1932

Abstract

The resin of the tree has been used in Ayurvedic medicine for more than 2000 years to treat a variety of ailments. Studies in both animal models and humans have shown that this resin, termed gum guggul, can decrease elevated lipid levels. The stereoisomers E- and Z-guggulsterone have been identified as the active agents in this resin. Recent studies have shown that these compounds are antagonist ligands for the bile acid receptor farnesoid X receptor (FXR), which is an important regulator of cholesterol homeostasis. It is likely that this effect accounts for the hypolipidemic activity of these phytosteroids.

Loading

Article metrics loading...

/content/journals/10.1146/annurev.nutr.23.011702.073102
2003-07-01
2024-06-23
Loading full text...

Full text loading...

/content/journals/10.1146/annurev.nutr.23.011702.073102
Loading
/content/journals/10.1146/annurev.nutr.23.011702.073102
Loading

Data & Media loading...

  • Article Type: Review Article
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error