▪ Abstract 

The main role of blood platelets is to ensure primary hemostasis, which is the maintenance of vessel integrity and cessation of bleeding upon injury. While playing a major part in acute arterial thrombosis, platelets are also involved in inflammation, atherosclerosis, and angiogenesis. ADP and ATP play a crucial role in platelet activation, and their receptors are potential targets for antithrombotic drugs. The ATP-gated cation channel P2X and the two G protein–coupled ADP receptors, P2Y and P2Y, selectively contribute to platelet aggregation and formation of a thrombus. Owing to its central role in the growth and stabilization of a thrombus, the P2Y receptor is an established target of antithrombotic drugs such as clopidogrel. Studies in P2Y and P2X knockout mice and selective P2Y and P2X antagonists have shown that these receptors are also attractive targets for new antithrombotic compounds. The potential role of platelet P receptors in the involvement of platelets in inflammatory processes is also discussed.

Keyword(s): ADPhemostasisP2X1P2Y1P2Y12thrombosis

Article metrics loading...

Loading full text...

Full text loading...


Data & Media loading...

  • Article Type: Review Article
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error