1932

Abstract

This essay is an account of the author’s experience in trying to interpret the action of drugs as seen in in vitro bioassays. The central theme is how the development of simple mathematical models has assisted in the interpretation of drug actions. Starting from encounters with partial agonists, the essay describes the development of an operational model of agonist activity, the significance of receptor distribution, the analysis of indirect competitive antagonism and various two-receptor systems, followed by examples of pharmacological resultant activity. Analyses of tissue and species variations are described. The essay ends with an assessment of the future of bioassay in pharmacology

Loading

Article metrics loading...

/content/journals/10.1146/annurev.pa.36.040196.000245
1996-04-01
2024-06-25
Loading full text...

Full text loading...

/content/journals/10.1146/annurev.pa.36.040196.000245
Loading
  • Article Type: Review Article
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error