1932
0
  1. Home
  2. A-Z Publications
  3. Annual Review of Biochemistry
  4. Volume 67, 1998
  5. Article

Annual Review of Biochemistry

Volume 67, 1998

ROLE OF SMALL G PROTEINS IN YEAST CELL POLARIZATION AND WALL BIOSYNTHESIS1

Abstract

In the vegetative (mitotic) cycle and during sexual conjugation, yeast cells display polarized growth, giving rise to a bud or to a mating projection, respectively. In both cases one can distinguish three steps in these processes: choice of a growth site, organization of the growth site, and actual growth and morphogenesis. In all three steps, small GTP-binding proteins (G proteins) and their regulators play essential signaling functions. For the choice of a bud site, Bud1, a small G protein, Bud2, a negative regulator of Bud1, and Bud5, an activator, are all required. If any of them is defective, the cell loses its ability to select a proper bud position and buds randomly. In the organization of the bud site or of the site in which a mating projection appears, Cdc42, its activator Cdc24, and its negative regulators play a fundamental role. In the absence of Cdc42 or Cdc24, the actin cytoskeleton does not become organized and budding does not take place. Finally, another small G protein, Rho1, is required for activity of β(1 → 3)glucan synthase, the enzyme that catalyzes the synthesis of the major structural component of the yeast cell wall. In all of the above processes, G proteins can work as molecular switches because of their ability to shift between an active GTP-bound state and an inactive GDP-bound state.

Keyword(s): Bud1/Rsr1, budding, Cdc42, Rho1, β(1 → 3)glucan synthase
Loading

Article metrics loading...

/content/journals/10.1146/annurev.biochem.67.1.307
1998-07-01
2024-06-10
Loading full text...

Full text loading...

/deliver/fulltext/biochem/67/1/annurev.biochem.67.1.307.html?itemId=/content/journals/10.1146/annurev.biochem.67.1.307&mimeType=html&fmt=ahah

Literature Cited

  1. Boguski MS, McCormick F. 1993. Nature 366:643–54 [Google Scholar]
  2. Mösch H-U, Roberts RL, Fink GR. 1996. Proc. Natl. Acad. Sci. USA 93:5352–56 [Google Scholar]
  3. Winge O. 1935. C. R. Lab. Carlsberg. Ser. Physiol. 21:77–111 [Google Scholar]
  4. Freifelder D. 1960. J. Bacteriol. 124:511–23 [Google Scholar]
  5. Streiblova E. 1970. Can. J. Microbiol. 16:827–31 [Google Scholar]
  6. Hicks J, Strathern JN. 1977. Brookhaven Symp. Biol. 29:233–42 [Google Scholar]
  7. Herskowitz I, Park HO, Sanders S, Valtz N, Peter M. 1995. Cold Spring Harbor Symp. Quant. Biol. 60:717–27 [Google Scholar]
  8. Sanders SL, Field CM. 1995. Curr. Biol. 5:1213–15 [Google Scholar]
  9. Chant J, Pringle JR. 1991. Curr. Opin. Genet. Dev. 1:342–50 [Google Scholar]
  10. Roemer T, Vallier LG, Snyder M. 1996. Trends Cell Biol. 6:434–41 [Google Scholar]
  11. Cid VJ, Duran A, del Rey F, Snyder MP, Nombela C, Sanchez M. 1995. Microbiol. Rev. 59:345–86 [Google Scholar]
  12. Chant J. 1996. Curr. Opin. Cell Biol. 8:557–65 [Google Scholar]
  13. Chant J, Herskowitz I. 1991. Cell 65:1203–12 [Google Scholar]
  14. Park H-O, Chant J, Herskowitz I. 1993. Nature 365:269–74 [Google Scholar]
  15. Cvrckova F, Nasmyth K. 1993. EMBO J. 12:5277–86 [Google Scholar]
  16. Benton BK, Tinklenberg AH, Jean D, Plump SD, Cross FR. 1993. EMBO J. 12:5267–75 [Google Scholar]
  17. Powers S, Gonzales E, Christensen T, Cubert J, Broek D. 1991. Cell 65:1225–31 [Google Scholar]
  18. Chant J, Corrado K, Pringle JR, Herskowitz I. 1991. Cell 65:1213–24 [Google Scholar]
  19. Bender A, Pringle JR. 1989. Proc. Natl. Acad. Sci. USA 86:9976–80 [Google Scholar]
  20. Pringle JR, Bi E, Harkins HA, Zahner JE, De Virgilio C. et al. 1995. Cold Spring Harbor Symp. Quant. Biol. 60:729–44 [Google Scholar]
  21. Chant J, Mischke M, Mitchell E, Herskowitz I, Pringle JR. 1995. J. Cell Biol. 129:767–78 [Google Scholar]
  22. Sanders SL, Herskowitz I. 1996. J. Cell Biol. 134:413–27 [Google Scholar]
  23. Fujita A, Oka C, Arikawa Y, Katagai T, Tonouchi A. et al. 1994. Nature 372:567–70 [Google Scholar]
  24. Roemer T, Madden K, Chang JT, Snyder M. 1996. Genes Dev. 10:777–93 [Google Scholar]
  25. Halme A, Michelitch M, Mitchell EL, Chant J. 1996. Curr. Biol. 6:570–79 [Google Scholar]
  26. Yang S, Ayscough KR, Drubin DG. 1997. J. Cell Biol. 136:111–23 [Google Scholar]
  27. Snyder M. 1989. J. Cell Biol. 108:1419–29 [Google Scholar]
  28. Bauer F, Urdaci M, Aigle M, Crouzet M. 1993. Mol. Cell. Biol. 13:5070–84 [Google Scholar]
  29. Drubin DG, Jones HD, Wertman KF. 1993. Mol. Biol. Cell 4:1277–94 [Google Scholar]
  30. Sivadon P, Bauer F, Aigle M, Crouzet M. 1995. Mol. Gen. Genet. 246:485–95 [Google Scholar]
  31. Durrens P, Revardel E, Bonneu M, Aigle M. 1995. Curr. Genet. 27:213–16 [Google Scholar]
  32. Zahner JE, Harkins HA, Pringle JR. 1996. Mol. Cell. Biol. 16:1857–70 [Google Scholar]
  33. White GC, Crawford N, Fischer TH. 1993. Adv. Exp. Med. Biol. 344:187–94 [Google Scholar]
  34. Ruggieri R, Bender A, Matsui Y, Powers S, Takai Y. et al. 1992. Mol. Cell. Biol. 12:758–66 [Google Scholar]
  35. Neufeld TP, Rubin GM. 1994. Cell 77:371–79 [Google Scholar]
  36. McCabe PC, Haubruck H, Polakis P, McCormick F, Innis MA. 1992. Mol. Cell. Biol. 12:4084–92 [Google Scholar]
  37. Drubin DG, Nelson JW. 1996. Cell 84:335–44 [Google Scholar]
  38. Chant J, Pringle JR. 1995. J. Cell Biol. 129:751–65 [Google Scholar]
  39. Chant J. 1996. Cell 84:187–90 [Google Scholar]
  40. Kim HB, Haarer BK, Pringle JR. 1991. J. Cell Biol. 112:535–44 [Google Scholar]
  41. Haarer BK, Pringle JR. 1987. Mol. Cell. Biol. 7:3678–87 [Google Scholar]
  42. Ford SK, Pringle JR. 1991. Dev. Genet. 12:281–92 [Google Scholar]
  43. Flescher EG, Madden K, Snyder M. 1993. J. Cell Biol. 122:373–86 [Google Scholar]
  44. Michelitch M, Chant J. 1996. Curr. Biol. 6:446–54 [Google Scholar]
  45. Gimeno CJ, Ljungdahl PO, Styles CA, Fink GR. 1992. Cell 68:1077–90 [Google Scholar]
  46. Bender A. 1993. Proc. Natl. Acad. Sci. USA 90:9926–29 [Google Scholar]
  47. Park H-O, Bi EF, Pringle JR, Herskowitz I. 1997. Proc. Natl. Acad. Sci. USA 94:4463–68 [Google Scholar]
  48. Kilmartin JV, Adams AEM. 1984. J. Cell Biol. 98:922–33 [Google Scholar]
  49. Waddle JA, Karpova TS, Waterston RH, Cooper JA. 1996. J. Cell Biol. 132:861–70 [Google Scholar]
  50. Doyle T, Botstein D. 1996. Proc. Natl. Acad. Sci. USA 93:3886–91 [Google Scholar]
  51. Adams AEM, Johnson DI, Longnecker RM, Sloat BF, Pringle J. 1990. J. Cell Biol. 111:131–42 [Google Scholar]
  52. Preuss D, Mulholland J, Franzusoff A, Segev N, Botstein D. 1992. Mol. Biol. Cell 3:789–803 [Google Scholar]
  53. Deleted in proof
  54. Sloat BF, Pringle JR. 1978. Science 200:1171–73 [Google Scholar]
  55. Sloat BF, Adams A, Pringle JR. 1981. J. Cell Biol. 89:395–405 [Google Scholar]
  56. Chenevert J, Corrado K, Bender A, Pringle J, Herskowitz I. 1992. Nature 356:77–79 [Google Scholar]
  57. Mulholland J, Preuss D, Moon A, Wong A, Drubin D, Botstein D. 1994. J. Cell Biol. 125:381–91 [Google Scholar]
  58. Ziman M, Preuss D, Mulholland J, O'Brien JM, Botstein D, Johnson DI. 1993. Mol. Biol. Cell. 4:1307–16 [Google Scholar]
  59. Johnson DI, Pringle JR. 1990. J. Cell Biol. 111:143–52 [Google Scholar]
  60. Miller PJ, Johnson DI. 1997. Yeast 13:561–72 [Google Scholar]
  61. Shinjo K, Koland JG, Hart MJ, Narasimhan V, Johnson DI. et al. 1990. Proc. Natl. Acad. Sci. USA 87:9853–57 [Google Scholar]
  62. Munemitsu S, Innis MA, Clark R, McCormick F, Ullrich A, Polakis P. 1990. Mol. Cell. Biol. 10:5977–82 [Google Scholar]
  63. Fawell E, Bowden S, Armstrong J. 1992. Gene 114:153–54 [Google Scholar]
  64. Miller PJ, Johnson DI. 1994. Mol. Cell. Biol. 14:1075–83 [Google Scholar]
  65. Chen WN, Lim HH, Lim L. 1993. J. Biol. Chem. 268:13280–85 [Google Scholar]
  66. Lew DJ, Reed SI. 1995. Curr. Opin. Genet. Dev. 5:17–23 [Google Scholar]
  67. Li R, Zheng Y, Drubin DG. 1995. J. Cell Biol. 128:599–615 [Google Scholar]
  68. Lechler T, Li R. 1997. J. Cell Biol. 138:95–103 [Google Scholar]
  69. Li R. 1997. J. Cell Biol. 136:649–58 [Google Scholar]
  70. Drubin DG, Mulholland J, Zhu ZM, Botstein D. 1990. Nature 343:288–90 [Google Scholar]
  71. Peterson J, Zheng Y, Bender L, Myers A, Cerione R, Bender A. 1994. J. Cell Biol. 127:1395–406 [Google Scholar]
  72. Zheng Y, Bender A, Cerione RA. 1995. J. Biol. Chem. 270:626–30 [Google Scholar]
  73. Zheng Y, Cerione R, Bender A. 1994. J. Biol. Chem. 269:2369–72 [Google Scholar]
  74. Leeuw T, Fourest-Lieuvin A, Wu CL, Chenevert J, Clark K. et al. 1995. Science 270:1210–13 [Google Scholar]
  75. Jansen R-P, Dowzer C, Michaelis C, Galova M, Nasmyth K. 1996. Cell 84:687–97 [Google Scholar]
  76. Kohno H, Tanaka K, Mino A, Umikawa M, Imamura H. et al. 1996. EMBO J. 15:6060–68 [Google Scholar]
  77. Evangelista M, Blundell K, Longtine MS, Chow CJ, Adames N. et al. 1997. Science 276:118–22 [Google Scholar]
  78. Narumiya S. 1996. J. Biochem. 120:215–28 [Google Scholar]
  79. Kimura K, Ito M, Amano M, Chihara K, Fukata Y. et al. 1996. Science 273:245–48 [Google Scholar]
  80. Qadota H, Anraku Y, Botstein D, Ohya Y. 1994. Proc. Natl. Acad. Sci. USA 91:9317–21 [Google Scholar]
  81. Pantaloni D, Carlier MF. 1993. Cell 75:1007–14 [Google Scholar]
  82. Ayscough KR, Drubin DG. 1996. Annu. Rev. Cell Dev. Biol. 12:129–60 [Google Scholar]
  83. Tapon N, Hall A. 1997. Curr. Opin. Cell Biol. 9:86–92 [Google Scholar]
  84. Manser E, Leung T, Salihuddin H, Zhao ZS, Lim L. 1994. Nature 367:40–46 [Google Scholar]
  85. Leberer E, Dignard D, Harcus D, Thomas DY, Whiteway M. 1992. EMBO J. 11:4815–24 [Google Scholar]
  86. Cvrckova F, De Virgilio C, Manser E, Pringle JR, Nasmyth K. 1995. Genes Dev. 9:1817–30 [Google Scholar]
  87. Peter M, Neiman AM, Park H-O, van Lohuizen M, Herskowitz I. 1996. EMBO J. 15:7046–59 [Google Scholar]
  88. Ramer SW, Davis RW. 1993. Proc. Natl. Acad. Sci. USA 90:452–56 [Google Scholar]
  89. Zarzov P, Mazzoni C, Mann C. 1996. EMBO J. 15:83–91 [Google Scholar]
  90. Zhao Z-S, Leung T, Manser E, Lim L. 1995. Mol. Cell. Biol. 15:5246–57 [Google Scholar]
  91. Simon M-N, De Virgilio C, Souza B, Pringle JR, Abo A, Reed SI. 1995. Nature 376:702–5 [Google Scholar]
  92. Akada R, Kallal L, Johnson DI, Kurjan J. 1996. Genetics 143:103–17 [Google Scholar]
  93. Bender A, Pringle JR. 1991. Mol. Cell. Biol. 11:1295–305 [Google Scholar]
  94. Finegold AA, Johnson DI, Farnsworth CC, Gelb MH, Judd SR. et al. 1991. Proc. Natl. Acad. Sci. USA 88:4448–52 [Google Scholar]
  95. Ohya Y, Qadota H, Anraku Y, Pringle JR, Botstein D. 1993. Mol. Biol. Cell 4:1017–25 [Google Scholar]
  96. Ziman M, O'Brien JM, Ouellette LA, Church WR, Johnson DI. 1991. Mol. Cell. Biol. 11:3537–44 [Google Scholar]
  97. Stevenson BJ, Ferguson B, De Virgilio C, Bi E, Pringle JR. et al. 1995. Genes Dev. 9:2949–63 [Google Scholar]
  98. Zheng Y, Glaven JA, Wu WJ, Cerione RA. 1996. J. Biol. Chem. 271:23815–19 [Google Scholar]
  99. Schmidt A, Kunz J, Hall MN. 1996. Proc. Natl. Acad. Sci. USA 93:13780–85 [Google Scholar]
  100. Schmidt A, Bickle M, Beck T, Hall MN. 1997. Cell 88:531–42 [Google Scholar]
  101. Chong LD, Traynor-Kaplan A, Bokoch GM, Schwartz MA. 1994. Cell 79:507–13 [Google Scholar]
  102. Mack D, Nishimura K, Dennehey BK, Arbogast T, Parkinson J. et al. 1996. Mol. Cell. Biol. 16:4387–95 [Google Scholar]
  103. Bender L, Lo HS, Lee H, Kokojan V, Peterson J, Bender A. 1996. J. Cell Biol. 133:879–94 [Google Scholar]
  104. Imamura H, Tanaka K, Hirata T, Umikawa M, Kamei T. et al. 1997. EMBO J. 16:2745–55 [Google Scholar]
  105. Chant J, Stowers L. 1995. Cell 81:1–4 [Google Scholar]
  106. Symons M. 1996. Trends Biochem. Sci. 21:178–81 [Google Scholar]
  107. Tkacz JS, MacKay VL. 1979. J. Cell Biol. 80:326–33 [Google Scholar]
  108. Segall JE. 1993. Proc. Natl. Acad. Sci. USA 90:8332–36 [Google Scholar]
  109. Hasek J, Rupes I, Svobodova J, Streiblova E. 1987. J. Gen. Microbiol. 133:3355–63 [Google Scholar]
  110. Chenevert J. 1994. Mol. Biol. Cell 5:1169–75 [Google Scholar]
  111. Chenevert J, Valtz N, Herskowitz I. 1994. Genetics 136:1287–96 [Google Scholar]
  112. Jackson CL, Konopka JB, Hartwell LH. 1991. Cell 67:389–402 [Google Scholar]
  113. Valtz N, Peter M, Herskowitz I. 1995. J. Cell Biol. 131:863–73 [Google Scholar]
  114. Dorer R, Pryciak PM, Hartwell LH. 1995. J. Cell Biol. 131:845–61 [Google Scholar]
  115. Klis FM. 1994. Yeast 10:851–69 [Google Scholar]
  116. Sentandreu R, Elorza MV, Villanueva JR. 1975. J. Gen. Microbiol. 90:13–20 [Google Scholar]
  117. Shematek EM, Braatz JA, Cabib E. 1980. J. Biol. Chem. 255:888–94 [Google Scholar]
  118. Shematek EM, Cabib E. 1980. J. Biol. Chem. 255:895–902 [Google Scholar]
  119. Szaniszlo PJ, Kang MS, Cabib E. 1985. J. Bacteriol. 161:1188–94 [Google Scholar]
  120. Kang MS, Cabib E. 1986. Proc. Natl. Acad. Sci. USA 83:5808–12 [Google Scholar]
  121. Mol PC, Park HM, Mullins JT, Cabib E. 1994. J. Biol. Chem. 269:31267–74 [Google Scholar]
  122. Madaule P, Axel R, Myers AM. 1987. Proc. Natl. Acad. Sci. USA 84:779–83 [Google Scholar]
  123. Matsui Y, Toh-e A. 1992. Gene 114:43–49 [Google Scholar]
  124. Drgonová J, Drgon T, Tanaka K, Kollár R, Chen GC. et al. 1996. Science 272:277–79 [Google Scholar]
  125. Qadota H, Python CP, Inoue SB, Arisawa M, Anraku Y. et al. 1996. Science 272:279–81 [Google Scholar]
  126. McCaffrey M, Johnson JS, Goud B, Myers AM, Rossier J. et al. 1991. J. Cell Biol. 115:309–19 [Google Scholar]
  127. Inoue SB, Takewaki N, Takasuka T, Mio T, Adachi M. et al. 1995. Eur. J. Biochem. 231:845–54 [Google Scholar]
  128. Mazur P, Morin N, Baginsky W, El-Sherbeini M, Clemas JA. et al. 1995. Mol. Cell. Biol. 15:5671–81 [Google Scholar]
  129. Douglas CM, Marrinan JA, Li W, Kurtz MB. 1994. J. Bacteriol. 176:5686–96 [Google Scholar]
  130. Douglas CM, Foor F, Marrinan JA, Morin N, Nielsen JB. et al. 1994. Proc. Natl. Acad. Sci. USA 91:12907–11 [Google Scholar]
  131. Parent SA, Nielsen JB, Morin N, Chrebet G, Ramadan N. et al. 1993. J. Gen. Microbiol. 139:2973–84 [Google Scholar]
  132. Castro C, Ribas JC, Valdivieso MH, Varona P, del Rey F, Durán A. 1995. J. Bacteriol. 177:5732–39 [Google Scholar]
  133. Mazur P, Baginsky W. 1996. J. Biol. Chem. 271:14604–9 [Google Scholar]
  134. Yamochi W, Tanaka K, Nonaka H, Maeda A, Musha T, Takai Y. 1994. J. Cell Biol. 125:1077–93 [Google Scholar]
  135. Cabib E, Bowers B, Roberts RL. 1983. Proc. Natl. Acad. Sci. USA 80:3318–21 [Google Scholar]
  136. Ozaki K, Tanaka K, Imamura H, Hihara T, Kameyama T. et al. 1996. EMBO J. 15:2196–207 [Google Scholar]
  137. Kim YJ, Francisco L, Chen GC, Marcotte E, Chan CSM. 1994. J. Cell Biol. 127:1381–94 [Google Scholar]
  138. Chen GC, Zheng L, Chan CSM. 1996. Mol. Cell. Biol. 16:1376–90 [Google Scholar]
  139. Muller L, Xu G, Wells R, Hollenberg CP, Piepersberg W. 1994. Nucleic Acids Res. 22:3151–54 [Google Scholar]
  140. Masuda T, Tanaka K, Nonaka H, Yamochi W, Maeda A, Takai Y. 1994. J. Biol. Chem. 269:19713–18 [Google Scholar]
  141. Nonaka H, Tanaka K, Hirano H, Fujiwara T, Kohno H. et al. 1995. EMBO J. 14:5931–38 [Google Scholar]
  142. Kamada Y, Qadota H, Python CP, Anraku Y, Ohya Y, Levin DE. 1996. J. Biol. Chem. 271:9193–96 [Google Scholar]
  143. Levin DE, Bartlett-Heubusch E. 1992. J. Cell Biol. 116:1221–29 [Google Scholar]
  144. Lee KS, Irie K, Gotoh Y, Watanabe Y, Araki H. et al. 1993. Mol. Cell. Biol. 13:3067–75 [Google Scholar]
  145. Errede B, Levin DE. 1993. Curr. Opin. Cell Biol. 5:254–60 [Google Scholar]
  146. Levin DE, Bowers B, Chen CY, Kamada Y, Watanabe M. 1994. Cell. Mol. Biol. Res. 40:229–39 [Google Scholar]
  147. Roemer T, Paravicini G, Payton MA, Bussey H. 1994. J. Cell Biol. 127:567–79 [Google Scholar]
  148. Kollár R, Reinhold BB, Petráková E, Yeh HJC, Ashwell G. et al. 1997. J. Biol. Chem. 272:17762–75 [Google Scholar]
  149. Madden K, Sheu YJ, Baetz K, Andrews B, Snyder M. 1997. Science 275:1781–84 [Google Scholar]
  150. Marini NJ, Meldrum E, Bueher B, Hubberstey AV, Stone DE. et al. 1996. EMBO J. 15:3040–52 [Google Scholar]
  151. Gray JV, Ogas JP, Kamada Y, Stone M, Levin DE, Herskowitz I. 1997. EMBO J. 16:4924–37 [Google Scholar]
  152. Levin DE, Fields FU, Kurusawa R, Bishop JM, Thorner J. 1990. Cell 62:213–24 [Google Scholar]
  153. Novick P, Botstein D. 1985. Cell 40:405–16 [Google Scholar]
  154. Matsui Y, Toh-e A. 1992. Mol. Cell. Biol. 12:5690–99 [Google Scholar]
  155. Imai J, Toh-e A, Matsui Y. 1996. Genetics 142:359–69 [Google Scholar]
  156. Matsui Y, Matsui R, Akada R, Toh-e A. 1996. J. Cell Biol. 133:865–78 [Google Scholar]
  157. Yu YX, Jiang YW, Wellinger RJ, Carlson K, Roberts JM, Stillman DJ. 1996. Mol. Cell. Biol. 16:5254–63 [Google Scholar]
  158. Rothman JE, Wieland FT. 1996. Science 272:227–34 [Google Scholar]
  159. Arellano M, Durán A, Perez P. 1996. EMBO J. 15:4584–91 [Google Scholar]
  160. Ridley AJ, Hall A. 1992. Cell 70:380–99 [Google Scholar]
  161. Ridley AJ, Paterson HF, Johnston CL, Diekmann D, Hall A. 1992. Cell 70:401–10 [Google Scholar]
  162. Kozma R, Ahmed S, Best A, Lim L. 1995. Mol. Cell. Biol. 81:1159–70 [Google Scholar]
  163. Nobes CD, Hall A. 1995. Cell 81:1–20 [Google Scholar]
/content/journals/10.1146/annurev.biochem.67.1.307
Loading
ROLE OF SMALL G PROTEINS IN YEAST CELL POLARIZATION AND WALL BIOSYNTHESIS1
Annual Review of Biochemistry 67, 307 (1998); https://doi.org/10.1146/annurev.biochem.67.1.307
/content/journals/10.1146/annurev.biochem.67.1.307
/content/journals/10.1146/annurev.biochem.67.1.307
Loading

Data & Media loading...

  • Article Type: Introduction

Most Cited Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error