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Abstract

Abstract

Tularemia is a zoonosis of humans caused by infection with the facultative intracellular bacterium . Interest in has increased markedly in the past few years because of its potential use as an agent of bioterrorism. Five subspecies of this organism are found in the Northern hemisphere, but only subsp. and subsp. cause disease in humans. This review summarizes what is known about the pathogenesis of tularemia with a focus on bacterial surface components such as lipopolysaccharide and capsule as well as information obtained from the subsp. SCHU S4 genome. In particular, the mechanisms of action of recently identified virulence factors are discussed in the context of bacterial replication in macrophages and manipulation of the host inflammatory response. Throughout this report, shared and unique features of subsp. , subsp. , and subsp. are discussed.

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/content/journals/10.1146/annurev.micro.60.080805.142126
2006-10-13
2024-04-16
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  • Article Type: Review Article
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