1932

Abstract

c-MYC is an important regulator of a wide array of cellular processes necessary for normal cell growth and differentiation, and its dysregulation is one of the hallmarks of many cancers. Consequently, understanding c- transcriptional activation is critical for understanding developmental and cancer biology, as well as for the development of new anticancer drugs. The nuclease hypersensitive element (NHE) III region of the c- promoter has been shown to be particularly important in regulating c- expression. Specifically, the formation of a G-quadruplex structure appears to promote repression of c- transcription. This review focuses on what is known about the formation of a G-quadruplex in the NHE III region of the c- promoter, as well as on those factors that are known to modulate its formation. Last, we discuss the development of small molecules that stabilize or induce the formation of G-quadruplex structures and could potentially be used as anticancer agents.

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/content/journals/10.1146/annurev.pharmtox.48.113006.094649
2010-02-10
2024-04-13
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  • Article Type: Review Article
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