1932

Abstract

The signal recognition particle (SRP) directs integral membrane and secretory proteins to the cellular protein translocation machinery during translation. The SRP is an evolutionarily conserved RNA-protein complex whose activities are regulated by GTP hydrolysis. Recent structural investigations of SRP functional domains and interactions provide new insights into the mechanisms of SRP activity in all cells, leading toward a comprehensive understanding of protein trafficking by this elegant pathway.

Loading

Article metrics loading...

/content/journals/10.1146/annurev.biochem.73.011303.074048
2004-07-01
2024-06-16
Loading full text...

Full text loading...

/content/journals/10.1146/annurev.biochem.73.011303.074048
Loading
/content/journals/10.1146/annurev.biochem.73.011303.074048
Loading

Data & Media loading...

  • Article Type: Review Article
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error