The inositol 1,4,5 trisphosphate (IP) receptor (IPR) is a Ca2+ release channel that responds to the second messenger IP. Exquisite modulation of intracellular Ca2+ release via IPRs is achieved by the ability of IPR to integrate signals from numerous small molecules and proteins including nucleotides, kinases, and phosphatases, as well as nonenzyme proteins. Because the ion conduction pore composes only ∼5% of the IPR, the great bulk of this large protein contains recognition sites for these substances. Through these regulatory mechanisms, IPR modulates diverse cellular functions, which include, but are not limited to, contraction/excitation, secretion, gene expression, and cellular growth. We review the unique properties of the IPR that facilitate cell-type and stimulus-dependent control of function, with special emphasis on protein-binding partners.


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  • Article Type: Review Article
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