1932

Abstract

Vitamin B is a complex organometallic cofactor associated with three subfamilies of enzymes: the adenosylcobalamin-dependent isomerases, the methylcobalamin-dependent methyltransferases, and the dehalogenases. Different chemical aspects of the cofactor are exploited during catalysis by the isomerases and the methyltransferases. Thus, the cobalt-carbon bond ruptures homolytically in the isomerases, whereas it is cleaved heterolytically in the methyltransferases. The reaction mechanism of the dehalogenases, the most recently discovered class of B enzymes, is poorly understood. Over the past decade our understanding of the reaction mechanisms of B enzymes has been greatly enhanced by the availability of large amounts of enzyme that have afforded detailed structure-function studies, and these recent advances are the subject of this review.

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/content/journals/10.1146/annurev.biochem.72.121801.161828
2003-07-01
2024-06-20
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/content/journals/10.1146/annurev.biochem.72.121801.161828
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  • Article Type: Review Article
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