1932

Abstract

The cumulative science linking stress to negative health outcomes is vast. Stress can affect health directly, through autonomic and neuroendocrine responses, but also indirectly, through changes in health behaviors. In this review, we present a brief overview of () why we should be interested in stress in the context of health; () the stress response and allostatic load; () some of the key biological mechanisms through which stress impacts health, such as by influencing hypothalamic-pituitary-adrenal axis regulation and cortisol dynamics, the autonomic nervous system, and gene expression; and () evidence of the clinical relevance of stress, exemplified through the risk of infectious diseases. The studies reviewed in this article confirm that stress has an impact on multiple biological systems. Future work ought to consider further the importance of early-life adversity and continue to explore how different biological systems interact in the context of stress and health processes.

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2021-01-04
2024-10-09
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Literature Cited

  1. Adam EK, Doane LD, Zinbarg RE, Mineka S, Craske MG, Griffith JW 2010. Prospective prediction of major depressive disorder from cortisol awakening responses in adolescence. Psychoneuroendocrinology 35:921–31
    [Google Scholar]
  2. Adam EK, Quinn ME, Tavernier R, McQuillan MT, Dahlke KA, Gilbert KE 2017. Diurnal cortisol slopes and mental and physical health outcomes: a systematic review and meta-analysis. Psychoneuroendocrinology 83:25–41The first review and meta-analysis of the relationships between diurnal cortisol and health outcomes.
    [Google Scholar]
  3. al'Absi M, Wittmers LE Jr 2003. Enhanced adrenocortical responses to stress in hypertension-prone men and women. Ann. Behav. Med. 25:25–33
    [Google Scholar]
  4. Am. Psychol. Assoc 2019. Stress in America 2019 Washington, DC: Am. Psychol. Assoc.
    [Google Scholar]
  5. Ansorge S, Schön E. 1987. Dipeptidyl peptidase IV (DP IV), a functional marker of the T lymphocyte system. Acta Histochem 82:41–46
    [Google Scholar]
  6. Antoni MH, Lutgendorf SK, Blomberg B, Carver CS, Lechner S et al. 2012. Cognitive-behavioral stress management reverses anxiety-related leukocyte transcriptional dynamics. Biol. Psychiatry 71:366–72
    [Google Scholar]
  7. Beauchaine TP, Thayer JF. 2015. Heart rate variability as a transdiagnostic biomarker of psychopathology. Int. J. Psychophysiol. 98:338–50
    [Google Scholar]
  8. Bellis MA, Hughes K, Leckenby N, Hardcastle KA, Perkins C, Lowey H 2015. Measuring mortality and the burden of adult disease associated with adverse childhood experiences in England: a national survey. J. Public Health 37:445–54
    [Google Scholar]
  9. Benarroch EE. 2008. The arterial baroreflex: functional organization and involvement in neurologic disease. Neurology 71:1733–38
    [Google Scholar]
  10. Ben-Dov IZ, Kark JD, Ben-Ishay D, Mekler J, Ben-Arie L, Bursztyn M 2007. Blunted heart rate dip during sleep and all-cause mortality. Arch. Intern. Med. 167:2116–21
    [Google Scholar]
  11. Bernard K, Frost A, Bennett CB, Lindhiem O 2017. Maltreatment and diurnal cortisol regulation: a meta-analysis. Psychoneuroendocrinology 78:57–67
    [Google Scholar]
  12. Black DS, Cole SW, Irwin MR, Breen E, Cyr NMS et al. 2013. Yogic meditation reverses NF-κB and IRF-related transcriptome dynamics in leukocytes of family dementia caregivers in a randomized controlled trial. Psychoneuroendocrinology 38:348–55
    [Google Scholar]
  13. Boggero IA, Hostinar CE, Haak EA, Murphy MLM, Segerstrom S 2017. Psychosocial functioning and the cortisol awakening response: meta-analysis, P-curve analysis and evaluation of the evidential value of existing studies. Biol. Psychol. 129:207–30
    [Google Scholar]
  14. Bower JE, Greendale G, Crosswell AD, Garet D, Sternlieb B et al. 2014. Yoga reduces inflammatory signaling in fatigued breast cancer survivors: a randomized controlled trial. Psychoneuroendocrinology 43:20–29
    [Google Scholar]
  15. Brosschot JF, Verkuil B, Thayer JF 2016. The default response to uncertainty and the importance of perceived safety in anxiety and stress: an evolution-theoretical perspective. J. Anxiety Disord. 41:22–34
    [Google Scholar]
  16. Brosschot JF, Verkuil B, Thayer JF 2017. Exposed to events that never happen: generalized unsafety, the default stress response, and prolonged autonomic activity. Neurosci. Biobehav. Rev. 74:287–96
    [Google Scholar]
  17. Brosschot JF, Verkuil B, Thayer JF 2018. Generalized unsafety theory of stress: unsafe environments and conditions, and the default stress response. Int. J. Environ. Res. Public Health 15:464Comprehensive overview of an important new theory of stress.
    [Google Scholar]
  18. Bunea I, Szentágotai-Tătar A, Miu AC 2017. Early-life adversity and cortisol response to social stress: a meta-analysis. Transl. Psychiatry 7:1274
    [Google Scholar]
  19. Carpenter LL, Carvalho JP, Tyrka AR, Wier LM, Mello AF et al. 2007. Decreased adrenocorticotropic hormone and cortisol responses to stress in healthy adults reporting significant childhood maltreatment. Biol. Psychiatry 62:1080–87
    [Google Scholar]
  20. Carpenter LL, Shattuck TT, Tyrka AR, Geracioti TD, Price LH 2011. Effect of childhood physical abuse on cortisol stress response. Psychopharmacology 214:367–75
    [Google Scholar]
  21. Carr CP, Martins CM, Stingel AM, Lemgruber VB, Juruena MF 2013. The role of early life stress in adult psychiatric disorders: a systematic review according to childhood trauma subtypes. J. Nerv. Ment. Dis. 201:1007–20
    [Google Scholar]
  22. Carroll D, Ginty AT, Whittaker AC, Lovallo WR, de Rooij SR 2017. The behavioural, cognitive, and neural corollaries of blunted cardiovascular and cortisol reactions to acute psychological stress. Neurosci. Biobehav. Rev. 77:74–86
    [Google Scholar]
  23. Chida Y, Steptoe A. 2009. Cortisol awakening response and psychosocial factors: a systematic review and meta-analysis. Biol. Psychol. 80:265–78
    [Google Scholar]
  24. Clancy F, Prestwich A, Caperon L, O'Connor DB 2016. Perseverative cognition and health behaviours: a systematic review and meta-analysis. Front. Hum. Neurosci. 10:534The first paper to extend the perseverative cognition hypothesis to health behaviors.
    [Google Scholar]
  25. Clancy F, Prestwich A, Caperon L, Tsipa A, O'Connor DB 2020. The association between perseverative cognition and sleep in non-clinical populations: a systematic review and meta-analysis. Health Psychol. Rev. In press. https://doi.org/10.1080/17437199.2019.1700819
    [Crossref] [Google Scholar]
  26. Clow A, Hucklebridge F, Stalder T, Evans P, Thorn L 2010. The cortisol awakening response: more than a measure of HPA axis function. Neurosci. Biobehav. Rev. 35:97–103
    [Google Scholar]
  27. Cohen S. 2005. Keynote presentation at the Eight International Congress of Behavioral Medicine. Int. J. Behav. Med. 12:123–31
    [Google Scholar]
  28. Cohen S, Doyle WJ, Skoner DP, Rabin BS, Gwaltney JM 1997. Social ties and susceptibility to the common cold. JAMA 277:1940–44
    [Google Scholar]
  29. Cohen S, Frank E, Doyle WJ, Skoner DP, Rabin BS, Gwaltney JM Jr 1998. Types of stressors that increase susceptibility to the common cold in healthy adults. Health Psychol 17:214–23
    [Google Scholar]
  30. Cohen S, Gianaros PJ, Manuck SB 2016. A stage model of stress and disease. Perspect. Psychol. Sci. 11:456–63
    [Google Scholar]
  31. Cohen S, Janicki-Deverts D, Doyle WJ, Miller GE, Frank E et al. 2012. Chronic stress, glucocorticoid receptor resistance, inflammation, and disease risk. PNAS 109:5995–99
    [Google Scholar]
  32. Cohen S, Janicki-Deverts D, Turner RB, Doyle WJ 2015. Does hugging provide stress-buffering social support? A study of susceptibility to upper respiratory infection and illness. Psychol. Sci. 26:135–47
    [Google Scholar]
  33. Cohen S, Miller GE, Rabin BS 2001. Psychological stress and antibody response to immunization: a critical review of the human literature. Psychosom. Med. 63:7–18
    [Google Scholar]
  34. Cohen S, Tyrrell DA, Smith AP 1991. Psychological stress and susceptibility to the common cold. N. Engl. J. Med. 325:606–12The first study to show that increases in psychological stress are associated with increased risk of developing a common cold.
    [Google Scholar]
  35. Cole SW. 2013. Social regulation of human gene expression: mechanisms and implications for public health. Am. J. Public Health 103:S84–92
    [Google Scholar]
  36. Cole SW. 2019. The conserved transcriptional response to adversity. Curr. Opin. Behav. Sci. 28:31–37
    [Google Scholar]
  37. Cole SW, Capitanio JP, Chun K, Arevalo JMG, Ma J, Cacioppo JT 2015. Myeloid differentiation architecture of leukocyte transcriptome dynamics in perceived social isolation. PNAS 112:15142–47
    [Google Scholar]
  38. Cole SW, Hawkley LC, Arevalo JMG, Cacioppo JT 2011. Transcript origin analysis identifies antigen-presenting cells as primary targets of socially regulated gene expression in leukocytes. PNAS 108:3080–85
    [Google Scholar]
  39. Cole SW, Hawkley LC, Arevalo JMG, Sung CY, Rose RM, Cacioppo JT 2007. Social regulation of gene expression in human leukocytes. Genome Biol 8:R189The first study to show that gene expression is influenced by different levels of loneliness.
    [Google Scholar]
  40. Craske MG, Wolitzky-Taylor KB, Mineka S, Zinbarg R, Waters AM et al. 2012. Elevated responding to safe conditions as a specific risk factor for anxiety versus depressive disorders: evidence from a longitudinal investigation. J. Abnorm. Psychol. 121:315–24
    [Google Scholar]
  41. Creswell JD, Irwin MR, Burklund LJ, Lieberman MD, Arevalo JM et al. 2012. Mindfulness-based stress reduction training reduces loneliness and pro-inflammatory gene expression in older adults: a small randomized controlled trial. Brain. Behav. Immun. 26:1095–101
    [Google Scholar]
  42. Cruz-Pereira JS, Rea K, Nolan YM, O'Leary OF, Dinan TG, Cryan JF 2020. Depression's unholy trinity: dysregulated stress, immunity, and the microbiome. Annu. Rev. Psychol. 71:49–78
    [Google Scholar]
  43. Cuspidi C, Giudici V, Negri F, Sala C 2010. Nocturnal nondipping and left ventricular hypertrophy in hypertension: an updated review. Exp. Rev. Cardiovasc. Ther. 8:781–92
    [Google Scholar]
  44. Danese A, Baldwin JR. 2017. Hidden wounds? Inflammatory links between childhood trauma and psychopathology. Annu. Rev. Psychol. 68:517–44
    [Google Scholar]
  45. Danese A, McEwen BS. 2012. Adverse childhood experiences, allostasis, allostatic load and age-related disease. Phys. Behav. 106:29–39
    [Google Scholar]
  46. Dauphinot V, Gosse P, Kossovsky MP, Schott AM, Rouch I et al. 2010. Autonomic nervous system activity is independently associated with the risk of shift in the non-dipper blood pressure pattern. Hypertens. Res. 33:1032–37
    [Google Scholar]
  47. De Rooij SR. 2013. Blunted cardiovascular and cortisol reactivity to acute psychological stress: a summary of results from the Dutch Famine Birth Cohort Study. Int. J. Psychophysiol. 90:21–27
    [Google Scholar]
  48. De Vugt ME, Nicolson NA, Aalten P, Lousberg R, Jolle J, Verhey FR 2005. Behavioral problems in dementia patients and salivary cortisol patterns in caregivers. J. Neuropsychiat. Clin. Neurosci. 17:201–7
    [Google Scholar]
  49. Dickerson SS, Kemeny ME. 2004. Acute stressors and cortisol responses: a theoretical integration and synthesis of laboratory research. Psychol. Bull. 130:355–91
    [Google Scholar]
  50. Edwards KM, Burns VE, Allen LM, McPhee JS, Bosch JA et al. 2007. Eccentric exercise as an adjuvant to influenza vaccination in humans. Brain Behav. Immun. 21:209–17
    [Google Scholar]
  51. Edwards KM, Burns VE, Reynolds T, Carroll D, Drayson M, Ring C 2006. Acute stress exposure prior to influenza vaccination enhances antibody response in women. Brain Behav. Immun. 20:159–68
    [Google Scholar]
  52. Fallo F, Barzon L, Rabbia F, Navarrini C, Conterno A et al. 2002. Circadian blood pressure patterns and life stress. Psychother. Psychosom. 71:350–56
    [Google Scholar]
  53. Fan LB, Blumenthal JA, Hinderliter AL, Sherwood A 2013. The effect of job strain on nighttime blood pressure dipping among men and women with high blood pressure. Scand. J. Work Environ. Health 39:112
    [Google Scholar]
  54. Fortmann AL, Gallo LC. 2013. Social support and nocturnal blood pressure dipping: a systematic review. Am. J. Hypertens. 26:302–10
    [Google Scholar]
  55. Fries E, Dettenborn L, Kirschbaum C 2009. The cortisol awakening response (CAR): facts and future directions. Int. J. Psychophysiol. 72:67–73
    [Google Scholar]
  56. Gartland N, O'Connor DB, Lawton R, Bristow M 2014. Exploring day-to-day dynamics of daily stressor appraisals, physical symptoms and the cortisol awakening response. Psychoneuroendocrinology 50:130–38
    [Google Scholar]
  57. Gasperin D, Netuveli G, Dias-da-Costa JS, Pattussi MP 2009. Effect of psychological stress on blood pressure increase: a meta-analysis of cohort studies. Cad. Saude Publica 25:715–26
    [Google Scholar]
  58. Gerritsen L, Geerlings MI, Beekman AT, Deeg DJ, Penninx BW, Comijs HC 2010. Early and late life events and salivary cortisol in older persons. Psychol. Med. 40:1569–78
    [Google Scholar]
  59. Glaser R, Kiecolt-Glaser JK, Bonneau RH, Malarkey W, Kennedy S, Hughes J 1992. Stress-induced modulation of the immune response to recombinant hepatitis B vaccine. Psychosom. Med. 54:22–29
    [Google Scholar]
  60. Hall M, Vasko R, Buysse D, Ombao H, Chen Q et al. 2004. Acute stress affects heart rate variability during sleep. Psychosom. Med. 66:56–62
    [Google Scholar]
  61. Hamer M, Endrighi R, Venuraju SM, Lahiri A, Steptoe A 2012. Cortisol responses to mental stress and the progression of coronary artery calcification in healthy men and women. PLOS ONE 7:e31356
    [Google Scholar]
  62. Hamer M, O'Donnell K, Lahiri A, Steptoe A 2010. Salivary cortisol responses to mental stress are associated with coronary artery calcification in healthy men and women. Eur. Heart J. 31:424–29
    [Google Scholar]
  63. Hamer M, Steptoe A. 2012. Cortisol responses to mental stress and incident hypertension in healthy men and women. J. Clin. Endocrinol. Metab. 97:E29–34
    [Google Scholar]
  64. Hill DC, Moss RH, Sykes-Muskett B, Conner M, O'Connor DB 2018. Stress and eating behaviors in children and adolescents: systematic review and meta-analysis. Appetite 123:14–22
    [Google Scholar]
  65. Hughes K, Bellis MA, Hardcastle KA, Sethi D, Butchart A et al. 2017. The effect of multiple adverse childhood experiences on health: a systematic review and meta-analysis. Lancet Public Health 2:e356–66
    [Google Scholar]
  66. Jarczok MN, Jarczok M, Mauss D, Koenig J, Li J, Herr RM, Thayer JF 2013. Autonomic nervous system activity and workplace stressors—a systematic review. Neurosci. Biobehav. Rev 37:1810–23
    [Google Scholar]
  67. Jarczok MN, Jarczok M, Thayer JF 2020. Work stress and autonomic nervous system activity. Handbook of Socioeconomic Determinants of Occupational Healthed. T Theorellpp. 62556 Cham, Switz: Springer Int. Publ.
    [Google Scholar]
  68. Jarczok MN, Koenig J, Wittling A, Fischer JE, Thayer JF 2019. First evaluation or an index of low vagally-mediated heart rate variability as a marker of health risks in human adults: proof of concept. J. Clin. Med. 8:1940
    [Google Scholar]
  69. Julius S. 1995. The defense reaction: a common denominator of coronary risk and blood pressure in neurogenic hypertension. Clin. Exp. Hypertens. 17:375–86
    [Google Scholar]
  70. Kagan J. 2016. An overly permissive extension. Perspect. Psychol. Sci. 11:442–50
    [Google Scholar]
  71. Kirschbaum C, Pirke K-M, Hellhammer DH 1993. The “Trier Social Stress Test”—a tool for investigating psychobiological stress responses in a laboratory setting. Neuropsychobiol 28:76–81One of the most popular techniques to induce stress in the laboratory.
    [Google Scholar]
  72. Kivimäki M, Steptoe A. 2018. Effects of stress on the development and progression of cardiovascular disease. Nat. Rev. Cardiol. 15:215
    [Google Scholar]
  73. Krantz DS, Manuck SB. 1984. Acute psychophysiologic reactivity and risk of cardiovascular disease: a review and methodologic critique. Psychol. Bull. 96:435–64
    [Google Scholar]
  74. Landsbergis PA, Dobson M, Koutsouras G, Schnall P 2013. Job strain and ambulatory blood pressure: a meta-analysis and systematic review. Am. Public Health 103:e61–71
    [Google Scholar]
  75. Lazarus RS. 1999. Stress and Emotion: A New Synthesis New York: Springer
    [Google Scholar]
  76. Lob E, Steptoe A. 2019. Cardiovascular disease and hair cortisol: a novel biomarker of chronic stress. Curr. Cardiol. Rep. 21:116
    [Google Scholar]
  77. Loerbroks A, Schilling O, Haxsen V, Jarczok MN, Thayer JF, Fischer JE 2010. The fruits of one's labor: Effort-reward imbalance but not job strain is related to heart rate variability across the day in 35–44-year-old workers. J. Psychosom. Res. 69:151–59
    [Google Scholar]
  78. Lovallo WR. 2013. Early life adversity reduces stress reactivity and enhances impulsive behavior: implications for health behaviors. Int. J. Psychophysiol. 90:8–16
    [Google Scholar]
  79. Lovallo WR. 2016. Stress and Health: Biological and Psychological Interactions Thousand Oaks, CA: SAGE. , 3rd ed..
    [Google Scholar]
  80. Lovallo WR, Cohoon AJ, Sorocco KH, Vincent AS, Acheson A et al. 2019. Early‐life adversity and blunted stress reactivity as predictors of alcohol and drug use in persons with COMT (rs4680) Val158Met genotypes. Alcohol. Clin. Exp. Res. 43:1519–27
    [Google Scholar]
  81. Lovallo WR, Dickensheets SL, Myers DA, Thomas TL, Nixon SJ 2000. Blunted stress cortisol response in abstinent alcoholic and polysubstance-abusing men. Alcohol. Clin. Exp. Res. 24:651–58Early study showing that a blunted cortisol response may be a marker of HPA axis dysregulation.
    [Google Scholar]
  82. Lovallo WR, Farag NH, Sorocco KH, Acheson A, Cohoon AJ, Vincent AS 2013. Early life adversity contributes to impaired cognition and impulsive behaviour: studies from the Oklahoma Family Health Patterns Project. Alcohol. Clin. Exp. Res. 37:616–23
    [Google Scholar]
  83. Lupien SJ, McEwen BS, Gunnar MR, Heim C 2009. Effects of stress throughout the lifespan on the brain, behaviour and cognition. Nat. Rev. Neurosci. 10:434–45
    [Google Scholar]
  84. Manuck SB, Krantz DS. 1984. Psychophysiologic reactivity in coronary heart disease. Behav. Med. Update 6:11–15
    [Google Scholar]
  85. Marmot M, Brunner E. 2005. Cohort profile: the Whitehall II study. Int. J. Epidemiol. 34:251–56
    [Google Scholar]
  86. Marsland AL, Cohen S, Rabin BS, Manuck SB 2006. Trait positive affect and antibody response to hepatitis B vaccination. Brain Behav. Immun. 20:261–69
    [Google Scholar]
  87. Massey AJ, Campbell BK, Raine-Fenning N, Pincott-Allen C, Perry J, Vedhara K 2016. Relationship between hair and salivary cortisol and pregnancy in women undergoing IVF. Psychoneuroendocrinology 74:397–405
    [Google Scholar]
  88. Matthews K, Schwartz J, Cohen S, Seeman T 2006. Diurnal cortisol decline is related to coronary calcification: CARDIA study. Psychosom. Med. 68:657–61
    [Google Scholar]
  89. Mayne SL, Moore KA, Powell-Wiley TM, Evenson KR, Block R, Kershaw KN 2018. Longitudinal associations of neighborhood crime and perceived safety with blood pressure: the Multi-Ethnic Study of Atherosclerosis (MESA). Am. J. Hypertens. 31:1024–32
    [Google Scholar]
  90. McEwen BS. 1998. Protective and damaging effects of stress mediators. N. Engl. J. Med. 338:171–79Very influential overview of allostasis and allostatic load.
    [Google Scholar]
  91. McEwen BS. 2000. Allostasis and allostatic load: implications for neuropsychopharmacology. Neuropsychopharmacology 22:108–24
    [Google Scholar]
  92. McEwen BS. 2018. Redefining neuroendocrinology: epigenetics of brain-body communication over the life course. Front. Neuroendocrinol. 49:8–30
    [Google Scholar]
  93. McEwen BS. 2019. What is the confusion with cortisol. Chronic Stress 3:1–3
    [Google Scholar]
  94. McEwen BS, McEwen CA. 2016. Response to Jerome Kagan's Essay on Stress (2016). Perspect. Psychol. Sci. 11:451–55
    [Google Scholar]
  95. McEwen BS, Seeman T. 1999. Protective and damaging effects of mediators of stress: elaborating and testing the concepts of allostasis and allostatic load. Ann. N.Y. Acad. Sci. 896:30–47
    [Google Scholar]
  96. Mehl MR, Raison CL, Pace TW, Arevalo JM, Cole SW 2017. Natural language indicators of differential gene regulation in the human immune system. PNAS 114:12554–59
    [Google Scholar]
  97. Miller GE, Chen E. 2006. Life stress and diminished expression of genes encoding glucocorticoid receptor and β2-adrenergic receptor in children with asthma. PNAS 103:5496–501
    [Google Scholar]
  98. Miller GE, Chen E, Sze J, Marin T, Arevalo JM et al. 2008. A functional genomic fingerprint of chronic stress in humans: blunted glucocorticoid and increased NF-κB signaling. Biol. Psychiatry 64:266–72
    [Google Scholar]
  99. Miller GE, Chen E, Zhou ES 2007. If it goes up, must it come down? Chronic stress and the hypothalamic-pituitary-adrenocortical axis in humans. Psychol. Bull. 133:25–45
    [Google Scholar]
  100. Miller GE, Cohen S, Ritchey AK 2002. Chronic psychological stress and the regulation of pro-inflammatory cytokines: a glucocorticoid-resistance model. Health Psychol 21:531
    [Google Scholar]
  101. Miller GE, Murphy ML, Cashman R, Ma R, Ma J et al. 2014. Greater inflammatory activity and blunted glucocorticoid signaling in monocytes of chronically stressed caregivers. Brain Behav. Immun. 41:191–99
    [Google Scholar]
  102. Mortensen J, Dich N, Clark AJ, Ramlau-Hansen C, Head J et al. 2019. Informal caregiving and diurnal patterns of salivary cortisol: results from the Whitehall II cohort study. Psychoneuroendocrinology 100:41–47
    [Google Scholar]
  103. Nater UM, Youngblood LS, Jones JF, Unger ER, Miller AH et al. 2008. Alterations in diurnal salivary cortisol rhythm in a population-based sample of cases with chronic fatigue syndrome. Psychosom. Med. 70:298–305
    [Google Scholar]
  104. Newman E, O'Connor DB, Conner M 2007. Daily hassles and eating behaviour: the role of cortisol reactivity. Psychoneuroendocrinology 32:125–32
    [Google Scholar]
  105. Obrist PA. 1981. Cardiovascular Psychophysiology: A Perspective New York: Plenum Press
    [Google Scholar]
  106. O'Connor DB, Archer J, Hair WM, Wu FCW 2001. Activational effects of testosterone on cognitive function in men. Neuropsychologia 39:1385–94
    [Google Scholar]
  107. O'Connor DB, Branley-Bell D, Green J, Ferguson E, O'Carroll R, O'Connor RC 2020a. Effects of childhood trauma, daily stress and emotions on daily cortisol levels in individuals vulnerable to suicide. J. Abnorm. Psychol. 129:92–107
    [Google Scholar]
  108. O'Connor DB, Ferguson E, Green J, O'Carroll RE, O'Connor RC 2016. Cortisol and suicidal behavior: a meta-analysis. Psychoneuroendocrinology 63:370–79
    [Google Scholar]
  109. O'Connor DB, Gartland N, O'Connor RC 2020b. Stress, cortisol and suicide risk. Int. Rev. Neurobiol. 152:101–30
    [Google Scholar]
  110. O'Connor DB, Green J, Ferguson E, O'Carroll RE, O'Connor RC 2017. Cortisol reactivity and suicidal behavior: investigating the role of hypothalamic-pituitary-adrenal (HPA) axis responses to stress in suicide attempters and ideations. Psychoneuroendocrinology 75:183–91
    [Google Scholar]
  111. O'Connor DB, Green J, Ferguson E, O'Carroll RE, O'Connor RC 2018. Effects of childhood trauma on cortisol levels in suicide attempters and ideations. Psychoneuroendocrinology 88:9–16
    [Google Scholar]
  112. O'Connor DB, Hendrickx H, Dadd T, Talbot D, Mayes A et al. 2009. Cortisol awakening rise in middle-aged women in relation to chronic psychological stress. Psychoneuroendocrinology 34:1486–94
    [Google Scholar]
  113. O'Connor DB, Jones F, Conner M, McMillan B, Ferguson E 2008. Effects of daily hassles and eating style on eating behavior. Health Psychol 27:S20–31
    [Google Scholar]
  114. O'Connor DB, Walker S, Hendrickx H, Talbot D, Schaefer A 2013. Stress-related thinking predicts the cortisol awakening response and somatic symptoms in healthy adults. Psychoneuroendocrinology 38:438–46
    [Google Scholar]
  115. Ottaviani C, Thayer JF, Verkuil B, Lonigro A, Medea B et al. 2015. Physiological concomitants of perseverative cognition: a systematic review and meta-analysis. Psychol. Bull. 142:231–59
    [Google Scholar]
  116. Padden C, Concialdi-McGlynn C, Lydon S 2019. Psychophysiological measures of stress in caregivers of individuals with autism spectrum disorder: a system review. Dev. Neurorehabilit. 22:149–63
    [Google Scholar]
  117. Pakulak E, Stevens C, Neville H 2018. Neuro-, cardio-, and immunoplasticity: effects of early adversity. Annu. Rev. Psychol. 69:131–56
    [Google Scholar]
  118. Pedersen AF, Zachariae R, Bovbjerg DH 2009. Psychological stress and antibody response to influenza vaccination: a meta-analysis. Brain Behav. Immun. 23:427–33
    [Google Scholar]
  119. Plotkin SA. 2010. Correlates of protection induced by vaccination. Clin. Vaccine Immunol. 17:1055–65
    [Google Scholar]
  120. Powell DJ, Schlotz W. 2012. Daily life stress and the cortisol awakening response: testing the anticipation hypothesis. PLOS ONE 7:e52067
    [Google Scholar]
  121. Power C, Thomas C, Li L, Hertzman C 2012. Childhood psychosocial adversity and adult cortisol patterns. Br. J. Psychiatry 201:199–206
    [Google Scholar]
  122. Pruessner JC, Wolf OT, Hellhammer DH, Buske Kirschbaum A, von Auer K et al. 1997. Free cortisol levels after awakening: a reliable biological marker for the assessment of adrenocortical activity. Life Sci 61:2539–49
    [Google Scholar]
  123. Raison CL, Miller AH. 2003. When not enough is too much: the role of insufficient glucocorticoid signaling in the pathophysiology of stress-related disorders. Am. J. Psychiatry 160:1554–65
    [Google Scholar]
  124. Raul J-S, Cirimele V, Ludes B, Kintz P 2004. Detection of physiological concentrations of cortisol and cortisone in human hair. Clin. Biochem. 37:1105–11
    [Google Scholar]
  125. Roseboom T, de Rooij S, Painter R 2006. The Dutch famine and its long-term consequences for adult health. Early Hum. Dev. 82:485–91
    [Google Scholar]
  126. Ruttle PL, Javaras KN, Klein MH, Armstrong JM, Burk LR, Essex MJ 2013. Concurrent and longitudinal associations between diurnal cortisol and body mass index across adolescence. J. Adolesc. Health 52:731–37
    [Google Scholar]
  127. Salles GF, Ribeiro FM, Guimarães GM, Muxfeldt ES, Cardoso CR 2014. A reduced heart rate variability is independently associated with a blunted nocturnal blood pressure fall in patients with resistant hypertension. J. Hypertens. 32:644–51
    [Google Scholar]
  128. Sapolsky RM, Romero LM, Munck AU 2000. How do glucocorticoids influence stress responses? Integrating permissive, suppressive, stimulatory, and preparative actions. Endocr. Rev. 21:55–89
    [Google Scholar]
  129. Schmidt-Reinwald A, Pruessner JC, Hellhammer DH et al. 1999. The cortisol response to awakening in relation to different challenge tests and a 12-hour cortisol rhythm. Life Sci 64:1653–60
    [Google Scholar]
  130. Schrepf A, O'Donnell M, Luo Y, Bradley CS, Kreder K et al. 2014. Inflammation and inflammatory control in interstitial cystitis/bladder pain syndrome: associations with painful symptoms. Pain 155:1755–61
    [Google Scholar]
  131. Segerstrom SC, Boggero IA, Smith GT, Sephton SE 2014. Variability and reliability of diurnal cortisol in younger and older adults: implications for design decisions. Psychoneuroendocrinology 49:299–309
    [Google Scholar]
  132. Segerstrom SC, Miller G. 2004. Psychological stress and the human immune system: a meta-analytic study of 30 years of inquiry. Psychol. Bull. 130:601–30The most comprehensive review of the relationship between stress and the immune system.
    [Google Scholar]
  133. Segerstrom SC, O'Connor DB. 2012. Stress, health and illness: four challenges for the future. Psychol. Health 27:128–40
    [Google Scholar]
  134. Selye H. 1936. A syndrome produced by diverse nocuous agents. Nature 138:347932
    [Google Scholar]
  135. Selye H. 1950. Stress and the general adaptation syndrome. BMJ 1:1383–92
    [Google Scholar]
  136. Selye H. 1951. The general-adaptation-syndrome. Annu. Rev. Med. 2:327–42
    [Google Scholar]
  137. Slavich GM. 2019. Stressnology: the primitive (and problematic) study of life stress exposure and pressing need for better measurement. Brain Behav. Immun. 75:3–5
    [Google Scholar]
  138. Snyder-Mackler N, Sanz J, Kohn JN, Brinkworth JF, Morrow S et al. 2016. Social status alters immune regulation and response to infection in macaques. Science 354:63151041–45
    [Google Scholar]
  139. Stalder T, Kirschbaum C, Kudielka BM, Adam EK, Pruessner JC et al. 2016. Assessment of the cortisol awakening response: expert consensus guidelines. Psychoneuroendocrinology 63:414–32
    [Google Scholar]
  140. Stalder T, Steudte-Schmiedgen S, Alexander N, Klucken T, Vater A et al. 2017. Stress-related and basic determinants of hair cortisol in humans: a meta-analysis. Psychoneuroendocrinology 77:261–74
    [Google Scholar]
  141. Steptoe A, Hamer M, Lin J, Blackburn EH, Erusalimsky JD 2017. The longitudinal relationship between cortisol responses to mental stress and leukocyte telomere attrition. J. Clin. Endocrinol. Metab. 102:962–69
    [Google Scholar]
  142. Steptoe A, Serwinski B. 2016. Cortisol awakening response. Stress: Concepts, Cognition, Emotion, and Behavior G Fink 277–83 London: Academic
    [Google Scholar]
  143. Sterling P, Eyer J. 1988. Allostasis: a new paradigm to explain arousal pathology. Handbook of Life Stress, Cognition and Health S Fisher, J Reason 629–49 New York: Wiley
    [Google Scholar]
  144. Thayer JF, Lane RD. 2007. The role of vagal function in the risk for cardiovascular disease and mortality. Biol. Psychol. 74:224–42
    [Google Scholar]
  145. Thayer JF, Yamamoto SS, Brosschot JF 2010. The relationship of autonomic imbalance, heart rate variability and cardiovascular disease risk factors. Int. J. Cardiol. 141:122–31Key review linking autonomic nervous system imbalance to health outcomes.
    [Google Scholar]
  146. Thorn L, Hucklebridge F, Evans P, Clow A 2006. Suspected nonadherence and weekend versus week day differences in the awakening cortisol response. Psychoneuroendocrinology 31:1009–18
    [Google Scholar]
  147. Thrasher TN. 2006. Arterial baroreceptor input contributes to long-term control of blood pressure. Curr. Hypertens. Rep. 8:249–54
    [Google Scholar]
  148. Tomfohr L, Cooper DC, Mills PJ, Nelesen RA, Dimsdale JE 2010. Everyday discrimination and nocturnal blood pressure dipping in black and white Americans. Psychosom. Med. 72:266
    [Google Scholar]
  149. Tomiyama AJ. 2019. Stress and obesity. Annu. Rev. Psychol. 70:703–18
    [Google Scholar]
  150. Turner-Cobb JM, Rixon L, Jessop DS 2011. Hypothalamic-pituitary-adrenal axis activity and upper respiratory tract infection in young children transitioning to primary school. Psychopharmacology 214:309–17
    [Google Scholar]
  151. UK Health Saf. Executive 2019. Work Related Stress, Anxiety and Depression Statistics in Great Britain 2019 London: Crown
    [Google Scholar]
  152. Vedhara K, Ayling K, Sunger K, Caldwell D, Halliday V et al. 2019. Psychological interventions as vaccine adjuvants: a systematic review. Vaccine 37:3255–66
    [Google Scholar]
  153. Vedhara K, Cox NK, Wilcock GK, Perks P, Hunt M et al. 1999a. Chronic stress in elderly carers of dementia patients and antibody response to influenza vaccination. Lancet 353:627–31
    [Google Scholar]
  154. Vedhara K, Fox J, Wang E 1999b. The measurement of stress-related immune dysfunction in psychoneuroimmunology. Neurosci. Biobehav. Rev. 23:699–715
    [Google Scholar]
  155. Vedhara K, Tuinstra J, Miles JNV, Sanderman R, Ranchor AV 2006. Psychosocial factors associated with indices of cortisol production in women with breast cancer and controls. Psychoneuroendocrinology 31:299–311
    [Google Scholar]
  156. Waehrer GM, Miller TR, Silverio Marques SC, Oh DL, Burke Harris N 2020. Disease burden of adverse childhood experiences across 14 states. PLOS ONE 15:e0226134
    [Google Scholar]
  157. Wright KD, Hickman R, Laudenslager ML 2015. Hair cortisol analysis: a promising biomarker of HPA activation in older adults. Gerontologist 55:S140–45
    [Google Scholar]
  158. Wust S, Federenko I, Hellhammer DH, Kirschbaum C 2000. Genetic factors, perceived chronic stress and the free cortisol response to awakening. Psychoneuroendocrinology 25:707–20
    [Google Scholar]
  159. Zorn JV, Schur RR, Boks MP, Kahn RS, Joels M, Vinkers CH 2017. Cortisol stress reactivity across psychiatric disorders: a systematic review and meta-analysis. Psychoneuroendocrinology 77:25–36
    [Google Scholar]
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