1932

Abstract

Abstract

The positioning of a cytoskeletal element that dictates the division plane is a fundamental problem in biology. The assembly and positioning of this cytoskeletal element has to be coordinated with DNA segregation and cell growth to ensure that equal-sized progeny cells are produced, each with a copy of the chromosome. In most prokaryotes, cytokinesis involves positioning a Z ring assembled from FtsZ, the ancestral homologue of tubulin. The position of the Z ring is determined by a gradient of negative regulators of Z-ring assembly. In , the Min system consists of three proteins that cooperate to position the Z ring through a fascinating oscillation, which inhibits the formation of the Z ring away from midcell. Additional gradients of negative regulators of FtsZ assembly are used by and other bacteria to achieve spatial control of Z-ring assembly.

Keyword(s): cytokinesisFtsZMinDMipZZ ring
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/content/journals/10.1146/annurev.biochem.75.103004.142652
2007-07-07
2024-06-18
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/content/journals/10.1146/annurev.biochem.75.103004.142652
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  • Article Type: Review Article
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