1932

Abstract

Lysosome-related organelles (LROs) are a heterogeneous group of vesicles that share various features with lysosomes, but are distinct in function, morphology, and composition. The biogenesis of LROs employs a common machinery, and genetic defects in this machinery can affect all LROs or only an individual LRO, resulting in a variety of clinical features. In this review, we discuss the main components of LRO biogenesis. We also summarize the function, composition, and resident cell types of the major LROs. Finally, we describe the clinical characteristics of the major human LRO disorders.

Loading

Article metrics loading...

/content/journals/10.1146/annurev.genom.9.081307.164303
2008-09-22
2024-06-15
Loading full text...

Full text loading...

/content/journals/10.1146/annurev.genom.9.081307.164303
Loading
/content/journals/10.1146/annurev.genom.9.081307.164303
Loading

Data & Media loading...

  • Article Type: Review Article
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error