1932

Abstract

Prostaglandins of the E series are implicated as regulators of glucose homeostasis because of their effects on glucose production and secretion of insulin and glueagon. PGE is postulated to play a role in the pathophysiology of insulin secretion in adult-onset (Type II) diabetes mellitus. Evidence supporting this hypothesis includes the demonstration that PGE inhibits glucose-induced acute insulin responses in normal humans. Moreover, drugs that inhibit synthesis of PGE improve abnormal insulin secretion in human subjects with Type II diabetes mellitus.

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/content/journals/10.1146/annurev.me.34.020183.000245
1983-02-01
2024-04-14
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/content/journals/10.1146/annurev.me.34.020183.000245
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  • Article Type: Review Article
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