Metabolism of Fluorine-Containing Drugs

B Kevin Park; Neil R Kitteringham; Paul M O'Neill

doi:10.1146/annurev.pharmtox.41.1.443

Annual Review of Pharmacology and Toxicology

Volume 41, 2001

Review Article

Metabolism of Fluorine-Containing Drugs

B Kevin Park¹, Neil R Kitteringham¹, and Paul M O'Neill¹
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Affiliations: Department of Pharmacology and Therapeutics, New Medical Building, University of Liverpool, Liverpool, United Kingdom; e-mail: [email protected][email protected][email protected]
Vol. 41:443-470 (Volume publication date April 2001) https://doi.org/10.1146/annurev.pharmtox.41.1.443
© Annual Reviews

Abstract

This article reviews current knowledge of the metabolism of drugs that contain fluorine. The strategic value of fluorine substitution in drug design is discussed in terms of chemical structure and basic concepts in drug metabolism and drug toxicity.

Keyword(s): defluorination, drug design, drug metabolism, drug safety, drug toxicity, metabolic stability

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2001-04-01

2025-04-24

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Metabolism of Fluorine-Containing Drugs

Annual Review of Pharmacology and Toxicology 41, 443 (2001); https://doi.org/10.1146/annurev.pharmtox.41.1.443

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Article Type: Review Article

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Annual Review of Pharmacology and Toxicology

Volume 41, 2001

Review Article

Metabolism of Fluorine-Containing Drugs

Abstract

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