1932

Abstract

▪ Abstract 

Many proteins present on cell surfaces and located in extracellular fluids contain cysteine and methionine residues that are subject to oxidation. These proteins, which include transporters, receptors, and enzymes, respond to variations in the extracellular thiol/disulfide redox environment. Changes in activity of these proteins can alter the ability of organs to function normally and influence processes such as nutritional absorption, secretory function, neurotransmission, and susceptibility to toxicants. In addition, extracellular redox can regulate tissue homeostasis through effects on cell proliferation, differentiation, apoptosis, and immune function. Consequently, extracellular redox can have important influences on health status and disease states and thus could be a target for nutritional interventions.

Loading

Article metrics loading...

/content/journals/10.1146/annurev.nutr.24.012003.132208
2004-07-14
2024-07-18
Loading full text...

Full text loading...

/content/journals/10.1146/annurev.nutr.24.012003.132208
Loading
/content/journals/10.1146/annurev.nutr.24.012003.132208
Loading

Data & Media loading...

  • Article Type: Review Article
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error