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Annual Review of Biochemistry

Volume 73, 2004

The Excitement of Discovery

Abstract

I had the good luck to start research at the dawn of molecular biology when it was possible to ask fundamental questions about the nature of the nucleic acids and how information is transferred in living systems. The search for answers led me into many different areas, often with the question of how molecular structure leads to biological function. Early work in this period provided some of the roots supporting the current explosive developments in life sciences. Here I give a brief account of my development, describe some contributions, and provide a hint of the exhilaration in discovering new things. Most of all, I had the good fortune to have inspiring teachers, stimulating colleagues, and excellent students.

Keyword(s): Autobiography
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/content/journals/10.1146/annurev.biochem.73.011303.073945
2004-07-01
2025-04-24
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Literature Cited

  1. Edsall JT, Otvos JW, Rich A. 1950. J. Am. Chem. Soc. 72:474–77 [Google Scholar]
  2. Rich A. 1952. Proc. Natl. Acad. Sci. USA 38:187–96 [Google Scholar]
  3. Dunitz JD, Orgel LE, Rich A. 1956. Acta Crystallogr. 9:373–75 [Google Scholar]
  4. Gamow G. 1954. Nature 173:318–20 [Google Scholar]
  5. Gamow G, Rich A, Yas M. 1956. In Advances in Biological and Medical Physics, 423–68 New York: Academic [Google Scholar]
  6. Hoagland MB, Zamecnik PC, Stephenson ML. 1957. Biochim. Biophys. Acta 24:215–16 [Google Scholar]
  7. Rich A, Watson JD. 1954. Nature 173:995–96 [Google Scholar]
  8. Rich A, Watson JD. 1954. Proc. Natl. Acad. Sci. USA 40:759–64 [Google Scholar]
  9. Grunberg-Manago M, Ortiz PJ, Ochoa S. 1955. Science 122:907–10 [Google Scholar]
  10. Rich A, Davies DR, Crick FHC, Watson JD. 1961. J. Mol. Biol. 3:71–86 [Google Scholar]
  11. Crick FHC, Rich A. 1955. Nature 176:780–81 [Google Scholar]
  12. Rich A, Crick FHC. 1955. Nature 176:915–16 [Google Scholar]
  13. Rich A, Crick FHC. 1961. J. Mol. Biol. 3:483–506 [Google Scholar]
  14. Rich A, Davies DR. 1956. J. Am. Chem. Soc. 78:3548 [Google Scholar]
  15. Warner RC. 1956. Fed. Proc. 15:379 [Google Scholar]
  16. Kornberg A, Lehman IR, Bessman MJ, Simms ES. 1956. Biochim. Biophys. Acta 21:197–98 [Google Scholar]
  17. Felsenfeld G, Rich A. 1957. Biochim. Biophys. Acta 26:457–68 [Google Scholar]
  18. Felsenfeld G, Davies DR, Rich A. 1957. J. Am. Chem. Soc. 79:2023–24 [Google Scholar]
  19. Hoogsteen K. 1959. Acta Crystallogr. 12:822–23 [Google Scholar]
  20. Rich A. 1957. In The Chemical Basis of Heredity, ed. WD McElroy, B Glass 557–62 Baltimore: Johns Hopkins Univ. Press [Google Scholar]
  21. Rich A. 1958. Nature 181:521–25 [Google Scholar]
  22. Rich A. 1958. Biochim. Biophys. Acta 29:502–9 [Google Scholar]
  23. Davies DR, Rich A. 1958. J. Am. Chem. Soc. 80:1003 [Google Scholar]
  24. Tener GM, Khorana HG, Markham R, Pol EH. 1958. J. Am. Chem. Soc. 80:6223–30 [Google Scholar]
  25. Rich A. 1960. Proc. Natl. Acad. Sci. USA 46:1044–53 [Google Scholar]
  26. Furth JJ, Hurwitz J, Goldmann M. 1961. Biochem. Biophys. Res. Commun. 4:362–67 [Google Scholar]
  27. Doty P, Marmur J, Eigner J, Schildkraut C. 1960. Proc. Natl. Acad. Sci. USA 46:461–76 [Google Scholar]
  28. Marmur J, Lane D. 1960. Proc. Natl. Acad. Sci. USA 46:453–61 [Google Scholar]
  29. Hall BD, Spiegelman S. 1961. Proc. Natl. Acad. Sci. USA 47:137–46 [Google Scholar]
  30. Goodman HM, Rich A. 1962. Proc. Natl. Acad. Sci. USA 48:2101–9 [Google Scholar]
  31. Rich A. 1962. In Horizons in Biochemistry, ed. M Kasha, B Pullman 103–26 New York: Academic [Google Scholar]
  32. Chun EHL, Vaughn MH, Rich A. 1963. J. Mol. Biol. 7:130–41 [Google Scholar]
  33. Sobell HM, Tomita K, Rich A. 1963. Proc. Natl. Acad. Sci. USA 49:885–92 [Google Scholar]
  34. Pauling L, Corey RB. 1956. Arch. Biochem. Biophys. 65:164–68 [Google Scholar]
  35. Mathews FS, Rich A. 1964. J. Mol. Biol. 8:89–95 [Google Scholar]
  36. Katz L, Tomita K, Rich A. 1965. J. Mol. Biol. 13:340–50 [Google Scholar]
  37. Tomita K, Katz L, Rich A. 1967. J. Mol. Biol. 30:545–49 [Google Scholar]
  38. Voet D, Rich A. 1970. Prog. Nucleic Acid Res. Mol. Biol. 10:183–265 [Google Scholar]
  39. Kyogoku Y, Lord R, Rich A. 1966. Science 154:518–20 [Google Scholar]
  40. Arnott S, Wilkins MHF, Hamilton LD, Langridge R. 1965. J. Mol. Biol. 11:391–402 [Google Scholar]
  41. Day RO, Seeman NC, Rosenberg JM, Rich A. 1973. Proc. Natl. Acad. Sci. USA 70:849–53 [Google Scholar]
  42. Rosenberg JM, Seeman NC, Kim JJP, Suddath FL, Nicholas HB, Rich A. 1973. Nature 243:150–54 [Google Scholar]
  43. Wang AH-J, Fujii S, van Boom JH, van der Marel GA, van Boeckel SAA, Rich A. 1982. Nature 299:601–4 [Google Scholar]
  44. Crick FHC, Barnett L, Brenner S, Watts-Tobin RJ. 1961. Nature 192:1227–32 [Google Scholar]
  45. Warner JR, Rich A, Hall CE. 1962. Science 138:1399–403 [Google Scholar]
  46. Warner JR, Knopf PM, Rich A. 1963. Proc. Natl. Acad. Sci. USA 149:122–29 [Google Scholar]
  47. Goodman HM, Rich A. 1963. Nature 199:318–22 [Google Scholar]
  48. Warner JR, Rich A. 1964. J. Mol. Biol. 10:202–11 [Google Scholar]
  49. Warner JR, Rich A. 1964. Proc. Natl. Acad. Sci. USA 51:1134–41 [Google Scholar]
  50. Malkin LI, Rich A. 1967. J. Mol. Biol. 26:329–46 [Google Scholar]
  51. Ban N, Nissen P, Hansen J, Moore PB, Steitz TA. 2000. Science 289:905–20 [Google Scholar]
  52. Kiho Y, Rich A. 1964. Proc. Natl. Acad. Sci. USA 51:111–18 [Google Scholar]
  53. Fahnestock S, Neumann H, Shashoua V, Rich A. 1970. Biochemistry 9:2477–83 [Google Scholar]
  54. Fahnestock S, Rich A. 1971. Nat. New Biol. 229:8–10 [Google Scholar]
  55. Fahnestock S, Rich A. 1971. Science 173:340–43 [Google Scholar]
  56. Kim S-H, Rich A. 1968. Science 162:1381–84 [Google Scholar]
  57. Kim S-H, Rich A. 1969. Science 166:1621–24 [Google Scholar]
  58. Kim S-H, Quigley G, Suddath FL, Rich A. 1971. Proc. Natl. Acad. Sci. USA 68:841–45 [Google Scholar]
  59. Holley RW, Apgar J, Everett GA, Madison JT, Marguisse M. et al. 1965. Science 147:1462–65 [Google Scholar]
  60. Conn JF, Kim JJ, Suddath FL, Blattman P, Rich A. 1974. J. Am. Chem. Soc. 96:7152–53 [Google Scholar]
  61. Kim S-H, Quigley GJ, Suddath FL, McPherson A, Sneden D. et al. 1973. Science 179:285–88 [Google Scholar]
  62. Rich A. 1974. In Ribosomes, ed. M Nomura, A Tissiere, P Lengyel 871–84 Cold Spring Harbor, NY: Cold Spring Harbor Lab. Press [Google Scholar]
  63. Yusupova GZ, Yusupova MM, Cate JHD, Noller HF. 2001. Cell 106:233–41 [Google Scholar]
  64. Kim S-H, Suddath FL, Quigley GJ, McPherson A, Sussman JL. et al. 1974. Science 185:435–39 [Google Scholar]
  65. Robertus JD, Ladner JE, Finch JT, Rhodes D, Brown RS. et al. 1974. Nature 250:546–51 [Google Scholar]
  66. Kim S-H, Sussman JL, Suddath FL, Quigley GJ, McPherson A. et al. 1974. Proc. Natl. Acad. Sci. USA 71:4970–74 [Google Scholar]
  67. Quigley GJ, Wang AH-J, Seeman NC, Suddath FL, Rich A. et al. 1975. Proc. Natl. Acad. Sci. USA 72:4866–70 [Google Scholar]
  68. Quigley GJ, Rich A. 1976. Science 194:796–806 [Google Scholar]
  69. Klein HP, Horowitz NH, Levin GV, Oyama VI, Lederberg J. et al. 1976. Science 194:99–105 [Google Scholar]
  70. Wang AH-J, Quigley GJ, Kolpak FJ, Crawford JL, van Boom JH. et al. 1979. Nature 282:680–86 [Google Scholar]
  71. Pohl FM, Jovin TM. 1972. J. Mol. Biol. 67:375–96 [Google Scholar]
  72. Thamann TJ, Lord RC, Wang AH-J, Rich A. 1981. Nucleic Acids Res. 9:5443–57 [Google Scholar]
  73. Rich A, Nordheim A, Wang AH-J. 1984. Rev. Biochem. 53:791–846 [Google Scholar]
  74. Nordheim A, Rich A. 1983. Proc. Natl. Acad. Sci. USA 80:1821–25 [Google Scholar]
  75. Feigon J, Wang AH-J, van der Marel GA, van Boom JH, Rich A. 1985. Science 230:82–84 [Google Scholar]
  76. Peck LJ, Nordheim A, Rich A, Wang JC. 1982. Proc. Natl. Acad. Sci. USA 79:4560–64 [Google Scholar]
  77. Lafer EM, Moller A, Nordheim A, Stollar BD, Rich A. 1981. Proc. Nat. Acad. Sci. USA 78:3546–50 [Google Scholar]
  78. Moller A, Gabriels JE, Lafer EM, Nordheim A, Rich A, Stollar BD. 1982. J. Biol. Chem. 257:12081–85 [Google Scholar]
  79. Lafer EM, Valle RPC, Moller A, Nordheim A, Schur P. et al. 1983. J. Clin. Invest. 71:314–21 [Google Scholar]
  80. Nordheim A, Pardue ML, Lafer EM, Moller A, Stollar BD, Rich A. 1981. Nature 294:417–22 [Google Scholar]
  81. Lipps HJ, Nordheim A, Lafer EM, Ammermann D, Stollar BD, Rich A. 1983. Cell 32:435–41 [Google Scholar]
  82. Liu LF, Wang JC. 1987. Proc. Natl. Acad. Sci. USA 84:7024–27 [Google Scholar]
  83. Schroth GP, Chou P-J, Ho PS. 1992. J. Biol. Chem. 267:11846–55 [Google Scholar]
  84. Jackson DA, Yuan J, Cook PR. 1988. J. Cell. Sci. 90:365–78 [Google Scholar]
  85. Wittig B, Dorbic T, Rich A. 1989. J. Cell. Biol. 108:755–64 [Google Scholar]
  86. Wittig B, Dorbic T, Rich A. 1991. Proc. Natl. Acad. Sci. USA 88:2259–63 [Google Scholar]
  87. Wittig B, Wolfl T, Dorbic T, Vahrson W, Rich A. 1992. EMBO J. 11:4653–63 [Google Scholar]
  88. Herbert AG, Rich A. 1993. Nucleic Acids Res. 21:2669–72 [Google Scholar]
  89. Herbert A, Lowenhaupt K, Spitzner J, Rich A. 1995. Proc. Natl. Acad. Sci. USA 92:7550–54 [Google Scholar]
  90. Bass BL. 2002. Annu. Rev. Biochem. 71:817–46 [Google Scholar]
  91. Herbert A, Alfken J, Kim Y-G, Mian IS, Nishikura K, Rich A. 1997. Proc. Natl. Acad. Sci. USA 94:8421–26 [Google Scholar]
  92. Kim Y-G, Kim PS, Herbert A, Rich A. 1997. Proc. Natl. Acad. Sci. USA 94:12875–79 [Google Scholar]
  93. Schwartz T, Rould MA, Lowenhaupt K, Herbert A, Rich A. 1999. Science 284:1841–45 [Google Scholar]
  94. Herbert A, Rich A. 2001. Proc. Natl. Acad. Sci. USA 98:12132–37 [Google Scholar]
  95. Brown BA, Lowenhaupt K, Wilbert CM, Hanlon EB, Rich A. 2000. Proc. Natl. Acad. Sci. USA 97:13532–36 [Google Scholar]
  96. Schwartz T, Behlke J, Lowenhaupt K, Heinemann U, Rich A. 2001. Nat. Struct. Biol. 8:761–65 [Google Scholar]
  97. Brandt TA, Jacobs BL. 2001. J. Virol. 75:850–56 [Google Scholar]
  98. Kim Y-G, Muralinath M, Brandt T, Pearcy M, Hauns K. et al. 2003. Proc. Natl. Acad. Sci. USA 100:6974–79 [Google Scholar]
/content/journals/10.1146/annurev.biochem.73.011303.073945
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The Excitement of Discovery
Annual Review of Biochemistry 73, 1 (2004); https://doi.org/10.1146/annurev.biochem.73.011303.073945
/content/journals/10.1146/annurev.biochem.73.011303.073945
/content/journals/10.1146/annurev.biochem.73.011303.073945
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