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Abstract

Salmonellae are gram-negative bacteria that cause gastroenteritis and enteric fever. virulence requires the coordinated expression of complex arrays of virulence factors that allow the bacterium to evade the host's immune system. All serotypes share the ability to invade the host by inducing their own uptake into cells of the intestinal epithelium. In addition, serotypes associated with gastroenteritis orchestrate an intestinal inflammatory and secretory response, whereas serotypes that cause enteric fever establish systemic infection through their ability to survive and replicate in mononuclear phagocytes. This review explores the molecular basis of selected virulence strategies, with an emphasis on general themes of bacterial pathogenesis as exemplified by .

[Erratum, Closure]

An erratum has been published for this article:
SALMONELLA: A Model for Bacterial Pathogenesis
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/content/journals/10.1146/annurev.med.52.1.259
2001-02-01
2024-04-14
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  • Article Type: Review Article
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