1932

Abstract

Abstract

Pharmacogenetics and pharmacogenomics involve the study of the role of inheritance in individual variation in drug response, a phenotype that varies from potentially life-threatening adverse drug reactions to equally serious lack of therapeutic efficacy. This discipline evolved from the convergence of rapid advances in molecular pharmacology and genomics. Originally, pharmacogenetic studies focused on monogenic traits, often involving genetic variation in drug metabolism. However, contemporary studies increasingly involve entire “pathways” encoding proteins that influence both pharmacokinetics—factors that influence the concentration of a drug reaching its target(s)—and pharmacodynamics, the drug target itself, as well as genome-wide approaches. Pharmacogenomics is also increasingly moving across the “translational interface” into the clinic and is being incorporated into the drug development process and the governmental regulation of that process. However, significant challenges remain to be overcome if pharmacogenetics-pharmacogenomics is to achieve its full potential as a major medical application of genomic science.

Loading

Article metrics loading...

/content/journals/10.1146/annurev.genom.6.080604.162315
2006-09-22
2024-12-10
Loading full text...

Full text loading...

/content/journals/10.1146/annurev.genom.6.080604.162315
Loading
/content/journals/10.1146/annurev.genom.6.080604.162315
Loading

Data & Media loading...

  • Article Type: Review Article
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error