1932

Abstract

P-glycoprotein is an ATP-dependent efflux pump that contributes to the protection of the body from environmental toxins. It transports a huge variety of structurally diverse compounds. P-glycoprotein is involved in limiting absorption of xenobiotics from the gut lumen, in protection of sensitive tissues (brain, fetus, testis), and in biliary and urinary excretion of its substrates. P-glycoprotein can be inhibited or induced by xenobiotics, thereby contributing to variable drug disposition and drug interactions. Recently, several SNPs have been identified in the gene, some of which can affect P-glycoprotein expression and function. Potential implications of polymorphisms for drug disposition, drug effects, and disease risk are discussed.

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/content/journals/10.1146/annurev.pharmtox.43.100901.140233
2003-04-01
2024-06-23
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  • Article Type: Review Article
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