1932

Abstract

The -translation mechanism is a key component of multiple quality control pathways in bacteria that ensure proteins are synthesized with high fidelity in spite of challenges such as transcription errors, mRNA damage, and translational frameshifting. -Translation is performed by a ribonucleoprotein complex composed of tmRNA, a specialized RNA with properties of both a tRNA and an mRNA, and the small protein SmpB. tmRNA-SmpB interacts with translational complexes stalled at the 3′ end of an mRNA to release the stalled ribosomes and target the nascent polypeptides and mRNAs for degradation. In addition to quality control pathways, some genetic regulatory circuits use -translation to control gene expression. Diverse bacteria require -translation when they execute large changes in their genetic programs, including responding to stress, pathogenesis, and differentiation.

Loading

Article metrics loading...

/content/journals/10.1146/annurev.micro.62.081307.162948
2008-10-13
2024-06-25
Loading full text...

Full text loading...

/content/journals/10.1146/annurev.micro.62.081307.162948
Loading
/content/journals/10.1146/annurev.micro.62.081307.162948
Loading

Data & Media loading...

  • Article Type: Review Article
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error