London: Bloomsbury [Google Scholar]
  101. Marsland AL, Gianaros PJ, Abramowitch SM, Manuck SB, Hariri AR. 2008. Interleukin-6 covaries inversely with hippocampal grey matter volume in middle-aged adults. Biol. Psychiatry 64:484–90 [Google Scholar]
  102. McDermott JM, Westerlund A, Zeanah CH, Nelson CA, Fox NA. 2012. Early adversity and neural correlates of executive function: implications for academic adjustment. Dev. Cogn. Neurosci. 2:S59–66 [Google Scholar]
  103. McEwen BS, Gianaros PJ. 2010. Central role of the brain in stress and adaptation: links to socioeconomic status, health, and disease. Ann. N. Y. Acad. Sci. 1186:190–222 [Google Scholar]
  104. McEwen BS, Stellar E. 1993. Stress and the individual: mechanisms leading to disease. Arch. Intern. Med. 153:2093–101 [Google Scholar]
  105. McLaughlin KA, Sheridan MA, Tibu F, Fox NA, Zeanah CH, Nelson CA. 2015. Causal effects of the early caregiving environment on development of stress response systems in children. PNAS 112:5637–42 [Google Scholar]
  106. McLoyd V. 1998. Socioeconomic disadvantage and child development. Am. Psychol. 53:185–204 [Google Scholar]
  107. Merikangas KR, He J-P, Burstein M, Swanson SA, Avenevoli S. et al. 2010. Lifetime prevalence of mental disorders in US adolescents: results from the National Comorbidity Survey Replication-Adolescent Supplement (NCS-A). J. Am. Acad. Child Adolesc. Psychiatry 49:980–89 [Google Scholar]
  108. Miller AH, Maletic V, Raison CL. 2009. Inflammation and its discontents: the role of cytokines in the pathophysiology of major depression. Biol. Psychiatry 65:732–41 [Google Scholar]
  109. Miller GE, Brody GH, Yu T, Chen E. 2014. A family-oriented psychosocial intervention reduces inflammation in low-SES African American youth. PNAS 111:11287–92 [Google Scholar]
  110. Miller GE, Chen E. 2010. Harsh family climate in early life presages the emergence of a proinflammatory phenotype in adolescence. Psychol. Sci. 21:6848–56 [Google Scholar]
  111. Miller GE, Chen E, Fok AK, Walker H, Lim A. et al. 2009. Low early-life social class leaves a biological residue manifested by decreased glucocorticoid and increased proinflammatory signaling. PNAS 106:14716–21 [Google Scholar]
  112. Miller GE, Chen E, Parker KJ. 2011a. Psychological stress in childhood and susceptibility to the chronic diseases of aging: moving toward a model of behavioral and biological mechanisms. Psychol. Bull. 137:959–97 [Google Scholar]
  113. Miller GE, Chen E, Zhou ES. 2007. If it goes up, must it come down? Chronic stress and the hypothalamic-pituitary-adrenocortical axis in humans. Psychol. Bull. 133:25–45 [Google Scholar]
  114. Miller GE, Lachman ME, Chen E, Gruenewald TL, Karlamangla AS, Seeman TE. 2011b. Pathways to resilience: maternal nurturance as a buffer against the effects of childhood poverty on metabolic syndrome at midlife. Psychol. Sci. 22:1591–99 [Google Scholar]
  115. Moore GA. 2010. Parent conflict predicts infants' vagal regulation in social interaction. Dev. Psychopathol. 22:23–33 [Google Scholar]
  116. Mueller EM, Stemmler G, Wacker J. 2010. Single-trial electroencephalogram predicts cardiac acceleration: a time-lagged P-correlation approach for studying neurovisceral connectivity. Neuroscience 166:491–500 [Google Scholar]
  117. Neville H, Pakulak E, Stevens C. 2015. Family-based training to improve cognitive outcomes for children from lower socioeconomic status backgrounds: emerging themes and challenges. Curr. Opin. Behav. Sci. 4:166–70 [Google Scholar]
  118. Neville HJ, Stevens C, Pakulak E, Bell TA, Fanning J. et al. 2013. Family-based training program improves brain function, cognition, and behavior in lower socioeconomic status preschoolers. PNAS 110:912138–43 [Google Scholar]
  119. Noble K, McCandliss B, Farah M. 2007. Socioeconomic gradients predict individual differences in neurocognitive abilities. Dev. Sci. 10:464–80 [Google Scholar]
  120. Noble KG, Houston SM, Brito NH, Bartsch H, Kan E. et al. 2015. Family income, parental education and brain structure in children and adolescents. Nat. Neurosci. 18:773–78 [Google Scholar]
  121. Noble KG, Houston SM, Kan E, Sowell ER. 2012. Neural correlates of socioeconomic status in the developing human brain. Dev. Sci. 15:516–27 [Google Scholar]
  122. Noble KG, Norman MF, Farah MJ. 2005. Neurocognitive correlates of socioeconomic status in kindergarten children. Dev. Sci. 8:74–87 [Google Scholar]
  123. Nusslock R, Miller GE. 2016. Early-life adversity and physical and emotional health across the lifespan: a neuroimmune network hypothesis. Biol. Psychiatry 80:23–32 [Google Scholar]
  124. Obradovic J, Bush NR, Stamperdahl J, Adler NE, Boyce WT. 2010. Biological sensitivity to context: the interactive effects of stress reactivity and family adversity on socioemotional behavior and school readiness. Child Dev 81:270–89 [Google Scholar]
  125. Oosterman M, De Schipper JC Fisher P, Dozier M, Schuengel C. 2010. Autonomic reactivity in relation to attachment and early adversity among foster children. Dev. Psychopathol. 22:109–18 [Google Scholar]
  126. Pace TW, Hu F, Miller AH. 2007. Cytokine-effects on glucocorticoid receptor function: relevance to glucocorticoid resistance and the pathophysiology and treatment of major depression. Brain Behav. Immun. 21:9–19 [Google Scholar]
  127. Park G, Thayer JF. 2014. From the heart to the mind: Cardiac vagal tone modulates top-down and bottom-up visual perception and attention to emotional stimuli. Front. Psychol. 5:278 [Google Scholar]
  128. Phelps EA, LeDoux JE. 2005. Contributions of the amygdala to emotion processing: from animal models to human behavior. Neuron 48:175–87 [Google Scholar]
  129. Pollak SD, Vardi S, Putzer Bechner AM, Curtin JJ. 2005. Physically abused children's regulation of attention in response to hostility. Child Dev 76:968–77 [Google Scholar]
  130. Porges SW. 1996. Physiological regulation in high-risk infants: a model for assessment and potential intervention. Dev. Psychopathol. 8:43–58 [Google Scholar]
  131. Porges SW. 2007. The polyvagal perspective. Biol. Psychol. 74:116–43 [Google Scholar]
  132. Porter CL. 2003. Coregulation in mother-infant dyads: links to infants' cardiac vagal tone. Psychol. Rep. 92:307–19 [Google Scholar]
  133. Porter CL, Wouden-Miller M, Silva SS, Porter AE. 2003. Marital harmony and conflict: links to infants' emotional regulation and cardiac vagal tone. Infancy 4:297–307 [Google Scholar]
  134. Powell ND, Mays JW, Bailey MT, Hanke ML, Sheridan JF. 2011. Immunogenic dendritic cells primed by social defeat enhance adaptive immunity to influenza A virus. Brain Behav. Immun. 25:46–52 [Google Scholar]
  135. Propper CB, Holochwost SJ. 2013. The influence of proximal risk on the early development of the autonomic nervous system. Dev. Rev. 33:151–67 [Google Scholar]
  136. Raizada RDS, Richards TL, Meltzoff A, Kuhl PK. 2008. Socioeconomic status predicts hemispheric specialisation of the left inferior frontal gyrus in young children. NeuroImage 40:1392–401 [Google Scholar]
  137. Rao H, Betancourt L, Giannetta JM, Brodsky NL, Korczykowski M. et al. 2010. Early prenatal care is important for hippocampal maturation: evidence from brain morphology in humans. NeuroImage 49:1144–50 [Google Scholar]
  138. Raver CC, Blair C, Willoughby M. 2013. Poverty as a predictor of 4-year-olds' executive function: new perspectives on models of differential susceptibility. Dev. Psychol. 49:292–304 [Google Scholar]
  139. Rubio-Codina M, Attanasio O, Meghir C, Varela N, Grantham-McGregor S. 2015. The socioeconomic gradient of child development: cross-sectional evidence from children 6–42 months in Bogota. J. H. Resour. 50:2464–83 [Google Scholar]
  140. Saez E, Zucman G. 2016. Wealth inequality in the United States since 1913: evidence from capitalized income tax data. Q. J. Econ. 131:519–78 [Google Scholar]
  141. Sapolsky RM. 2004. Social status and health in humans and other animals. Annu. Rev. Anthropol. 33:393–418 [Google Scholar]
  142. Sarsour K, Sheridan M, Jutte D, Nuru-Jeter A, Hinshaw S, Boyce W. 2011. Family socioeconomic status and child executive functions: the roles of language, home environment, and single parenthood. J. Int. Neuropsychol. Soc. 17:120–32 [Google Scholar]
  143. Schady N, Behrman J, Araujo MC, Azuero R, Bernal R. et al. 2015. Wealth gradients in early childhood cognitive development in five Latin American countries. J. Hum. Resour. 50:2446–63 [Google Scholar]
  144. Schickedanz A, Dreyer BP, Halfon N. 2015. Childhood poverty: understanding and preventing the adverse impacts of a most-prevalent risk to pediatric health and well-being. Pediatr. Clin. North Am. 62:1111–35 [Google Scholar]
  145. Schuetze P, Eiden RD, Colder CR, Gray TR, Huestis MA. 2011. Physiological regulation in cigarette exposed infants: an examination of potential moderators. Neurotoxicol. Teratol. 33:567–74 [Google Scholar]
  146. Sheridan MA, Sarsour K, Jutte D, D'Esposito M, Boyce WT. 2012. The impact of social disparity on prefrontal function in childhood. PLOS ONE 7:e35744 [Google Scholar]
  147. Shonkoff JP. 2012. Leveraging the biology of adversity to address the roots of disparities in health and development. PNAS 109:17302–7 [Google Scholar]
  148. Shonkoff JP, Bales SN. 2011. Science does not speak for itself: translating child development research for the public and its policymakers. Child Dev 82:17–32 [Google Scholar]
  149. Shonkoff JP, Garner AS, Siegel BS, Dobbins MI, Earls MF. et al. 2012. The lifelong effects of early childhood adversity and toxic stress. Pediatrics 129:e232–46 [Google Scholar]
  150. Shook N, Pena P, Fazio RH, Sollers JJ III, Thayer JF. 2007. Friend or foe: heart rate variability and the negativity bias in learning about novel objects. Psychophysiology 44:S39 [Google Scholar]
  151. Skowron EA, Cipriano‐Essel E, Gatzke‐Kopp LM, Teti DM, Ammerman RT. 2014. Early adversity, RSA, and inhibitory control: evidence of children's neurobiological sensitivity to social context. Dev. Psychobiol. 56:964–78 [Google Scholar]
  152. Sloan RP, Huang M-H, Sidney S, Liu K, Williams OD, Seeman T. 2005. Socioeconomic status and health: Is parasympathetic nervous system activity an intervening mechanism. Int. J. Epidemiol. 34:309–15 [Google Scholar]
  153. Slopen N, McLaughlin KA, Shonkoff JP. 2014. Interventions to improve cortisol regulation in children: a systematic review. Pediatrics 133:2312–26 [Google Scholar]
  154. Stevens C, Lauinger B, Neville H. 2009. Differences in the neural mechanisms of selective attention in children from different socioeconomic backgrounds: an event-related brain potential study. Dev. Sci. 12:634–46 [Google Scholar]
  155. Stevens C, Neville H. 2006. Neuroplasticity as a double-edged sword: deaf enhancements and dyslexic deficits in motion processing. J. Cogn. Neurosci. 18:701–4 [Google Scholar]
  156. Thayer JF, Åhs F, Fredrikson M, Sollers JJ, Wager TD. 2012. A meta-analysis of heart rate variability and neuroimaging studies: implications for heart rate variability as a marker of stress and health. Neurosci. Biobehav. Rev. 36:747–56 [Google Scholar]
  157. Thayer JF, Brosschot JF. 2005. Psychosomatics and psychopathology: looking up and down from the brain. Psychoneuroendocrinology 30:1050–58 [Google Scholar]
  158. Thayer JF, Friedman BH. 2002. Stop that! Inhibition, sensitization, and their neurovisceral concomitants. Scand. J. Psychol. 43:123–30 [Google Scholar]
  159. Thayer JF, Lane RD. 2007. The role of vagal function in the risk for cardiovascular disease and mortality. Biol. Psychol. 74:224–42 [Google Scholar]
  160. Thayer JF, Lane RD. 2009. Claude Bernard and the heart–brain connection: further elaboration of a model of neurovisceral integration. Neurosci. Biobehav. Rev. 33:81–88 [Google Scholar]
  161. Thayer JF, Sternberg E. 2006. Beyond heart rate variability. Ann. N. Y. Acad. Sci. 1088:361–72 [Google Scholar]
  162. Tottenham N, Hare T, Millner A, Gilhooly T, Zevin J, Casey B. 2011. Elevated amygdala response to faces following early deprivation. Dev. Sci. 14:190–204 [Google Scholar]
  163. Tottenham N, Hare TA, Quinn BT, McCarry TW, Nurse M. et al. 2010. Prolonged institutional rearing is associated with atypically large amygdala volume and difficulties in emotion regulation. Dev. Sci. 13:46–61 [Google Scholar]
  164. Tottenham N, Sheridan MA. 2010. A review of adversity, the amygdala and the hippocampus: a consideration of developmental timing. Front. Hum. Neurosci. 3:68 [Google Scholar]
  165. Tracy M, Zimmerman FJ, Galea S, McCauley E, Vander Stoep A. 2008. What explains the relation between family poverty and childhood depressive symptoms. J. Psychiatric Res. 42:1163–75 [Google Scholar]
  166. Ursache A, Blair C, Stifter C, Voegtline K. 2013. Emotional reactivity and regulation in infancy interact to predict executive functioning in early childhood. Dev. Psychol. 49:127–37 [Google Scholar]
  167. Ursache A, Noble KG. 2016. Neurocognitive development in socioeconomic context: multiple mechanisms and implications for measuring socioeconomic status. Psychophysiology 53:71–82 [Google Scholar]
  168. Ursache A, Noble KG, Blair C. 2015. Socioeconomic status, subjective social status, and perceived stress: associations with stress physiology and executive functioning. Behav. Med. 41:145–54 [Google Scholar]
  169. Wilkinson RG, Pickett K. 2009. The Spirit Level: Why More Equal Societies Almost Always Do Better London: Allen Lane [Google Scholar]
  170. Wright RJ, Visness CM, Calatroni A, Grayson MH, Gold DR. et al. 2010. Prenatal maternal stress and cord blood innate and adaptive cytokine responses in an inner-city cohort. Am. J. Respir. Crit. Care Med. 182:25–33 [Google Scholar]
  171. Yanbaeva DG, Dentener MA, Creutzberg EC, Wesseling G, Wouters EF. 2007. Systemic effects of smoking. Chest J 131:1557–66 [Google Scholar]
  172. Ziol-Guest KM, Duncan GJ, Kalil A, Boyce WT. 2012. Early childhood poverty, immune-mediated disease processes, and adult productivity. PNAS 109:17289–93 [Google Scholar]
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