1932

Abstract

Recent studies have shown that chromosomes shorten as cells divide and become senescent. Also, deletions in mitochondrial DNA increase markedly with advancing age, presumably secondary to damage from oxygen radicals. Since host defenses against environmental factors also become attenuated, the molecular damage associated with aging may increasingly perturb normal homeostasis and increase the susceptibility to disease and disability. Such age-associated dysfunctions can be targeted and interrupted.

Loading

Article metrics loading...

/content/journals/10.1146/annurev.me.44.020193.002223
1993-02-01
2024-12-05
Loading full text...

Full text loading...

/content/journals/10.1146/annurev.me.44.020193.002223
Loading
  • Article Type: Review Article
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error