1932

Abstract

Advances in gene technology have allowed the manipulation of molecular interactions that shape the T cell repertoire. Although recognized as fundamental aspects of T lymphocyte development, only recently have the mechanisms governing positive and negative selection been examined at a molecular level. Positive selection refers to the active process of rescuing MHC-restricted thymocytes from programmed cell death. Negative selection refers to the deletion or inactivation of potentially autoreactive thymocytes. This review focuses on interactions during thymocyte maturation that define the T cell repertoire, with an emphasis placed on current literature within this field.

Loading

Article metrics loading...

/content/journals/10.1146/annurev.immunol.17.1.829
1999-04-01
2024-04-15
Loading full text...

Full text loading...

/content/journals/10.1146/annurev.immunol.17.1.829
Loading
/content/journals/10.1146/annurev.immunol.17.1.829
Loading

Data & Media loading...

  • Article Type: Review Article
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error