The high affinity receptor for immunoglobulin E (designated FcϵRI) is the member of the antigen (Ag) receptor superfamily responsible for linking pathogen- or allergen-specific IgEs with cellular immunologic effector functions. This review provides background information on FcϵRI function combined with more detailed summaries of recent progress in understanding specific aspects of FcϵRI biology and biochemistry. Topics covered include the coordination and function of the large multiprotein signaling complexes that are assembled when FcϵRI and other Ag receptors are engaged, new information on human receptor structures and tissue distribution, and the role of the FcRβ chain in signaling and its potential contribution to atopic phenotypes.

Keyword(s): atopyreceptorsignaling

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  • Article Type: Review Article
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