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Annual Review of Microbiology

Volume 76, 2022

Oxygenases as Powerful Weapons in the Microbial Degradation of Pesticides

Abstract

Oxygenases, which catalyze the reductive activation of O and incorporation of oxygen atoms into substrates, are widely distributed in aerobes. They function by switching the redox states of essential cofactors that include flavin, heme iron, Rieske non-heme iron, and Fe(II)/α-ketoglutarate. This review summarizes the catalytic features of flavin-dependent monooxygenases, heme iron–dependent cytochrome P450 monooxygenases, Rieske non-heme iron–dependent oxygenases, Fe(II)/α-ketoglutarate-dependent dioxygenases, and ring-cleavage dioxygenases, which are commonly involved in pesticide degradation. Heteroatom release (hydroxylation-coupled hetero group release), aromatic/heterocyclic ring hydroxylation to form ring-cleavage substrates, and ring cleavage are the main chemical fates of pesticides catalyzed by these oxygenases. The diversity of oxygenases, specificities for electron transport components, and potential applications of oxygenases are also discussed. This article summarizes our current understanding of the catalytic mechanisms of oxygenases and a framework for distinguishing the roles of oxygenases in pesticide degradation.

Keyword(s): catalytic feature, chemical reaction fate, oxygenase, pesticide degradation
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2022-09-08
2024-05-05
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/content/journals/10.1146/annurev-micro-041320-091758
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Oxygenases as Powerful Weapons in the Microbial Degradation of Pesticides
Annual Review of Microbiology 76, 325 (2022); https://doi.org/10.1146/annurev-micro-041320-091758
/content/journals/10.1146/annurev-micro-041320-091758
/content/journals/10.1146/annurev-micro-041320-091758
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