1932

Abstract

At first one is very pleased at being invited to write a Prefatory Chapter, but as the delivery deadline draws closer one begins to think, “Oh my God! What on earth can I say that all but family members and few close friends will not find a great bore?” One solution is to write a scientific essay, but I concluded that that was a cop-out. I decided that perhaps the best tack to follow was to try to convey to the reader the personal characteristics I bring to my science and to other aspects of my professional career. The writing of this chapter has certainly convinced me that my particular background influenced what problems I chose to work on and how I approached their solution, but I hope that my results have a more ecumenical significance. There's been much written recently about how one's cultural background affects one's science, but I think that thesis can also be exaggerated. Science is a method of inquiry that by using certain guidelines permits rational individuals to observe Nature in a way that their findings will agree and have permanence. We shouldn't be diffident about defending that claim of objectivity.

Loading

Article metrics loading...

/content/journals/10.1146/annurev.immunol.16.1.1
1998-04-01
2024-06-24
Loading full text...

Full text loading...

/deliver/fulltext/immunol/16/1/annurev.immunol.16.1.1.html?itemId=/content/journals/10.1146/annurev.immunol.16.1.1&mimeType=html&fmt=ahah

Literature Cited

  1. Crick F, Watson J. 1953. A structure for deoxyribose nucleic acid.. Nature 171:737–38 [Google Scholar]
  2. Lapresle C, Durieux J. 1957. Etude de la dégradation de la sérumalbumine humaine par un extrait de rate de lapin.. Ann. Inst. Pasteur 92:62–73 [Google Scholar]
  3. Sober HA, Peterson EA. 1958. Protein chromatography on ion exchange cellulose.. Fed. Proc. 17:1116–26 [Google Scholar]
  4. Fahey JL, McCoy PF, Goulian M. 1958. Chromatography of serum proteins in normal and pathologic sera.. J. Clin. Invest. 37:272–84 [Google Scholar]
  5. Cohn EJ, Edsall JT. 1943. Proteins, Amino Acids and Peptides. New York: Reinhold 686 pp. [Google Scholar]
  6. Stetten D Jr, Carrigan WT. eds 1984. NIH: An Account of Research in its Laboratories and Clinics. New York: Academic 554 pp. [Google Scholar]
  7. Bartel AH, Campbell DH. 1959. Some immunochemical differences between associated and dissociated hemocyanin.. Arch. Biochem. Biophys. 82:232–34 [Google Scholar]
  8. Metzger H, Sharp GC, Edelhoch H. 1962. The properties of thyroglobulin.. VII. The immunologic activity of thyroglobulin fragments Biochemistry 1:205–14 [Google Scholar]
  9. Singer SJ, Campbell DH. 1952. Physical chemical studies of soluble antigen-antibody complexes.. I. The valence of precipitating rabbit antibody J. Am. Chem. Soc. 74:1794–802 [Google Scholar]
  10. Singer SJ, Nicolson GL. 1972. The fluid mosaic model of the structure of cell membranes.. Science 175:720–31 [Google Scholar]
  11. Wofsy L, Metzger H, Singer SJ. 1962. Affinity labeling—a general method for labeling the active sites of antibody and enzyme molecules.. Biochemistry 1:1031–39 [Google Scholar]
  12. Metzger H, Wofsy L, Singer SJ. 1963. Affinity labeling of the active sites of antibodies to the 2,4-dinitrophenyl hapten.. Biochemistry 2:979–88 [Google Scholar]
  13. Miller F, Metzger H. 1965. Characterization of a human macroglobulin.. I. The molecular weight of its subunit J. Biol. Chem. 240:3325–33 [Google Scholar]
  14. Ashman RF, Metzger H. 1969. A Waldenström macroglobulin which binds nitrophenyl ligands.. J. Biol. Chem. 244:3405–14 [Google Scholar]
  15. Jerne NK. 1968. Summary: Waiting for the end.. Cold Spring Harbor Symp. Quant. Biol. 32:591–603 [Google Scholar]
  16. Landsteiner K. 1962. The Specificity of Serological Reactions. New York: Dover [Google Scholar]
  17. Edelman GM, Gall WE. 1969. The antibody problem.. Annu. Rev. Biochem. 38:415–66 [Google Scholar]
  18. Metzger H. 1970. The antigen receptor problem.. Annu. Rev. Biochem. 39:889–928 [Google Scholar]
  19. Metzger H. 1974. The effect of antigen binding on the properties of antibody.. Adv. Immunol. 28:169–207 [Google Scholar]
  20. Porter RR. 1959. The hydrolysis of rabbit (gamma)-globulin and antibodies with crystalline papain.. Biochem. J. 73:119–27 [Google Scholar]
  21. Ashman RF, Kaplan AP, Metzger H. 1971. A search for conformational change on ligand binding in a human M macroglobulin.. I. Circular dichroism and hydrogen exchange Immunochemistry 8:627–41 [Google Scholar]
  22. Ashman RF, Metzger H. 1971. A search for conformational change on ligand binding in a human M macroglobulin.. II. Susceptibility to proteolysis Immunochemistry 8:643–56 [Google Scholar]
  23. Reid KB, Lowe DM, Porter RR. 1972. Isolation and characterization of C1q, a subcomponent of the first component of complement, from human and rabbit sera.. Biochem. J. 130:749–63 [Google Scholar]
  24. Osler AG, Lichtenstein LM, Levy DA. 1968. In vitro studies of human reaginic allergy.. Adv. Immunol. 8:183–231 [Google Scholar]
  25. Ishizaka K, Ishizaka T. 1971. IgE and reaginic hypersensitivity.. Ann. NY Acad. Sci. 190:443–56 [Google Scholar]
  26. Eccleston E, Leonard BJ, Lowe JS, Welford HJ. 1973. Basophilic leukaemia in the albino rat and a demonstration of the basopoietin.. Nature New. Biol. 244:73–76 [Google Scholar]
  27. Bazin H, Querinjean P, Beckers A, Heremans JF, Dessy F. 1974. Transplantable immunoglobulin-secreting tumours in rats.. IV. Sixty-three IgE-secreting immunocytoma tumours Immunology 26:713–23 [Google Scholar]
  28. Isersky C, Kulczycki A Jr, Metzger H. 1974. Isolation of IgE from reaginic rat serum.. J. Immunol. 112:1909–19 [Google Scholar]
  29. Kulczycki A Jr, Isersky C, Metzger H. 1974. The interaction of IgE with rat basophilic leukemia cells.. I. Evidence for specific binding of IgE J. Exp. Med. 139:600–16 [Google Scholar]
  30. Lamm ME, Small PA Jr. 1966. Polypeptide chain structure of rabbit immunoglobulins.. II. gamma-M-immunoglobulin Biochemistry 5:267–76 [Google Scholar]
  31. Miller F, Metzger H. 1965. Characterization of a human macroglobulin II.. Distribution of the disulfide bonds J. Biol. Chem. 240:4740–45 [Google Scholar]
  32. Svehag SE, Chesebro B, Bloth B. 1967. Ultrastructure of gamma-M immunoglobulin and alpha macroglobulin: electron-microscopic study.. Science 158:933–36 [Google Scholar]
  33. Metzger H. 1992. Transmembrane signaling: the joy of aggregation.. J. Immunol. 149:1477–87 [Google Scholar]
  34. Keegan AD, Paul WE. 1992. Multichain immune recognition receptors: similarities in structure and signaling pathways.. Immunol. Today 13:63–68 [Google Scholar]
  35. Mendoza GR, Metzger H. 1976. Distribution and valency of receptor for IgE on rodent mast cells and related tumour cells.. Nature 264:548–50 [Google Scholar]
  36. Schlessinger J, Webb WW, Elson EL, Metzger H. 1976. Lateral motion and valence of Fc receptors on rat peritoneal mast cells.. Nature 264:550–52 [Google Scholar]
  37. Segal DM, Taurog JD, Metzger H. 1977. Dimeric immunoglobulin E serves as a unit signal for mast cell degranulation.. Proc. Natl. Acad. Sci. USA 74:2993–97 [Google Scholar]
  38. Holowka D, Hartmann H, Kanellopoulos J, Metzger H. 1980. Association of the receptor for immunoglobulin E with an endogenous polypeptide on rat basophilic leukemia cells.. J. Recept. Res. 1:41–68 [Google Scholar]
  39. Metzger H, Kinet J-P, Perez-Montfort R, Rivnay B, Wank SA. 1983. A tetrameric model for the structure of the mast cell receptor with high affinity for IgE. In Progress in Immunology V, ed. Y Yamamura, T Tada 493–501 Orlando, FL: Academic [Google Scholar]
  40. Bordier C. 1981. Phase separation of integral membrane proteins in Triton X-114 solution.. J. Biol. Chem. 256:1604–7 [Google Scholar]
  41. Kanellopoulos J, Rossi G, Metzger H. 1979. Preparative isolation of the cell receptor for immunoglobulin E.. J. Biol. Chem. 254:7691–97 [Google Scholar]
  42. Alcaraz G, Kinet J-P, Kumar N, Wank SA, Metzger H. 1984. Phase separation of the receptor for immunoglobulin E and its subunits in Triton X-114.. J. Biol. Chem. 259:14922–27 [Google Scholar]
  43. Davenas E, Beauvais F, Amara J, Oberbaum M, Robinzon B, Miadonna A, Tedeschi A, Pomeranz B, Fortner P, Belon P, Sainte-Laudy J, Poitevin B, Benveniste J. 1988. Human basophil degranulation triggered by very dilute antiserum against IgE.. Nature 333:816–18 [Google Scholar]
  44. Metzger H, Dreskin SC. 1988. Only the smile is left.. Nature 334:375 [Google Scholar]
  45. 1988. When to publish pseudo-science.. Nature 334:367 [Google Scholar]
  46. Hirst SJ, Hayes NA, Burridge J, Pearce FL, Foreman JC. 1993. Human basophil degranulation is not triggered by very dilute antiserum against human IgE.. Nature 366:525–27 [Google Scholar]
  47. Wofsy L. 1995. Looking for the Future. Berkeley, CA: IW Rose 148 pp. [Google Scholar]
  48. Frank A, Roth J, Wolfe S, Metzger H. 1969. Medical problems of civil disorders.. Organization of a volunteer group of health professionals to provide medical services in a riot N. Engl. J. Med. 280:247–53 [Google Scholar]
  49. Farrington B. 1961. Greek Science. Baltimore, MD: Penguin 320 pp. [Google Scholar]
  50. Wofsy C, Torigoe C, Kent UM, Metzger H, Goldstein B. 1997. Exploiting the difference between extrinsic and intrinsic kinases: implications for regulation of signaling by immunoreceptors.. J. Immunol. In press [Google Scholar]
/content/journals/10.1146/annurev.immunol.16.1.1
Loading
  • Article Type: Review Article
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error