1932

Abstract

Current models of signal transduction from the antigen receptors on B and T cells still resemble equations with several unknown elements. Data from recent knock-out experiments in cell lines and mice contradict the assumption that Src-family kinase and tyrosine kinases of the Syk/Zap-70 family are the transducer elements that set signaling from these receptors in motion. Using a functional definition of signaling elements, we discuss the current knowledge of signaling events from the BCR and suggest the existence of an as-yet-unknown BCR transducer complex.

Loading

Article metrics loading...

/content/journals/10.1146/annurev.immunol.15.1.453
1997-04-01
2024-04-19
Loading full text...

Full text loading...

/content/journals/10.1146/annurev.immunol.15.1.453
Loading
/content/journals/10.1146/annurev.immunol.15.1.453
Loading

Data & Media loading...

  • Article Type: Review Article
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error