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Annual Review of Analytical Chemistry

Volume 16, 2023

Enhancing the Depth of Analyses with Next-Generation Ion Mobility Experiments

Abstract

Recent developments in ion mobility (IM) technology have expanded the capability to separate and characterize gas-phase ions of biomolecules, especially when paired with mass spectrometry. This next generation of IM technology has been ushered in by creative innovation focused on both instrument architectures and how electric fields are applied. In this review, we focus on the application of high-resolution and multidimensional IM to biomolecular analyses, encompassing the fields of glycomics, lipidomics, peptidomics, and proteomics. We highlight selected research that demonstrates the application of the new IM toolkit to challenging biomolecular systems. Through our review of recently published literature, we outline the current strengths of respective technologies and perspectives for future applications.

Keyword(s): biomolecules, ion mobility, mass spectrometry, molecular identification, multidimensional analysis, structural elucidation
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/content/journals/10.1146/annurev-anchem-091522-031329
2023-06-14
2024-05-04
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/content/journals/10.1146/annurev-anchem-091522-031329
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Enhancing the Depth of Analyses with Next-Generation Ion Mobility Experiments
Annual Review of Analytical Chemistry 16, 27 (2023); https://doi.org/10.1146/annurev-anchem-091522-031329
/content/journals/10.1146/annurev-anchem-091522-031329
/content/journals/10.1146/annurev-anchem-091522-031329
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