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Abstract

Abstract

Helper T cells coordinate immune responses through the production of cytokines. Th2 cells express the closely linked , and cytokine genes, whereas these same genes are silenced in the Th1 lineage. The Th1/Th2 lineage choice has become a textbook example for the regulation of cell differentiation, and recent discoveries have further refined and expanded our understanding of how Th2 differentiation is initiated and reinforced by signals from antigen-presenting cells and cytokine-driven feedback loops. Epigenetic changes that stabilize the active or silent state of the locus in differentiating helper T cells have been a major focus of recent research. Overall, the field is progressing toward an integrated model of the signaling and transcription factor networks, cis-regulatory elements, epigenetic modifications, and RNA interference mechanisms that converge to determine the lineage fate and gene expression patterns of differentiating helper T cells.

[Erratum, Closure]

An erratum has been published for this article:
REGULATION OF TH2 DIFFERENTIATION AND LOCUS ACCESSIBILITY
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/content/journals/10.1146/annurev.immunol.23.021704.115821
2006-04-23
2024-06-23
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  • Article Type: Review Article
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