1932

Abstract

This article provides an overview of the fields of psychosocial and integrative oncology, highlighting common psychological reactions to being diagnosed with and treated for cancer, including distress, anxiety, depression, fear of cancer recurrence and caregiver burden, as well as symptoms of fatigue, pain, and sleep disturbance. Patterns of symptomatology across the disease continuum are also discussed. Interventions targeted at treating these symptoms are reviewed, including acceptance-based and mindfulness therapies, mind-body therapies, and meaning-based approaches designed for people with advanced stages of disease, including psychedelic therapy. Common methodological issues and shortcomings of the evidence base are summarized with design recommendations, and a discussion of trends in future research including pragmatic research design, digital health interventions, and implementation science completes the article.

Loading

Article metrics loading...

/content/journals/10.1146/annurev-psych-032620-031757
2023-01-18
2024-07-23
Loading full text...

Full text loading...

/deliver/fulltext/psych/74/1/annurev-psych-032620-031757.html?itemId=/content/journals/10.1146/annurev-psych-032620-031757&mimeType=html&fmt=ahah

Literature Cited

  1. Aapro M, Scotte F, Bouillet T, Currow D, Vigano A. 2017. A practical approach to fatigue management in colorectal cancer. Clin. Colorectal Cancer 16:4275–85
    [Google Scholar]
  2. Aguilar BA. 2017. The efficacy of art therapy in pediatric oncology patients: an integrative literature review. J. Pediatr. Nurs. 36:173–78
    [Google Scholar]
  3. Almeida SN, Elliott R, Silva ER, Sales CMD. 2019. Fear of cancer recurrence: a qualitative systematic review and meta-synthesis of patients’ experiences. Clin. Psychol. Rev. 68:13–24
    [Google Scholar]
  4. Antoni MH, Moreno PI, Penedo FJ. 2023. Stress management interventions to facilitate psychological and physiological adaptation and optimal health outcomes in cancer patients and survivors. Annu. Rev. Psychol. 74:42355
    [Google Scholar]
  5. Arch JJ, Mitchell JL. 2016. An Acceptance and Commitment Therapy (ACT) group intervention for cancer survivors experiencing anxiety at re-entry. Psycho-Oncology 25:5610–15
    [Google Scholar]
  6. Baydoun M, McLennan AIG, Carlson LE, iCARE Study Team. 2022. People with cancer experience significantly worse psychosocial and financial consequences of COVID-19 compared to healthy individuals and other chronic disease populations: findings from the international COVID-19 Awareness and Response Evaluation (iCARE) study. Cancers Submitted
    [Google Scholar]
  7. Baydoun M, Oberoi D, Flynn M, Moran C, McLennan A et al. 2020. Effects of yoga-based interventions on cancer-associated cognitive decline: a systematic review. Curr. Oncol. Rep. 22:10100
    [Google Scholar]
  8. Ben-Arye E, Paller C, Lopez AM, White S, Pendleton E et al. 2021. The Society for Integrative Oncology Practice Recommendations for online consultation and treatment during the COVID-19 pandemic. Support Care Cancer 29:6155–65
    [Google Scholar]
  9. Biggs A, Brough P, Drummond S 2017. Lazarus and Folkman's psychological stress and coping theory. The Handbook of Stress and Health: A Guide to Research and Practice CL Cooper, JC Quick 351–64 Hoboken, NJ: Wiley
    [Google Scholar]
  10. Bradt J, Dileo C, Magill L, Teague A. 2016. Music interventions for improving psychological and physical outcomes in cancer patients. Cochrane Database Syst. Rev. 8:CD006911
    [Google Scholar]
  11. Brandenbarg D, Maass SWMC, Geerse OP, Stegmann ME, Handberg C et al. 2019. A systematic review on the prevalence of symptoms of depression, anxiety and distress in long-term cancer survivors: implications for primary care. Eur. J. Cancer Care 28:3 https://doi.org/10.1111/ecc.13086
    [Crossref] [Google Scholar]
  12. Breitbart W. 2002. Spirituality and meaning in supportive care: spirituality- and meaning-centered group psychotherapy interventions in advanced cancer. Support. Care Cancer 10:4272–80
    [Google Scholar]
  13. Breitbart W, Butow P, Jacobsen P, Lam W, Lazenby M, Loscalzo M, eds. 2021. Psycho-Oncology Oxford, UK: Oxford Univ. Press
    [Google Scholar]
  14. Breitbart W, Pessin H, Rosenfeld B, Applebaum AJ, Lichtenthal WG et al. 2018. Individual meaning-centered psychotherapy for the treatment of psychological and existential distress: a randomized controlled trial in patients with advanced cancer. Cancer 124:153231–39
    [Google Scholar]
  15. Breitbart W, Rosenfeld B, Pessin H, Applebaum A, Kulikowski J, Lichtenthal WG. 2015. Meaning-centered group psychotherapy: an effective intervention for improving psychological well-being in patients with advanced cancer. J. Clin. Oncol. 33:7749–54
    [Google Scholar]
  16. Büttner-Teleagă A, Kim YT, Osel T, Richter K. 2021. Sleep disorders in cancer—a systematic review. Int. J. Environ. Res. Public Health 18:2111696
    [Google Scholar]
  17. Carlson LE. 2018. Uptake of mindfulness-based interventions: a phenomenon of wealthy white western women?. Clin. Psychol. Sci. Pract. 25:3e12258
    [Google Scholar]
  18. Carlson LE 2021. Mindfulness-based interventions. Psycho-Oncology W Breitbart, P Butow, P Jacobsen, W Lam, M Lazenby, M Loscalzo 429–37 Oxford, UK: Oxford Univ. Press
    [Google Scholar]
  19. Carlson LE, Beattie TL, Giese-Davis J, Faris P, Tamagawa R et al. 2015. Mindfulness-based cancer recovery and supportive-expressive therapy maintain telomere length relative to controls in distressed breast cancer survivors. Cancer 121:3476–84
    [Google Scholar]
  20. Carlson LE, Tamagawa R, Stephen J, Doll R, Faris P et al. 2014. Tailoring mind-body therapies to individual needs: patients’ program preference and psychological traits as moderators of the effects of mindfulness-based cancer recovery and supportive-expressive therapy in distressed breast cancer survivors. JNCI Monogr. 2014:50308–14
    [Google Scholar]
  21. Carlson LE, Toivonen K, Flynn M, Deleemans J, Piedalue K-A et al. 2018. The role of hypnosis in cancer care. Curr. Oncol. Rep. 20:1293
    [Google Scholar]
  22. Carlson LE, Waller A, Groff SL, Giese-Davis J, Bultz BD. 2013. What goes up does not always come down: patterns of distress, physical and psychosocial morbidity in people with cancer over a one year period. Psycho-Oncology 22:1168–76
    [Google Scholar]
  23. Carlson LE, Zelinski E, Toivonen K, Flynn M, Qureshi M et al. 2017. Mind-body therapies in cancer: What is the latest evidence?. Curr. Oncol. Rep. 19:67
    [Google Scholar]
  24. Caruso R, Nanni MG, Riba MB, Sabato S, Grassi L. 2017. The burden of psychosocial morbidity related to cancer: patient and family issues. Int. Rev. Psychiatry 29:5389–402
    [Google Scholar]
  25. Chen P-Y, Liu Y-M, Chen M-L. 2017. The effect of hypnosis on anxiety in patients with cancer: a meta-analysis. Worldviews Evidence-Based Nurs. 14:3223–36
    [Google Scholar]
  26. Chochinov HM. 2002. Dignity-conserving care—a new model for palliative care: helping the patient feel valued. JAMA 287:172253–60
    [Google Scholar]
  27. Chochinov HM. 2007. Dignity and the essence of medicine: the A, B, C, and D of dignity conserving care. BMJ 335:7612184–87
    [Google Scholar]
  28. Chochinov HM, Kristjanson LJ, Breitbart W, McClement S, Hack TF et al. 2011. Effect of dignity therapy on distress and end-of-life experience in terminally ill patients: a randomised controlled trial. Lancet Oncol. 12:8753–62
    [Google Scholar]
  29. Cillessen L, Johannsen M, Speckens AEM, Zachariae R. 2019. Mindfulness-based interventions for psychological and physical health outcomes in cancer patients and survivors: a systematic review and meta-analysis of randomized controlled trials. Psycho-Oncology 28:122257–69
    [Google Scholar]
  30. Coumoundouros C, Ould Brahim L, Lambert SD, McCusker J 2019. The direct and indirect financial costs of informal cancer care: a scoping review. Health Soc. Care Community 27:5e622–36
    [Google Scholar]
  31. Cramer H, Lauche R, Paul A, Langhorst J, Kümmel S, Dobos GJ. 2015. Hypnosis in breast cancer care: a systematic review of randomized controlled trials. Integr. Cancer Ther. 14:15–15
    [Google Scholar]
  32. Danhauer SC, Addington EL, Cohen L, Sohl SJ, Van Puymbroeck M et al. 2019. Yoga for symptom management in oncology: a review of the evidence base and future directions for research. Cancer 125:121979–89
    [Google Scholar]
  33. De Paolis G, Naccarato A, Cibelli F, D'Alete A, Mastroianni C et al. 2019. The effectiveness of progressive muscle relaxation and interactive guided imagery as a pain-reducing intervention in advanced cancer patients: a multicentre randomised controlled non-pharmacological trial. Complement. Ther. Clin. Pract. 34:280–87
    [Google Scholar]
  34. Dingley C, Ruckdeschel A, Kotula K, Lekhak N. 2021. Implementation and outcomes of complementary therapies in hospice care: an integrative review. Palliat. Care Soc. Pract. 15: https://doi.org/10.1177/26323524211051753
    [Crossref] [Google Scholar]
  35. Frankl VF. 1959. Man's Search for Meaning. Boston, MA: Beacon Press
    [Google Scholar]
  36. Gonzalez M, Pascoe MC, Yang G, de Manincor M et al. 2021. Yoga for depression and anxiety symptoms in people with cancer: a systematic review and meta-analysis. Psycho-Oncology 30:81196–208
    [Google Scholar]
  37. Goodwin PJ, Leszcz M, Ennis M, Koopmans J, Vincent L et al. 2001. The effect of group psychosocial support on survival in metastatic breast cancer. N. Engl. J. Med. 345:1719–26
    [Google Scholar]
  38. Greenlee H, DuPont-Reyes MJ, Balneaves LG, Carlson LE, Cohen MR et al. 2017. Clinical practice guidelines on the evidence-based use of integrative therapies during and after breast cancer treatment. CA Cancer J. Clin. 67:3194–232
    [Google Scholar]
  39. Griffiths RR, Johnson MW, Carducci MA, Umbricht A, Richards WA et al. 2016. Psilocybin produces substantial and sustained decreases in depression and anxiety in patients with life-threatening cancer: a randomized double-blind trial. J. Psychopharmacol. 30:121181–97
    [Google Scholar]
  40. Hales S, Lo C, Rodin G. 2010. Managing Cancer and Living Meaningfully (CALM) Treatment Manual: An Individual Psychotherapy for Patients with Advanced Cancer Toronto: Univ. Health Netw.
    [Google Scholar]
  41. Hayes SC, Strosahl KD, Wilson KG. 2009. Acceptance and Commitment Therapy Washington, DC: Am. Psychol. Assoc.
    [Google Scholar]
  42. Hong HC, Min A, Kim YM 2022. A systematic review and pooled prevalence of symptoms among childhood and adolescent and young adult cancer survivors. J. Clin. Nurs. In press. https://doi.org/10.1111/jocn.16201
    [Crossref] [Google Scholar]
  43. Hulbert-Williams NJ, Storey L, Wilson KG. 2015. Psychological interventions for patients with cancer: psychological flexibility and the potential utility of Acceptance and Commitment Therapy. Eur. J. Cancer Care 24:115–27
    [Google Scholar]
  44. Inst. Med. 2013. Delivering High-Quality Cancer Care: Charting a New Course for a System in Crisis Washington, DC: Natl. Acad. Press
    [Google Scholar]
  45. Kabat-Zinn J. 1990. Full Catastrophe Living New York: Delacorte Press
    [Google Scholar]
  46. Kapogiannis A, Tsoli S, Chrousos G. 2018. Investigating the effects of the progressive muscle relaxation-guided imagery combination on patients with cancer receiving chemotherapy treatment: a systematic review of randomized controlled trials. Explore 14:2137–43
    [Google Scholar]
  47. Kissane DW, Grabsch B, Clarke DM, Smith GC, Love AW et al. 2007. Supportive-expressive group therapy for women with metastatic breast cancer: survival and psychosocial outcome from a randomized controlled trial. Psycho-Oncology 16:4277–86
    [Google Scholar]
  48. Lehto RH, Miller M, Sender J. 2022. The role of psilocybin-assisted psychotherapy to support patients with cancer: a critical scoping review of the research. J. Holist. Nurs. 40:326580
    [Google Scholar]
  49. Li J, Liu Y, Jiang J, Peng X, Hu X. 2021. Effect of telehealth interventions on quality of life in cancer survivors: a systematic review and meta-analysis of randomized controlled trials. Int. J. Nurs. Stud. 122:103970
    [Google Scholar]
  50. Li J, Zhu C, Liu C, Su Y, Peng X, Hu X. 2022. Effectiveness of eHealth interventions for cancer-related pain, fatigue, and sleep disorders in cancer survivors: a systematic review and meta-analysis of randomized controlled trials. J. Nurs. Scholarsh. 54:2184–90
    [Google Scholar]
  51. Loudon K, Treweek S, Sullivan F, Donnan P, Thorpe KE, Zwarenstein M. 2015. The PRECIS-2 tool: designing trials that are fit for purpose. BMJ 350:h2147
    [Google Scholar]
  52. Ma Y, He B, Jiang M, Yang Y, Wang C et al. 2020. Prevalence and risk factors of cancer-related fatigue: a systematic review and meta-analysis. Int. J. Nurs. Stud. 111:103707
    [Google Scholar]
  53. Martínez M, Arantzamendi M, Belar A, Carrasco JM, Carvajal A et al. 2017.. “ Dignity therapy”, a promising intervention in palliative care: a comprehensive systematic literature review. Palliat. Med. 31:6492–509
    [Google Scholar]
  54. Mathew A, Doorenbos AZ, Jang MK, Hershberger PE. 2021. Acceptance and commitment therapy in adult cancer survivors: a systematic review and conceptual model. J. Cancer Surviv. 15:3427–51
    [Google Scholar]
  55. McConnell T, Porter S. 2017. Music therapy for palliative care: a realist review. Palliat. Support. Care 15:4454–64
    [Google Scholar]
  56. Mehnert A, Hartung TJ, Friedrich M, Vehling S, Brähler E et al. 2018. One in two cancer patients is significantly distressed: prevalence and indicators of distress. Psycho-Oncology 27:175–82
    [Google Scholar]
  57. Mehnert A, Koranyi S, Philipp R, Scheffold K, Kriston L et al. 2020. Efficacy of the Managing Cancer and Living Meaningfully (CALM) individual psychotherapy for patients with advanced cancer: a single-blind randomized controlled trial. Psycho-Oncology 29:111895–904
    [Google Scholar]
  58. Mitchell AJ, Chan M, Bhatti H, Halton M, Grassi L et al. 2011. Prevalence of depression, anxiety, and adjustment disorder in oncological, haematological, and palliative-care settings: a meta-analysis of 94 interview-based studies. Lancet Oncol. 12:2160–74
    [Google Scholar]
  59. Mitchell AJ, Ferguson DW, Gill J, Paul J, Symonds P. 2013. Depression and anxiety in long-term cancer survivors compared with spouses and healthy controls: a systematic review and meta-analysis. Lancet Oncol. 14:8721–32
    [Google Scholar]
  60. Mutsaers B, Rutkowski N, Jones G, Lamarche J, Lebel S. 2020. Assessing and managing patient fear of cancer recurrence. Can. Fam. Physician 66:9672–73
    [Google Scholar]
  61. NCCN (Natl. Compr. Cancer Netw.). 2022. NCCN guidelines. National Comprehensive Cancer Network https://www.nccn.org/guidelines/category_3
    [Google Scholar]
  62. Ni X, Chan RJ, Yates P, Hu W, Huang X, Lou Y. 2019. The effects of Tai Chi on quality of life of cancer survivors: a systematic review and meta-analysis. Support. Care Cancer 27:103701–16
    [Google Scholar]
  63. O'Neill M, Samaroo D, Lopez C, Tomlinson G, Santa Mina D et al. 2020. The effect of yoga interventions on cancer-related fatigue and quality of life for women with breast cancer: a systematic review and meta-analysis of randomized controlled trials. Integr. Cancer Ther. 19:1534735420959882
    [Google Scholar]
  64. Pedro J, Monteiro-Reis S, Carvalho-Maia C, Henrique R, Jerónimo C, Silva ER 2021. Evidence of psychological and biological effects of structured Mindfulness-Based Interventions for cancer patients and survivors: a meta-review. Psycho-Oncology 30:111836–48
    [Google Scholar]
  65. Riedl D, Schuessler G. 2021. Prevalence of depression and cancer—a systematic review. Z. Psychosom. Med. Psychother. 68:1 https://doi.org/10.13109/zptm.2021.67.oa11
    [Crossref] [Google Scholar]
  66. Rodin G, Lo C, Rydall A, Shnall J, Malfitano C et al. 2018. Managing Cancer and Living Meaningfully (CALM): a randomized controlled trial of a psychological intervention for patients with advanced cancer. J. Clin. Oncol. 36:2422–32
    [Google Scholar]
  67. Ross S, Agin-Liebes G, Lo S, Zeifman RJ, Ghazal L et al. 2021. Acute and sustained reductions in loss of meaning and suicidal ideation following psilocybin-assisted psychotherapy for psychiatric and existential distress in life-threatening cancer. ACS Pharmacol. Trans. Sci. 4:2553–62
    [Google Scholar]
  68. Ross S, Bossis A, Guss J, Agin-Liebes G, Malone T et al. 2016. Rapid and sustained symptom reduction following psilocybin treatment for anxiety and depression in patients with life-threatening cancer: a randomized controlled trial. J. Psychopharmacol. 30:121165–80
    [Google Scholar]
  69. Rowland JH. 2008. Cancer survivorship: rethinking the cancer control continuum. Semin. Oncol. Nurs. 24:3145–52
    [Google Scholar]
  70. Savard J, Villa J, Ivers H, Simard S, Morin CM. 2009. Prevalence, natural course, and risk factors of insomnia comorbid with cancer over a 2-month period. J. Clin. Oncol. 27:315233–39
    [Google Scholar]
  71. Schmidt ME, Hermann S, Arndt V, Steindorf K. 2020. Prevalence and severity of long-term physical, emotional, and cognitive fatigue across 15 different cancer entities. Cancer Med. 9:218053–61
    [Google Scholar]
  72. Shapiro SL, Carlson LE. 2017. The Art and Science of Mindfulness: Integrating Mindfulness into Psychology and the Helping Professions Washington, DC: Am. Psychol. Assoc., 2nd ed..
    [Google Scholar]
  73. Simard S, Thewes B, Humphris G, Dixon M, Hayden C et al. 2013. Fear of cancer recurrence in adult cancer survivors: a systematic review of quantitative studies. J. Cancer Surviv. 7:3300–22
    [Google Scholar]
  74. Speca M, Carlson LE, Goodey E, Angen M. 2000. A randomized, wait-list controlled clinical trial: the effect of a mindfulness meditation-based stress reduction program on mood and symptoms of stress in cancer outpatients. Psychosom. Med. 62:5613–22
    [Google Scholar]
  75. Spiegel D, Kraemer H, Bloom J, Gottheil E. 1989. Effect of psychosocial treatment on survival of patients with metastatic breast cancer. Lancet 334:8668888–91
    [Google Scholar]
  76. Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I et al. 2021. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J. Clin. 71:3209–49
    [Google Scholar]
  77. Thong MS, van Noorden CJ, Steindorf K, Arndt V. 2020. Cancer-related fatigue: causes and current treatment options. Curr. Treat. Options Oncol. 21:21–19
    [Google Scholar]
  78. Tian X, Tang R-Y, Xu L-L, Xie W, Chen H et al. 2020. Progressive muscle relaxation is effective in preventing and alleviating of chemotherapy-induced nausea and vomiting among cancer patients: a systematic review of six randomized controlled trials. Support. Care Cancer 28:94051–58
    [Google Scholar]
  79. Traeger L, Cannon S, Keating NL, Pirl WF, Lathan C et al. 2014. Race by sex differences in depression symptoms and psychosocial service use among non-Hispanic black and white patients with lung cancer. J. Clin. Oncol. 32:2107–13
    [Google Scholar]
  80. Treanor CJ, Santin O, Prue G, Coleman H, Cardwell CR et al. 2019. Psychosocial interventions for informal caregivers of people living with cancer. Cochrane Database Syst. Rev. 6:CD009912
    [Google Scholar]
  81. van den Beuken-van Everdingen MHJ, de Rijke JM, Kessels AG, Schouten HC et al. 2007. Prevalence of pain in patients with cancer: a systematic review of the past 40 years. Ann. Oncol. 18:91437–49
    [Google Scholar]
  82. Vowles KE, McCracken LM. 2010. Comparing the role of psychological flexibility and traditional pain management coping strategies in chronic pain treatment outcomes. Behav. Res. Ther. 48:2141–46
    [Google Scholar]
  83. Wachholtz AB, Fitch CE, Makowski S, Tjia J. 2016. A comprehensive approach to the patient at end of life: assessment of multidimensional suffering. South. Med. J. 109:4200–6
    [Google Scholar]
  84. Walker ZJ, Xue S, Jones MP, Ravindran AV. 2021. Depression, anxiety, and other mental disorders in patients with cancer in low- and lower-middle-income countries: a systematic review and meta-analysis. JCO Glob. Oncol. 7:1233–50
    [Google Scholar]
  85. Warth M, Zöller J, Köhler F, Aguilar-Raab C, Kessler J, Ditzen B. 2020. Psychosocial interventions for pain management in advanced cancer patients: a systematic review and meta-analysis. Curr. Oncol. Rep. 22:3
    [Google Scholar]
  86. Wayne PM, Lee MS, Novakowski J, Osypiuk K, Ligibel J et al. 2018. Tai Chi and Qigong for cancer-related symptoms and quality of life: a systematic review and meta-analysis. J. Cancer Surviv. Res. Pract. 12:2256–67
    [Google Scholar]
  87. Witt CM, Balneaves LG, Cardoso MJ, Cohen L, Greenlee H et al. 2017. A comprehensive definition for integrative oncology. JNCI Monogr. 2017:523–8
    [Google Scholar]
  88. Zhang Q, Zhao H, Zheng Y. 2019. Effectiveness of mindfulness-based stress reduction (MBSR) on symptom variables and health-related quality of life in breast cancer patients—a systematic review and meta-analysis. Support. Care Cancer 27:3771–81
    [Google Scholar]
  89. Zhao C, Lai L, Zhang L, Cai Z, Ren Z et al. 2021. The effects of acceptance and commitment therapy on the psychological and physical outcomes among cancer patients: a meta-analysis with trial sequential analysis. J. Psychosom. Res. 140:110304
    [Google Scholar]
  90. Zhou C, Wu Y, An S, Li X 2015. Effect of expressive writing intervention on health outcomes in breast cancer patients: a systematic review and meta-analysis of randomized controlled trials. PLOS ONE 10:7e0131802
    [Google Scholar]
/content/journals/10.1146/annurev-psych-032620-031757
Loading
/content/journals/10.1146/annurev-psych-032620-031757
Loading

Data & Media loading...

  • Article Type: Review Article
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error