1932

Abstract

Genetic screens in , , and clarified the logic of metazoan development by revealing critical unitary steps and pathways to embryogenesis. Can genetic screens similarly organize medicine? We here examine human diseases that resemble mutations in , the zebrafish, the one vertebrate species for which large-scale genetic screens have been performed and extensively analyzed. Zebrafish mutations faithfully phenocopy many human disorders. Each mutation, once cloned, provides candidate genes and pathways for evaluation in the human. The collection of mutations in their entirety potentially provides a medical taxonomy, one based in developmental biology and genetics.

Loading

Article metrics loading...

/content/journals/10.1146/annurev.genom.3.031402.131506
2002-09-01
2024-06-23
Loading full text...

Full text loading...

/content/journals/10.1146/annurev.genom.3.031402.131506
Loading
/content/journals/10.1146/annurev.genom.3.031402.131506
Loading

Data & Media loading...

  • Article Type: Review Article
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error