1932

Abstract

Genome sequencing projects have provided researchers with a complete inventory of the predicted proteins produced by eukaryotic and prokaryotic organisms. Assignment of functions to these proteins represents one of the principal challenges for the field of proteomics. Activity-based protein profiling (ABPP) has emerged as a powerful chemical proteomic strategy to characterize enzyme function directly in native biological systems on a global scale. Here, we review the basic technology of ABPP, the enzyme classes addressable by this method, and the biological discoveries attributable to its application.

Loading

Article metrics loading...

/content/journals/10.1146/annurev.biochem.75.101304.124125
2008-07-07
2024-06-23
Loading full text...

Full text loading...

/content/journals/10.1146/annurev.biochem.75.101304.124125
Loading
/content/journals/10.1146/annurev.biochem.75.101304.124125
Loading

Data & Media loading...

  • Article Type: Review Article
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error