Genetic resistance to infectious diseases is likely to involve a complex array of immune-response and other genes with variants that impose subtle but significant consequences on gene expression or protein function. We have gained considerable insight into the genetic determinants of HIV-1 disease, and the class I genes appear to be highly influential in this regard. Numerous reports have identified a role for genotype in AIDS outcomes, implicating many alleles in various aspects of HIV disease. Here we review the associations with progression to AIDS that have been consistently affirmed and discuss the underlying mechanisms behind some of these associations based on functional studies of immune cell recognition.


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  • Article Type: Review Article
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