1932

Abstract

▪ Abstract 

The low-density lipoprotein receptor (LDLR) is responsible for uptake of cholesterol-carrying lipoprotein particles into cells. The receptor binds lipoprotein particles at the cell surface and releases them in the low-pH environment of the endosome. The focus of the current review is on biochemical and structural studies of the LDLR and its ligands, emphasizing how structural features of the receptor dictate the binding of low-density lipoprotein (LDL) and beta-migrating forms of very low-density lipoprotein (β-VLDL) particles, how the receptor releases bound ligands at low pH, and how the cytoplasmic tail of the LDLR interfaces with the endocytic machinery.

Loading

Article metrics loading...

/content/journals/10.1146/annurev.biochem.74.082803.133354
2005-07-07
2024-06-23
Loading full text...

Full text loading...

/content/journals/10.1146/annurev.biochem.74.082803.133354
Loading
/content/journals/10.1146/annurev.biochem.74.082803.133354
Loading

Data & Media loading...

  • Article Type: Review Article
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error