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Annual Review of Analytical Chemistry

Volume 8, 2015

Advances in Mass Spectrometric Tools for Probing Neuropeptides

Abstract

Neuropeptides are important mediators in the functionality of the brain and other neurological organs. Because neuropeptides exist in a wide range of concentrations, appropriate characterization methods are needed to provide dynamic, chemical, and spatial information. Mass spectrometry and compatible tools have been a popular choice in analyzing neuropeptides. There have been several advances and challenges, both of which are the focus of this review. Discussions range from sample collection to bioinformatic tools, although avenues such as quantitation and imaging are included. Further development of the presented methods for neuropeptidomic mass spectrometric analysis is inevitable, which will lead to a further understanding of the complex interplay of neuropeptides and other signaling molecules in the nervous system.

Keyword(s): mass spectrometric imaging, mass spectrometry, microdialysis, neuropeptidomics, quantitation, sample preparation
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/content/journals/10.1146/annurev-anchem-071114-040210
2015-07-22
2025-04-21
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Advances in Mass Spectrometric Tools for Probing Neuropeptides
Annual Review of Analytical Chemistry 8, 485 (2015); https://doi.org/10.1146/annurev-anchem-071114-040210
/content/journals/10.1146/annurev-anchem-071114-040210
/content/journals/10.1146/annurev-anchem-071114-040210
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