Although aging is associated with clear declines in physical and cognitive processes, emotional functioning fares relatively well. Consistent with this behavioral profile, two core emotional brain regions, the amygdala and ventromedial prefrontal cortex, show little structural and functional decline in aging, compared with other regions. However, emotional processes depend on interacting systems of neurotransmitters and brain regions that go beyond these structures. This review examines how age-related brain changes influence processes such as attending to and remembering emotional stimuli, regulating emotion, and recognizing emotional expressions, as well as empathy, risk taking, impulsivity, behavior change, and attentional focus.


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Literature Cited

  1. Allard ES, Kensinger EA. 2014. Age-related differences in neural recruitment during the use of cognitive reappraisal and selective attention as emotion regulation strategies. Front. Psychol. 5:296 [Google Scholar]
  2. Allen JS, Bruss J, Brown CK, Damasio H. 2005a. Methods for studying the aging brain: volumetric analyses versus VBM. Neurobiol. Aging 26:1275–78 [Google Scholar]
  3. Allen JS, Bruss J, Brown CK, Damasio H. 2005b. Normal neuroanatomical variation due to age: the major lobes and a parcellation of the temporal region. Neurobiol. Aging 26:1245–60 [Google Scholar]
  4. Ashley V, Swick D. 2009. Consequences of emotional stimuli: age differences on pure and mixed blocks of the emotional Stroop. Behav. Brain Funct. 5:14 [Google Scholar]
  5. Aston-Jones G, Cohen JD. 2005. An integrative theory of locus coeruleus-norepinephrine function: adaptive gain and optimal performance. Annu. Rev. Neurosci. 28:403–50 [Google Scholar]
  6. Bäckman L, Lindenberger U, Li SC, Nyberg L. 2010. Linking cognitive aging to alterations in dopamine neurotransmitter functioning: recent data and future avenues. Neurosci. Biobehav. Rev. 34:670–77 [Google Scholar]
  7. Baena E, Allen PA, Kaut KP, Hall RJ. 2010. On age differences in prefrontal function: the importance of emotional/cognitive integration. Neuropsychologia 48:319–33 [Google Scholar]
  8. Bailey PE, Henry JD, Von Hippel W. 2008. Empathy and social functioning in late adulthood. Aging Ment. Health 12:499–503 [Google Scholar]
  9. Beadle JN, Paradiso S, Kovach C, Polgreen L, Denburg NL, Tranel D. 2012. Effects of age-related differences in empathy on social economic decision-making. Int. Psychogeriatr. 24:822–33 [Google Scholar]
  10. Bechara A, Tranel D, Damasio H, Damasio AR. 1996. Failure to respond autonomically to anticipated future outcomes following damage to prefrontal cortex. Cereb. Cortex 6:215–25 [Google Scholar]
  11. Beekman AT, Bremmer MA, Deeg DJ, Van Balkom AJ, Smit JH. et al. 1998. Anxiety disorders in later life: a report from the Longitudinal Aging Study Amsterdam. Int. J. Geriatr. Psychiatry 13:717–26 [Google Scholar]
  12. Berlin H, Rolls E, Kischka U. 2004. Impulsivity, time perception, emotion and reinforcement sensitivity in patients with orbitofrontal cortex lesions. Brain 127:1108–26 [Google Scholar]
  13. Bernhardt BC, Singer T. 2012. The neural basis of empathy. Annu. Rev. Neurosci. 35:1–23 [Google Scholar]
  14. Bickart KC, Wright CI, Dautoff RJ, Dickerson BC, Barrett LF. 2011. Amygdala volume and social network size in humans. Nat. Neurosci. 14:163–64 [Google Scholar]
  15. Birditt KS, Fingerman KL. 2005. Do we get better at picking our battles? Age group differences in descriptions of behavioral reactions to interpersonal tensions. J. Gerontol. Ser. B Psychol. Sci. Soc. Sci. 60:P121–28 [Google Scholar]
  16. Braak H, Thal DR, Ghebremedhin E, Del Tredici K. 2011. Stages of the pathologic process in Alzheimer disease: age categories from 1 to 100 years. J. Neuropathol. Exp. Neurol. 70:960–69 [Google Scholar]
  17. Brabec J, Rulseh A, Hoyt B, Vizek M, Horinek D. et al. 2010. Volumetry of the human amygdala—an anatomical study. Psychiatry Res. Neuroimaging 182:67–72 [Google Scholar]
  18. Brassen S, Gamer M, Buchel C. 2011. Anterior cingulate activation is related to a positivity bias and emotional stability in successful aging. Biol. Psychiatry 70:131–37 [Google Scholar]
  19. Braver TS, Krug MK, Chiew KS, Kool W, Westbrook JA. et al. 2014. Mechanisms of motivation—cognition interaction: challenges and opportunities. Cogn. Affect. Behav. Neurosci. 14:443–72 [Google Scholar]
  20. Buelow MT, Suhr JA. 2009. Construct validity of the Iowa gambling task. Neuropsychol. Rev. 19:102–14 [Google Scholar]
  21. Buhle JT, Silvers JA, Wager TD, Lopez R, Onyemekwu C. et al. 2013. Cognitive reappraisal of emotion: a meta-analysis of human neuroimaging studies. Cereb. Cortex 24:112981–90 [Google Scholar]
  22. Burzynska AZ, Preuschhof C, Bäckman L, Nyberg L, Li S-C. et al. 2010. Age-related differences in white matter microstructure: region-specific patterns of diffusivity. NeuroImage 49:2104–12 [Google Scholar]
  23. Bzdok D, Schilbach L, Vogeley K, Schneider K, Laird AR. et al. 2012. Parsing the neural correlates of moral cognition: ALE meta-analysis on morality, theory of mind, and empathy. Brain Struct. Funct. 217:783–96 [Google Scholar]
  24. Cacioppo JT, Berntson CG, Bechara A, Tranel D, Hawkley LC. 2011. Could an aging brain contribute to subjective well-being? The value added by a social neuroscience perspective. Social Neuroscience: Toward Understanding the Underpinnings of the Social Mind A Todorov, ST Fiske, D Prentice 249–62 New York: Oxford Univ. Press [Google Scholar]
  25. Calder AJ, Young AW, Keane J, Dean M. 2000. Configural information in facial expression perception. J. Exp. Psychol.: Hum. Percept. Perform. 26:527–51 [Google Scholar]
  26. Carstensen LL, Mikels JA, Mather M. 2006. Aging and the intersection of cognition, motivation and emotion. Handbook of the Psychology of Aging JE Birren, KW Schaie 343–62 San Diego, CA: Academic, 6th ed.. [Google Scholar]
  27. Carstensen LL, Turan B, Scheibe S, Ram N, Ersner-Hershfield H. et al. 2011. Emotional experience improves with age: evidence based on over 10 years of experience sampling. Psychol. Aging 26:21–33 [Google Scholar]
  28. Castelli I, Baglio F, Blasi V, Alberoni M, Falini A. et al. 2010. Effects of aging on mindreading ability through the eyes: an fMRI study. Neuropsychologia 48:2586–94 [Google Scholar]
  29. Chaby L, Narme P, George N. 2011. Older adults' configural processing of faces: role of second-order information. Psychol. Aging 26:71–79 [Google Scholar]
  30. Charles ST, Carstensen LL. 2008. Unpleasant situations elicit different emotional responses in younger and older adults. Psychol. Aging 23:495–504 [Google Scholar]
  31. Charles ST, Mather M, Carstensen LL. 2003. Aging and emotional memory: the forgettable nature of negative images for older adults. J. Exp. Psychol.: Gen. 132:310–24 [Google Scholar]
  32. Charles ST, Reynolds CA, Gatz M. 2001. Age-related differences and change in positive and negative affect over 23 years. J. Personal. Soc. Psychol. 80:136–51 [Google Scholar]
  33. Chen Y-C, Chen C-C, Decety J, Cheng Y. 2014. Aging is associated with changes in the neural circuits underlying empathy. Neurobiol. Aging 35:827–36 [Google Scholar]
  34. Cherbuin N, Sachdev PS, Anstey KJ. 2011. Mixed handedness is associated with greater age-related decline in volumes of the hippocampus and amygdala: the PATH through life study. Brain Behav. 1:125–34 [Google Scholar]
  35. Chopik WJ, Edelstein RS, Fraley RC. 2013. From the cradle to the grave: age differences in attachment from early adulthood to old age. J. Personal. 81:171–83 [Google Scholar]
  36. Chowdhury R, Guitart-Masip M, Lambert C, Dayan P, Huys Q. et al. 2013. Dopamine restores reward prediction errors in old age. Nat. Neurosci. 16:648–53 [Google Scholar]
  37. Circelli KS, Clark US, Cronin-Golomb A. 2013. Visual scanning patterns and executive function in relation to facial emotion recognition in aging. Aging Neuropsychol. Cogn. 20:148–73 [Google Scholar]
  38. Clark L, Bechara A, Damasio H, Aitken MRF, Sahakian BJ, Robbins TW. 2008. Differential effects of insular and ventromedial prefrontal cortex lesions on risky decision-making. Brain 131:1311–22 [Google Scholar]
  39. Clewett D, Bachman S, Mather M. 2014. Age-related reduced prefrontal-amygdala structural connectivity is associated with lower trait anxiety. Neuropsychology 28:631–42 [Google Scholar]
  40. Clewett D, Lee TH, Greening S, Ponzio A, Margalit E, Mather M. 2015. Neuromelanin marks the spot: identifying a locus coeruleus biomarker of cognitive reserve in healthy aging.. Neurobiol. Aging. In press
  41. Colzato LS, Van Den Wildenberg WP, Hommel B. 2013. The genetic impact (C957T-DRD2) on inhibitory control is magnified by aging. Neuropsychologia 51:1377–81 [Google Scholar]
  42. Curiati P, Tamashiro J, Squarzoni P, Duran F, Santos L. et al. 2009. Brain structural variability due to aging and gender in cognitively healthy elders: results from the São Paulo Ageing and Health Study. Am. J. Neuroradiol. 30:1850–56 [Google Scholar]
  43. Damasio AR, Tranel D, Damasio H. 1990. Individuals with sociopathic behavior caused by frontal damage fail to respond autonomically to social stimuli. Behav. Brain Res. 41:81–94 [Google Scholar]
  44. Davis SW, Dennis NA, Buchler NG, White LE. 2009. Assessing the effects of age on long white matter tracts using diffusion tensor tractography. NeuroImage 46:530–41 [Google Scholar]
  45. Demeyer I, De Raedt R. 2013. Attentional bias for emotional information in older adults: the role of emotion and future time perspective. PLOS ONE 8:e65429 [Google Scholar]
  46. Denburg NL, Recknor EC, Bechara A, Tranel D. 2006. Psychophysiological anticipation of positive outcomes promotes advantageous decision-making in normal older persons. Int. J. Psychophysiol. 61:19–25 [Google Scholar]
  47. Denburg NL, Tranel D, Bechara A. 2005. The ability to decide advantageously declines prematurely in some normal older persons. Neuropsychologia 43:1099–106 [Google Scholar]
  48. Dennis NA, Hayes SM, Prince SE, Madden DJ, Huettel SA, Cabeza R. 2008. Effects of aging on the neural correlates of successful item and source memory encoding. J. Exp. Psychol.: Learn. Mem. Cogn. 34:791–808 [Google Scholar]
  49. Diehl M, Coyle N, Labouvie-Vief G. 1996. Age and sex differences in strategies of coping and defense across the life span. Psychol. Aging 11:127–39 [Google Scholar]
  50. Dolcos S, Katsumi Y, Dixon RA. 2014. The role of arousal in the spontaneous regulation of emotions in healthy aging: a fMRI investigation. Front. Psychol. 5:681 [Google Scholar]
  51. Drobetz R, Hänggi J, Maercker A, Kaufmann K, Jäncke L, Forstmeier S. 2014. Structural brain correlates of delay of gratification in the elderly. Behav. Neurosci. 128:134–45 [Google Scholar]
  52. Eppinger B, Herbert M, Kray J. 2010. We remember the good things: age differences in learning and memory. Neurobiol. Learn. Mem. 93:515–21 [Google Scholar]
  53. Eppinger B, Nystrom LE, Cohen JD. 2012. Reduced sensitivity to immediate reward during decision-making in older than younger adults. PLOS ONE 7:e36953 [Google Scholar]
  54. Eppinger B, Schuck NW, Nystrom LE, Cohen JD. 2013. Reduced striatal responses to reward prediction errors in older compared with younger adults. J. Neurosci. 33:9905–12 [Google Scholar]
  55. Erk S, Walter H, Abler B. 2008. Age-related physiological responses to emotion anticipation and exposure. NeuroReport 19:447–52 [Google Scholar]
  56. Eysenck SB, Pearson PR, Easting G, Allsopp JF. 1985. Age norms for impulsiveness, venturesomeness and empathy in adults. Personal. Individ. Differ. 6:613–19 [Google Scholar]
  57. Fellows LK, Farah MJ. 2005a. Different underlying impairments in decision-making following ventromedial and dorsolateral frontal lobe damage in humans. Cereb. Cortex 15:58–63 [Google Scholar]
  58. Fellows LK, Farah MJ. 2005b. Dissociable elements of human foresight: a role for the ventromedial frontal lobes in framing the future, but not in discounting future rewards. Neuropsychologia 43:1214–21 [Google Scholar]
  59. Firestone A, Turk-Browne NB, Ryan JD. 2007. Age-related deficits in face recognition are related to underlying changes in scanning behavior. Aging Neuropsychol. Cogn. 14:594–607 [Google Scholar]
  60. Fischer H, Nyberg L, Backman L. 2010. Age-related differences in brain regions supporting successful encoding of emotional faces. Cortex 46:490–97 [Google Scholar]
  61. Fjell AM, McEvoy L, Holland D, Dale AM, Walhovd KB. 2013a. Brain changes in older adults at very low risk for Alzheimer's disease. J. Neurosci. 33:8237–42 [Google Scholar]
  62. Fjell AM, Walhovd KB. 2010. Structural brain changes in aging: courses, causes and cognitive consequences. Rev. Neurosci. 21:187–221 [Google Scholar]
  63. Fjell AM, Walhovd KB, Fennema-Notestine C, McEvoy LK, Hagler DJ. et al. 2009a. One-year brain atrophy evident in healthy aging. J. Neurosci. 29:15223–31 [Google Scholar]
  64. Fjell AM, Westlye LT, Amlien I, Espeseth T, Reinvang I. et al. 2009b. High consistency of regional cortical thinning in aging across multiple samples. Cereb. Cortex 19:2001–12 [Google Scholar]
  65. Fjell AM, Westlye LT, Grydeland H, Amlien I, Espeseth T. et al. 2013b. Critical ages in the life course of the adult brain: nonlinear subcortical aging. Neurobiol. Aging 34:2239–47 [Google Scholar]
  66. Ford JH, Kensinger EA. 2014. The relation between structural and functional connectivity depends on age and on task goals. Front. Hum. Neurosci. 8:307 [Google Scholar]
  67. Foster SM, Davis HP, Kisley MA. 2013. Brain responses to emotional images related to cognitive ability in older adults. Psychol. Aging 28:179–90 [Google Scholar]
  68. Frijda NH, Parrott WG. 2011. Basic emotions or ur-emotions?. Emot. Rev. 3:406–15 [Google Scholar]
  69. Frodl T, Jäger M, Smajstrlova I, Born C, Bottlender R. et al. 2008. Effect of hippocampal and amygdala volumes on clinical outcomes in major depression: a 3-year prospective magnetic resonance imaging study. J. Psychiatry Neurosci. 33:423–30 [Google Scholar]
  70. Gagliese L. 2009. Pain and aging: the emergence of a new subfield of pain research. J. Pain 10:343–53 [Google Scholar]
  71. Ge R, Fu Y, Wang D, Yao L, Long Z. 2014. Age-related alterations of brain network underlying the retrieval of emotional autobiographical memories: an fMRI study using independent component analysis. Front. Hum. Neurosci. 8:629 [Google Scholar]
  72. German TP, Hehman JA. 2006. Representational and executive selection resources in “theory of mind”: evidence from compromised belief-desire reasoning in old age. Cognition 101:129–52 [Google Scholar]
  73. Germine LT, Duchaine B, Nakayama K. 2011. Where cognitive development and aging meet: face learning ability peaks after age 30. Cognition 118:201–10 [Google Scholar]
  74. Goh JO, Suzuki A, Park DC. 2010. Reduced neural selectivity increases fMRI adaptation with age during face discrimination. NeuroImage 51:336–44 [Google Scholar]
  75. Good CD, Johnsrude IS, Ashburner J, Henson RNA, Friston KJ, Frackowiak RSJ. 2001. A voxel-based morphometric study of ageing in 465 normal adult human brains. NeuroImage 14:21–36 [Google Scholar]
  76. Grady CL, McIntosh AR, Horwitz B, Rapoport SI. 2000. Age-related changes in the neural correlates of degraded and nondegraded face processing. Cogn. Neuropsychol. 17:165–86 [Google Scholar]
  77. Grafman J, Schwab K, Warden D, Pridgen A, Brown H, Salazar A. 1996. Frontal lobe injuries, violence, and aggression: a report of the Vietnam Head Injury Study. Neurology 46:1231–38 [Google Scholar]
  78. Green L, Fry AF, Myerson J. 1994. Discounting of delayed rewards: a life-span comparison. Psychol. Sci. 5:33–36 [Google Scholar]
  79. Green L, Myerson J, Lichtman D, Rosen S, Fry A. 1996. Temporal discounting in choice between delayed rewards: the role of age and income. Psychol. Aging 11:79–84 [Google Scholar]
  80. Greenwood PM, Parasuraman R, Haxby JV. 1993. Changes in visuospatial attention over the adult lifespan. Neuropsychologia 31:471–85 [Google Scholar]
  81. Grieve SM, Clark CR, Williams LM, Peduto AJ, Gordon E. 2005. Preservation of limbic and paralimbic structures in aging. Hum. Brain Mapp. 25:391–401 [Google Scholar]
  82. Gruenewald TL, Mroczek DK, Ryff CD, Singer BH. 2008. Diverse pathways to positive and negative affect in adulthood and later life: an integrative approach using recursive partitioning. Dev. Psychol. 44:330–43 [Google Scholar]
  83. Grühn D, Rebucal K, Diehl M, Lumley M, Labouvie-Vief G. 2008. Empathy across the adult lifespan: longitudinal and experience-sampling findings. Emotion 8:753–65 [Google Scholar]
  84. Hahn S, Carlson C, Singer S, Gronlund SD. 2006. Aging and visual search: automatic and controlled attentional bias to threat faces. Acta Psychol. 123:312–36 [Google Scholar]
  85. Han SD, Boyle PA, Yu L, Fleischman DA, Arfanakis K, Bennett DA. 2013. Ventromedial PFC, parahippocampal, and cerebellar connectivity are associated with temporal discounting in old age. Exp. Gerontol. 48:1489–98 [Google Scholar]
  86. Happé FG, Winner E, Brownell H. 1998. The getting of wisdom: theory of mind in old age. Dev. Psychol. 34:358–62 [Google Scholar]
  87. Harlé KM, Sanfey AG. 2012. Social economic decision-making across the lifespan: an fMRI investigation. Neuropsychologia 50:1416–24 [Google Scholar]
  88. He X, Qin W, Liu Y, Zhang X, Duan Y. et al. 2014. Abnormal salience network in normal aging and in amnestic mild cognitive impairment and Alzheimer's disease. Hum. Brain Mapp. 35:3446–64 [Google Scholar]
  89. Heisz JJ, Ryan JD. 2011. The effects of prior exposure on face processing in younger and older adults. Front. Aging Neurosci. 3:15 [Google Scholar]
  90. Hess TM. 2005. Memory and aging in context. Psychol. Bull. 131:383–406 [Google Scholar]
  91. Hölzel BK, Carmody J, Evans KC, Hoge EA, Dusek JA. et al. 2009. Stress reduction correlates with structural changes in the amygdala. Soc. Cogn. Affect. Neurosci. 5:11–17 [Google Scholar]
  92. Isaacowitz DM, Allard ES, Murphy NA, Schlangel M. 2009a. The time course of age-related preferences toward positive and negative stimuli. J. Gerontol. Ser. B Psychol. Sci. Soc. Sci. 64:188–92 [Google Scholar]
  93. Isaacowitz DM, Toner K, Neupert SD. 2009b. Use of gaze for real-time mood regulation: effects of age and attentional functioning. Psychol. Aging 24:989–94 [Google Scholar]
  94. Isella V, Mapelli C, Morielli N, Pelati O, Franceschi M, Appollonio IM. 2008. Age-related quantitative and qualitative changes in decision making ability. Behav. Neurol. 19:59–63 [Google Scholar]
  95. Jernigan TL, Archibald SL, Fennema-Notestine C, Gamst AC, Stout JC. et al. 2001. Effects of age on tissues and regions of the cerebrum and cerebellum. Neurobiol. Aging 22:581–94 [Google Scholar]
  96. Jiang J, Sachdev P, Lipnicki DM, Zhang H, Liu T. et al. 2014. A longitudinal study of brain atrophy over two years in community-dwelling older individuals. NeuroImage 86:203–11 [Google Scholar]
  97. Kalpouzos G, Chételat G, Baron J-C, Landeau B, Mevel K. et al. 2009. Voxel-based mapping of brain gray matter volume and glucose metabolism profiles in normal aging. Neurobiol. Aging 30:112–24 [Google Scholar]
  98. Kehoe EG, Toomey JM, Balsters JH, Bokde AL. 2013. Healthy aging is associated with increased neural processing of positive valence but attenuated processing of emotional arousal: an fMRI study. Neurobiol. Aging 34:809–21 [Google Scholar]
  99. Keightley ML, Chiew KS, Winocur G, Grady CL. 2007. Age-related differences in brain activity underlying identification of emotional expressions in faces. Soc. Cogn. Affect. Neurosci. 2:292–302 [Google Scholar]
  100. Kellough JL, Knight BG. 2012. Positivity effects in older adults' perception of facial emotion: the role of future time perspective. J. Gerontol. Ser. B Psychol. Sci. Soc. Sci. 67:150–58 [Google Scholar]
  101. Kensinger EA. 2008. Age differences in memory for arousing and nonarousing emotional words. J. Gerontol. Ser. B Psychol. Sci. Soc. Sci. 63:P13–18 [Google Scholar]
  102. Khanjani Z, Mosanezhad JE, Hekmati I, Khalilzade S, Etemadi NM. et al. 2015. Comparison of cognitive empathy, emotional empathy, and social functioning in different age groups. Aust. Psychol. 50:80–85 [Google Scholar]
  103. Knight M, Seymour TL, Gaunt JT, Baker C, Nesmith K, Mather M. 2007. Aging and goal-directed emotional attention: Distraction reverses emotional biases. Emotion 7:705–14 [Google Scholar]
  104. Kryla-Lighthall N, Mather M. 2009. The role of cognitive control in older adults' emotional well-being. Handbook of Theories of Aging V Berngtson, D Gans, N Putney, M Silverstein 323–44 New York: Springer, 2nd ed.. [Google Scholar]
  105. LaBar KS, Mesulam MM, Gitelman DR, Weintraub S. 2000. Emotional curiosity: Modulation of visuospatial attention by arousal is preserved in aging and early-stage Alzheimer's disease. Neuropsychologia 38:1734–40 [Google Scholar]
  106. Lamar M, Resnick SM. 2004. Aging and prefrontal functions: dissociating orbitofrontal and dorsolateral abilities. Neurobiol. Aging 25:553–58 [Google Scholar]
  107. Lambrecht L, Kreifelts B, Wildgruber D. 2012. Age-related decrease in recognition of emotional facial and prosodic expressions. Emotion 12:529–39 [Google Scholar]
  108. Leclerc CM, Kensinger EA. 2008a. Age-related differences in medial prefrontal activation in response to emotional images. Cogn. Affect. Behav. Neurosci. 8:153–64 [Google Scholar]
  109. Leclerc CM, Kensinger EA. 2008b. Effects of age on detection of emotional information. Psychol. Aging 23:209–15 [Google Scholar]
  110. Leclerc CM, Kensinger EA. 2010. Age-related valence-based reversal in recruitment of medial prefrontal cortex on a visual search task. Soc. Neurosci. 5:560–76 [Google Scholar]
  111. Leclerc CM, Kensinger EA. 2011. Neural processing of emotional pictures and words: a comparison of young and older adults. Dev. Neuropsychol. 36:519–38 [Google Scholar]
  112. Lee TH, Sakaki M, Cheng R, Velasco R, Mather M. 2014. Emotional arousal amplifies the effects of biased competition in the brain. Soc. Cogn. Affect. Neurosci. 9:2067–77 [Google Scholar]
  113. Li S-C, Papenberg G, Nagel IE, Preuschhof C, Schröder J. et al. 2013. Aging magnifies the effects of dopamine transporter and D2 receptor genes on backward serial memory. Neurobiol. Aging 34:358.e1–10 [Google Scholar]
  114. Li S-C, Rieckmann A. 2014. Neuromodulation and aging: implications of aging neuronal gain control on cognition. Curr. Opin. Neurobiol. 29:148–58 [Google Scholar]
  115. Li W, Tol MJ, Li M, Miao W, Jiao Y. et al. 2014. Regional specificity of sex effects on subcortical volumes across the lifespan in healthy aging. Hum. Brain Mapp. 35:238–47 [Google Scholar]
  116. Lindquist KA, Wager TD, Kober H, Bliss-Moreau E, Barrett LF. 2012. The brain basis of emotion: a meta-analytic review. Behav. Brain Sci. 35:121–43 [Google Scholar]
  117. Löckenhoff CE, Carstensen LL. 2007. Aging, emotion, and health-related decision strategies: Motivational manipulations can reduce age differences. Psychol. Aging 22:134–46 [Google Scholar]
  118. Long X, Liao W, Jiang C, Liang D, Qiu B, Zhang L. 2012. Healthy aging: an automatic analysis of global and regional morphological alterations of human brain. Acad. Radiol. 19:785–93 [Google Scholar]
  119. Lövdén M, Schmiedek F, Kennedy KM, Rodrigue KM, Lindenberger U, Raz N. 2013. Does variability in cognitive performance correlate with frontal brain volume?. NeuroImage 64:209–15 [Google Scholar]
  120. MacPherson SE, Phillips LH, Della Sala S. 2002. Age, executive function, and social decision making: a dorsolateral prefrontal theory of cognitive aging. Psychol. Aging 17:598–609 [Google Scholar]
  121. Madden DJ. 2007. Aging and visual attention. Curr. Dir. Psychol. Sci. 16:70–74 [Google Scholar]
  122. Madden DJ, Parks EL, Davis SW, Diaz MT, Potter GG. et al. 2014. Age mediation of frontoparietal activation during visual feature search. NeuroImage 102:262–74 [Google Scholar]
  123. Maia TV, McClelland JL. 2004. A reexamination of the evidence for the somatic marker hypothesis: what participants really know in the Iowa gambling task. PNAS 101:16075–80 [Google Scholar]
  124. Martins B, Ponzio A, Velasco R, Kaplan J, Mather M. 2014. Dedifferentiation of emotion regulation strategies in the aging brain. Soc. Cogn. Affect. Neurosci. 10:840–47 [Google Scholar]
  125. Mata R, Josef AK, Samanez-Larkin GR, Hertwig R. 2011. Age differences in risky choice: a meta-analysis. Ann. N. Y. Acad. Sci. 1235:18–29 [Google Scholar]
  126. Mata R, Wilke A, Czienskowski U. 2013. Foraging across the life span: Is there a reduction in exploration with aging?. Front. Neurosci. 7:53 [Google Scholar]
  127. Mather M. 2006. A review of decision-making processes: weighing the risks and benefits of aging. When I'm 64 LL Carstensen, CR Hartel 145–73 Washington, DC: Natl. Acad. Press [Google Scholar]
  128. Mather M. 2007. Emotional arousal and memory binding: an object-based framework. Perspect. Psychol. Sci. 2:33–52 [Google Scholar]
  129. Mather M. 2012. The emotion paradox in the aging brain. Ann. N. Y. Acad. Sci. 1251:33–49 [Google Scholar]
  130. Mather M, Canli T, English T, Whitfield SL, Wais P. et al. 2004. Amygdala responses to emotionally valenced stimuli in older and younger adults. Psychol. Sci. 15:259–63 [Google Scholar]
  131. Mather M, Carstensen LL. 2003. Aging and attentional biases for emotional faces. Psychol. Sci. 14:409–15 [Google Scholar]
  132. Mather M, Carstensen LL. 2005. Aging and motivated cognition: the positivity effect in attention and memory. Trends Cogn. Sci. 9:496–502 [Google Scholar]
  133. Mather M, Clewett D, Sakaki M, Harley CW. 2015. Norepinephrine ignites local hot spots of neuronal excitation: how arousal amplifies selectivity in perception and memory. Behav. Brain Sci. In press
  134. Mather M, Johnson MK. 2000. Choice-supportive source monitoring: Do our decisions seem better to us as we age?. Psychol. Aging 15:596–606 [Google Scholar]
  135. Mather M, Knight M. 2005. Goal-directed memory: the role of cognitive control in older adults' emotional memory. Psychol. Aging 20:554–70 [Google Scholar]
  136. Mather M, Knight M, McCaffrey M. 2005. The allure of the alignable: younger and older adults' false memories of choice features. J. Exp. Psychol.: Gen. 134:38–51 [Google Scholar]
  137. Mather M, Knight MR. 2006. Angry faces get noticed quickly: Threat detection is not impaired among older adults. J. Gerontol. Ser. B Psychol. Sci. Soc. Sci. 61:P54–57 [Google Scholar]
  138. Mather M, Mazar N, Gorlick M, Lighthall NR, Ariely D. 2012. Risk preferences and aging: the “certainty effect” in older adults' decision making. Psychol. Aging 27:801–16 [Google Scholar]
  139. Mather M, Ponzio A. 2015. Emotion and aging. Handbook of Emotions LF Barrett, M Lewis, J Haviland-Jones New York: Guilford, 4th. In press [Google Scholar]
  140. Mather M, Schoeke A. 2011. Positive outcomes enhance incidental learning for both younger and older adults. Front. Neurosci. 5:129 [Google Scholar]
  141. Maylor EA, Moulson JM, Muncer AM, Taylor LA. 2002. Does performance on theory of mind tasks decline in old age?. Br. J. Psychol. 93:465–85 [Google Scholar]
  142. Meier TB, Desphande AS, Vergun S, Nair VA, Song J. et al. 2012. Support vector machine classification and characterization of age-related reorganization of functional brain networks. NeuroImage 60:601–13 [Google Scholar]
  143. Mell T, Heekeren HR, Marschner A, Wartenburger I, Villringer A, Reischies FM. 2005. Effect of aging on stimulus-reward association learning. Neuropsychologia 43:554–63 [Google Scholar]
  144. Menon V, Uddin LQ. 2010. Saliency, switching, attention and control: a network model of insula function. Brain Struct. Funct. 214:655–67 [Google Scholar]
  145. Moran JM. 2013. Lifespan development: the effects of typical aging on theory of mind. Behav. Brain Res. 237:32–40 [Google Scholar]
  146. Moran JM, Jolly E, Mitchell JP. 2012. Social-cognitive deficits in normal aging. J. Neurosci. 32:5553–61 [Google Scholar]
  147. Morey RA, Petty CM, Xu Y, Hayes JP, Wagner HR. et al. 2009. A comparison of automated segmentation and manual tracing for quantifying hippocampal and amygdala volumes. NeuroImage 45:855–66 [Google Scholar]
  148. Moriguchi Y, Negreira A, Weierich M, Dautoff R, Dickerson BC. et al. 2011. Differential hemodynamic response in affective circuitry with aging: an fMRI study of novelty, valence, and arousal. J. Cogn. Neurosci. 23:1027–41 [Google Scholar]
  149. Mouton PR, Pakkenberg B, Gundersen HJG, Price DL. 1994. Absolute number and size of pigmented locus coeruleus neurons in young and aged individuals. J. Chem. Neuroanat. 7:185–90 [Google Scholar]
  150. Mu Q, Xie J, Wen Z, Weng Y, Shuyun Z. 1999. A quantitative MR study of the hippocampal formation, the amygdala, and the temporal horn of the lateral ventricle in healthy subjects 40 to 90 years of age. Am. J. Neuroradiol. 20:207–11 [Google Scholar]
  151. Murphy NA, Isaacowitz DM. 2010. Age effects and gaze patterns in recognising emotional expressions: an in-depth look at gaze measures and covariates. Cogn. Emot. 24:436–52 [Google Scholar]
  152. Murray LJ, Ranganath C. 2007. The dorsolateral prefrontal cortex contributes to successful relational memory encoding. J. Neurosci. 27:5515–22 [Google Scholar]
  153. Nagel IE, Chicherio C, Li S-C, Von Oertzen T, Sander T. et al. 2008. Human aging magnifies genetic effects on executive functioning and working memory. Front. Hum. Neurosci. 2:1 [Google Scholar]
  154. Nashiro K, Sakaki M, Huffman D, Mather M. 2013a. Both younger and older adults have difficulty updating emotional memories. J. Gerontol. Ser. B Psychol. Sci. Soc. Sci. 68:224–27 [Google Scholar]
  155. Nashiro K, Sakaki M, Mather M. 2012a. Age differences in brain activity during emotion processing: reflections of age-related decline or increased emotion regulation?. Gerontology 58:156–63 [Google Scholar]
  156. Nashiro K, Sakaki M, Nga L, Mather M. 2012b. Differential brain activity during emotional versus non-emotional reversal learning. J. Cogn. Neurosci. 24:1794–805 [Google Scholar]
  157. Nashiro K, Sakaki M, Nga L, Mather M. 2013b. Age-related similarities and differences in brain activity underlying reversal learning. Front. Integr. Neurosci. 7:37 [Google Scholar]
  158. Nielsen L, Knutson B, Carstensen LL. 2008. Affect dynamics, affective forecasting, and aging. Emotion 8:318–30 [Google Scholar]
  159. O'Leary KD, Woodin EM. 2005. Partner aggression and problem drinking across the lifespan: How much do they decline?. Clin. Psychol. Rev. 25:877–94 [Google Scholar]
  160. Oatley K, Johnson-Laird PN. 1987. Towards a cognitive theory of emotions. Cogn. Emot. 1:29–50 [Google Scholar]
  161. Onoda K, Ishihara M, Yamaguchi S. 2012. Decreased functional connectivity by aging is associated with cognitive decline. J. Cogn. Neurosci. 24:2186–98 [Google Scholar]
  162. Opitz PC, Rauch LC, Terry DP, Urry HL. 2012. Prefrontal mediation of age differences in cognitive reappraisal. Neurobiol. Aging 33:645–55 [Google Scholar]
  163. Persson N, Ghisletta P, Dahle CL, Bender AR, Yang Y. et al. 2014. Regional brain shrinkage over two years: individual differences and effects of pro-inflammatory genetic polymorphisms. NeuroImage 103:334–48 [Google Scholar]
  164. Petrican R, Moscovitch M, Schimmack U. 2008. Cognitive resources, valence, and memory retrieval of emotional events in older adults. Psychol. Aging 23:585–94 [Google Scholar]
  165. Phillips LH, Della Sala S. 1998. Aging, intelligence, and anatomical segregation in the frontal lobes. Learn. Individ. Differ. 10:217–43 [Google Scholar]
  166. Phillips LH, Henry J, Hosie J, Milne A. 2006. Age, anger regulation and well-being. Aging Ment. Health 10:250–56 [Google Scholar]
  167. Phillips LH, MacLean RDJ, Allen R. 2002. Age and the understanding of emotions: neuropsychological and sociocognitive perspectives. J. Gerontol. Ser. B Psychol. Sci. Soc. Sci. 57:P526–30 [Google Scholar]
  168. Raz N, Ghisletta P, Rodrigue KM, Kennedy KM, Lindenberger U. 2010. Trajectories of brain aging in middle-aged and older adults: regional and individual differences. NeuroImage 51:501–11 [Google Scholar]
  169. Reed AE, Chan L, Mikels JA. 2014. Meta-analysis of the age-related positivity effect: age differences in preferences for positive over negative information. Psychol. Aging 29:1–15 [Google Scholar]
  170. Reimers S, Maylor EA, Stewart N, Chater N. 2009. Associations between a one-shot delay discounting measure and age, income, education and real-world impulsive behavior. Personal. Individ. Differ. 47:973–78 [Google Scholar]
  171. Richter D, Kunzmann U. 2011. Age differences in three facets of empathy: performance-based evidence. Psychol. Aging 26:60–70 [Google Scholar]
  172. Roesch MR, Bryden DW, Cerri DH, Haney ZR, Schoenbaum G. 2012. Willingness to wait and altered encoding of time-discounted reward in the orbitofrontal cortex with normal aging. J. Neurosci. 32:5525–33 [Google Scholar]
  173. Ruffman T, Henry JD, Livingstone V, Phillips LH. 2008. A meta-analytic review of emotion recognition and aging: implications for neuropsychological models of aging. Neurosci. Biobehav. Rev. 32:863–81 [Google Scholar]
  174. Sakaki M, Fryer K, Mather M. 2014. Emotion strengthens high-priority memory traces but weakens low-priority memory traces. Psychol. Sci. 25:387–95 [Google Scholar]
  175. Sakaki M, Nga L, Mather M. 2013. Amygdala functional connectivity with medial prefrontal cortex at rest predicts the positivity effect in older adults' memory. J. Cogn. Neurosci. 25:1206–24 [Google Scholar]
  176. Samanez-Larkin GR, Mata R, Radu PT, Ballard IC, Carstensen LL, McClure SM. 2011. Age differences in striatal delay sensitivity during intertemporal choice in healthy adults. Front. Neurosci. 5:126 [Google Scholar]
  177. Samanez-Larkin GR, Worthy DA, Mata R, McClure SM, Knutson B. 2014. Adult age differences in frontostriatal representation of prediction error but not reward outcome. Cogn. Affect. Behav. Neurosci. 14:672–82 [Google Scholar]
  178. Sasse LK, Gamer M, Büchel C, Brassen S. 2014. Selective control of attention supports the positivity effect in aging. PLOS ONE 9:e104180 [Google Scholar]
  179. Schaub R, Linden M. 2000. Anxiety and anxiety disorders in the old and very old—results from the Berlin Aging Study (BASE). Compr. Psychiatry 41:48–54 [Google Scholar]
  180. Scheibe S, Sheppes G, Staudinger UM. 2015. Distract or reappraise? Age-related differences in emotion-regulation choice. Emotion In press
  181. Schieman S, Van Gundy K. 2000. The personal and social links between age and self-reported empathy. Soc. Psychol. Q. 63:152–74 [Google Scholar]
  182. Schott BH, Niehaus L, Wittmann BC, Schutze H, Seidenbecher CI. et al. 2007. Ageing and early-stage Parkinson's disease affect separable neural mechanisms of mesolimbic reward processing. Brain 130:2412–24 [Google Scholar]
  183. Schultz W. 2013. Updating dopamine reward signals. Curr. Opin. Neurobiol. 23:229–38 [Google Scholar]
  184. Shen J, Kassir MA, Wu J, Zhang Q, Zhou S. et al. 2013. MR volumetric study of piriform-cortical amygdala and orbitofrontal cortices: the aging effect. PLOS ONE 8:e74526 [Google Scholar]
  185. Sheppes G. 2014. Emotion regulation choice: theory and findings. Handbook of Emotion Regulation JJ Gross 126–39 New York: Guilford, 2nd ed.. [Google Scholar]
  186. Silvers JA, Buhle JT, Ochsner KN, Silvers J. 2013. The neuroscience of emotion regulation: basic mechanisms and their role in development, aging, and psychopathology. Handb. Cogn. Neurosci. 1:52–78 [Google Scholar]
  187. Simon NW, Lasarge CL, Montgomery KS, Williams MT, Mendez IA. et al. 2010. Good things come to those who wait: attenuated discounting of delayed rewards in aged Fischer 344 rats. Neurobiol. Aging 31:853–62 [Google Scholar]
  188. Simón T, Suengas AG, Ruiz-Gallego-Largo T, Bandrés J. 2013. Positive bias is a defining characteristic of aging to the same extent as declining performance. Int. J. Psychol. 48:704–14 [Google Scholar]
  189. Slessor G, Phillips LH, Bull R. 2007. Exploring the specificity of age-related differences in theory of mind tasks. Psychol. Aging 22:639–43 [Google Scholar]
  190. Slessor G, Riby DM, Finnerty AN. 2013. Age-related differences in processing face configuration: the importance of the eye region. J. Gerontol. Ser. B Psychol. Sci. Soc. Sci. 68:228–31 [Google Scholar]
  191. Spaniol J, Schain C, Bowen HJ. 2014. Reward-enhanced memory in younger and older adults. J. Gerontol. Ser. B Psychol. Sci. Soc. Sci. 69:730–40 [Google Scholar]
  192. Spreng RN, Wojtowicz M, Grady CL. 2011. Reliable differences in brain activity between young and old adults: a quantitative meta-analysis across multiple cognitive domains. Neurosci. Biobehav. Rev. 34:1178–94 [Google Scholar]
  193. St. Jacques PL, Bessette-Symons B, Cabeza R. 2009. Functional neuroimaging studies of aging and emotion: fronto-amygdalar differences during emotional perception and episodic memory. J. Int. Neuropsychol. Soc. 15:819–25 [Google Scholar]
  194. St. Jacques PL, Dolcos F, Cabeza R. 2010. Effects of aging on functional connectivity of the amygdala during negative evaluation: a network analysis of fMRI data. Neurobiol. Aging 31:315–27 [Google Scholar]
  195. Stalnaker TA, Franz TM, Singh T, Schoenbaum G. 2007. Basolateral amygdala lesions abolish orbitofrontal-dependent reversal impairments. Neuron 54:51–58 [Google Scholar]
  196. Störmer VS, Passow S, Biesenack J, Li S-C. 2012. Dopaminergic and cholinergic modulations of visual-spatial attention and working memory: insights from molecular genetic research and implications for adult cognitive development. Dev. Psychol. 48:875–89 [Google Scholar]
  197. Streubel B, Kunzmann U. 2011. Age differences in emotional reactions: arousal and age-relevance count. Psychol. Aging 26:966–78 [Google Scholar]
  198. Sullivan S, Ruffman T, Hutton SB. 2007. Age differences in emotion recognition skills and the visual scanning of emotion faces. J. Gerontol. Ser. B Psychol. Sci. Soc. Sci. 62:P53–60 [Google Scholar]
  199. Sutherland MR, Mather M. 2015. Negative arousal increases stimulus priority in older adults. Exp. Aging Res. 41259–71
  200. Thomas C, Moya L, Avidan G, Humphreys K, Jung KJ. et al. 2008. Reduction in white matter connectivity, revealed by diffusion tensor imaging, may account for age-related changes in face perception. J. Cogn. Neurosci. 20:268–84 [Google Scholar]
  201. Tisserand DJ, Van Boxtel MP, Pruessner JC, Hofman P, Evans AC, Jolles J. 2004. A voxel-based morphometric study to determine individual differences in gray matter density associated with age and cognitive change over time. Cereb. Cortex 14:966–73 [Google Scholar]
  202. Tomasi D, Volkow N. 2012. Functional connectivity density and the aging brain. Mol. Psychiatry 17:471–71 [Google Scholar]
  203. Tottenham N, Hare TA, Quinn BT, McCarry TW, Nurse M. et al. 2010. Prolonged institutional rearing is associated with atypically large amygdala volume and difficulties in emotion regulation. Dev. Sci. 13:46–61 [Google Scholar]
  204. Urry HL, Van Reekum CM, Johnstone T, Kalin NH, Thurow ME. et al. 2006. Amygdala and ventromedial prefrontal cortex are inversely coupled during regulation of negative affect and predict the diurnal pattern of cortisol secretion among older adults. J. Neurosci. 26:4415–25 [Google Scholar]
  205. Vijayashankar N, Brody H. 1979. Quantitative study of the pigmented neurons in the nuclei locus coeruleus and subcoeruleus in man as related to aging. J. Neuropathol. Exp. Neurol. 38:490–97 [Google Scholar]
  206. Vink M, Kleerekooper I, Van Den Wildenberg WP, Kahn RS. 2015. Impact of aging on frontostriatal reward processing. Hum. Brain Mapp. 36:2305–17 [Google Scholar]
  207. Waldinger RJ, Kensinger EA, Schulz MS. 2011. Neural activity, neural connectivity, and the processing of emotionally valenced information in older adults: links with life satisfaction. Cogn. Affect. Behav. Neurosci. 11:426–36 [Google Scholar]
  208. Walhovd KB, Fjell AM, Reinvang I, Lundervold A, Dale AM. et al. 2005. Effects of age on volumes of cortex, white matter and subcortical structures. Neurobiol. Aging 26:1261–70 [Google Scholar]
  209. Wang LY, Murphy RR, Hanscom B, Li G, Millard SP. et al. 2013. Cerebrospinal fluid norepinephrine and cognition in subjects across the adult age span. Neurobiol. Aging 34:2287–92 [Google Scholar]
  210. West RL. 1996. An application of prefrontal cortex function theory to cognitive aging. Psychol. Bull. 120:272–92 [Google Scholar]
  211. Williams LM, Brown KJ, Palmer D, Liddell BJ, Kemp AH. et al. 2006. The mellow years? Neural basis of improving emotional stability over age. J. Neurosci. 26:6422–30 [Google Scholar]
  212. Wilson RS, Nag S, Boyle PA, Hizel LP, Yu L. et al. 2013. Neural reserve, neuronal density in the locus coeruleus, and cognitive decline. Neurology 80:1202–8 [Google Scholar]
  213. Winecoff A, Labar KS, Madden DJ, Cabeza R, Huettel SA. 2011. Cognitive and neural contributors to emotion regulation in aging. Soc. Cogn. Affect. Neurosci. 6:165–76 [Google Scholar]
  214. Winstanley CA, Theobald DE, Cardinal RN, Robbins TW. 2004. Contrasting roles of basolateral amygdala and orbitofrontal cortex in impulsive choice. J. Neurosci. 24:4718–22 [Google Scholar]
  215. Wong B, Cronin-Golomb A, Neargarder S. 2005. Patterns of visual scanning as predictors of emotion identification in normal aging. Neuropsychology 19:739–49 [Google Scholar]
  216. Wood S, Busemeyer J, Koling A, Cox CR, Davis H. 2005. Older adults as adaptive decision makers: evidence from the Iowa gambling task. Psychol. Aging 20:220–25 [Google Scholar]
  217. Worthy D, Cooper J, Byrne K, Gorlick M, Maddox WT. 2014. State-based versus reward-based motivation in younger and older adults. Cogn. Affect. Behav. Neurosci. 14:1208–20 [Google Scholar]
  218. Wright CI, Dickerson BC, Feczko E, Negeira A, Williams D. 2007. A functional magnetic resonance imaging study of amygdala responses to human faces in aging and mild Alzheimer's disease. Biol. Psychiatry 62:1388–95 [Google Scholar]
  219. Wright CI, Negreira A, Gold AL, Britton JC, Williams D, Barrett LF. 2008. Neural correlates of novelty and face-age effects in young and elderly adults. NeuroImage 42:956–68 [Google Scholar]
  220. Zamarian L, Sinz H, Bonatti E, Gamboz N, Delazer M. 2008. Normal aging affects decisions under ambiguity, but not decisions under risk. Neuropsychology 22:645–57 [Google Scholar]
  221. Zanto TP, Pan P, Liu H, Bollinger J, Nobre AC, Gazzaley A. 2011. Age-related changes in orienting attention in time. J. Neurosci. 31:12461–70 [Google Scholar]

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