1932
0
  1. Home
  2. A-Z Publications
  3. Annual Review of Biochemistry
  4. Volume 75, 2006
  5. Article

Annual Review of Biochemistry

Volume 75, 2006

Wanderings of a DNA Enzymologist: From DNA Polymerase to Viral Latency

Abstract

Abstract

I am a member of what has been called, perhaps too grandiosely, “The Greatest Generation.” I grew up during the Great Depression and served in the U.S. Army during World War II. Because of my military service and the benefits of the GI Bill, I was able to attend college and, later, graduate school. Early in my graduate studies, I became fascinated with enzymes and the biochemical reactions that they catalyze. This fascination has never left me during the 50 years I have been a “DNA enzymologist.” I was fortunate to have had as a mentor Arthur Kornberg, one of the great biochemists of the twentieth century, and a splendid group of postdocs and graduate students. I have studied DNA polymerases, DNA nucleases, DNA ligases, and DNA recombinases, enzymes that are critical to our understanding of DNA replication, repair, and recombination. Most recently, I have been studying herpes virus replication and inadvertently wandered into an entirely new area—viral latency.

Keyword(s): Autobiography, DNA ligase, DNA repair, DNA replication, recombination, viruses
Loading

Article metrics loading...

/content/journals/10.1146/annurev.biochem.75.033004.153516
2006-07-07
2024-04-26
Loading full text...

Full text loading...

/deliver/fulltext/bi/75/1/annurev.biochem.75.033004.153516.html?itemId=/content/journals/10.1146/annurev.biochem.75.033004.153516&mimeType=html&fmt=ahah

Literature Cited

  1. Lehman IR, Herriott RM. 1958. J. Gen. Physiol. 41:1067–82
  2. Wyatt GR, Cohen SS. 1953. Biochem. J. 55:744–82
  3. Flaks JG, Cohen SS. 1957. Biochim. Biophys. Acta 25:667–72
  4. Grunberg-Manago M, Ochoa S. 1955. J. Am. Chem. Soc. 77:3165–66
  5. Lehman IR, Bessman MJ, Simms ES, Kornberg A. 1958. J. Biol. Chem. 233:163–70
  6. Bessman MJ, Lehman IR, Simms ES, Kornberg A. 1958. J. Biol. Chem. 233:171–77
  7. Kornberg A. 1957. In The Chemical Basis of Heredity ed. WD McElroy, B Glass pp. 579–608 Baltimore, MD: Johns Hopkins Univ. Press
  8. Watson JD, Crick FHC. 1953. Nature 171:737–39
  9. Lehman IR, Zimmerman SB, Adler J, Bessman MJ, Simms ES, Kornberg A. 1958. Proc. Natl. Acad. Sci. USA 44:1191–96
  10. Chalberg MD, Kelly TJ Jr. 1979. Proc. Natl. Acad. Sci. USA 76:655–59
  11. Schekman R, Wickner W, Westergaard O, Brutlag D, Greider K. et al. 1972. Proc. Natl. Acad. Sci. USA 69:2691–95
  12. Schachman HK, Adler N, Radding CM, Lehman IR, Kornberg A. 1960. J. Biol. Chem. 235:3242–49
  13. Kornberg A, Bertsch L, Jackson JF, Khorana HG. 1964. Proc. Natl. Acad. Sci. USA 51:315–23
  14. Goodman MF. 2002. Annu. Rev. Biochem. 71:17–50
  15. Kornberg A. 1988. J. Biol. Chem. 263:1–4
  16. Lehman IR, Uyemura DG. 1976. Science 193:963–69
  17. Burgers PMJ, Koonin EV, Bruford E, Blanaco L, Burtis KC. et al. 2001. J. Biol. Chem. 276:43487–90
  18. Kuchta RD, Mizrahi V, Benkovic PA, Johnson KA, Benkovic S. 1987. Biochemistry 26:8410–17
  19. Lehman IR. 1960. J. Biol. Chem. 235:1479–87
  20. Schildkraut CL, Marmur J, Doty P. 1961. J. Mol. Biol. 3:595–609
  21. Fiers W, Sinsheimer RL. 1962. J. Mol. Biol. 5:408–17
  22. Lehman IR, Pratt EA. 1960. J. Biol. Chem. 235:3254–59
  23. Kornberg SR, Zimmerman SB, Kornberg A. 1961. J. Biol. Chem. 236:1487–93
  24. Lehman IR. 1971. Annu. Rev. Biochem. 4:251–70
  25. Edgar RS, Denhardt GH, Epstein RH. 1964. Genetics 49:635–46
  26. DeWaard A, Paul AV, Lehman IR. 1965. Proc. Natl. Acad. Sci. USA 54:1241–48
  27. Hall ZW, Lehman IR. 1968. J. Mol. Biol. 36:321–33
  28. De Lucia P, Cairns J. 1969. Nature 224:1164–66
  29. Olivera BM, Lehman IR. 1967. Proc. Natl. Acad. Sci. USA 57:1426–33
  30. Olivera BM, Lehman IR. 1967. Proc. Natl. Acad. Sci. USA 57:1700–4
  31. Lehman IR. 1974. Science 186:790–97
  32. Anraku N, Lehman IR. 1969. J. Mol. Biol. 46:467–79
  33. Konrad EB, Modrich P, Lehman IR. 1974. J. Mol. Biol. 90:115–26
  34. Modrich P, Lehman IR. 1971. Proc. Natl. Acad. Sci. USA 68:1002–5
  35. Lehman IR, Chen JR. 1973. J. Biol. Chem. 248:7502–11
  36. Setlow P, Brutlag D, Kornberg A. 1972. J. Biol. Chem. 247:224–31
  37. Konrad EB, Lehman IR. 1974. Proc. Natl. Acad. Sci. USA 71:2048–51
  38. Uyemura D, Bambara R, Lehman IR. 1975. J. Biol. Chem. 250:8577–84
  39. Lehman IR, Tye BK, Nyman PO. 1979. Cold Spring Harbor Symp. Quant. Biol. 43:221–30
  40. Kriegstein H, Hogness D. 1974. Proc. Natl. Acad. Sci. USA 71:135–39
  41. Banks GR, Boezi JA, Lehman IR. 1979. J. Biol. Chem. 254:9886–92
  42. Conaway RC, Lehman IR. 1982. Proc. Natl. Acad. Sci. USA 79:2523–27
  43. Kaguni LS, Rossignol JM, Conaway RC, Banks GR, Lehman IR. 1983. J. Biol. Chem. 258:9037–39
  44. Schekman R, Weiner A, Kornberg A. 1974. Science 186:987–93
  45. Roberts JW, Roberts CW, Craig NL. 1978. Proc. Natl. Acad. Sci. USA 75:4714–18
  46. Weinstock GM, McEntee K, Lehman IR. 1979. Proc. Natl. Acad. Sci. USA 76:126–30
  47. McEntee K, Weinstock GM, Lehman IR. 1979. Proc. Natl. Acad. Sci. USA 76:2615–19
  48. Scully R, Chen J, Plug A, Xiao Y, Weaver D. et al. 1997. Cell 88:265–75
  49. Lehman IR, Boehmer PE. 1999. J. Biol. Chem. 274:28059–62
  50. Nahmias AJ, Roizman B. 1973. N. Engl. J. Med. 289:781–89
  51. Eom C-Y, Lehman IR. 2003. Proc. Natl. Acad. Sci. USA 100:9803–7
/content/journals/10.1146/annurev.biochem.75.033004.153516
Loading
  • Article Type: Review Article

Most Cited Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error