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Abstract

Abstract

The currently recommended treatment for individuals exposed to rabies virus is the combined administration of rabies vaccine and rabies immune globulin (RIG). This review sets out the criteria used to guide development of a cocktail of human monoclonal antibodies as a replacement for RIG. Using this process as a model, the general requirements for development of safe and efficacious monoclonal antibody alternatives to currently used polyclonal serum products are discussed.

Keyword(s): IgGphage displaypolyclonalserum
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/content/journals/10.1146/annurev.med.58.061705.145053
2007-02-18
2024-04-22
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  • Article Type: Review Article
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