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Modern humans are an anomaly in evolution, and the final key features occurred late in human evolution. Ultimate explanations for this evolutionary trajectory are best attained through synthetic studies that integrate genetics, biological anthropology, and archaeology, all resting firmly in the field of evolutionary anthropology. These fields of endeavor typically operate in relative isolation. This synthetic overview identifies the three pillars of human uniqueness: an evolved advanced cognition, hyperprosociality, and psychology for social learning. These properties are foundational for cumulative culture, the dominant adaptation of our species. Although the Homo line evolved in the direction of advancing cognition, the evidence shows that only modern humans evolved extreme levels of prosociality and social learning; this review offers an explanation. These three traits were in place ∼200–100 ka and produced a creature capable of extraordinary social and technological structures, but one that was also empowered to make war in large groups with advanced weapons. The advance out of Africa and the annihilation of other hominin taxa, and many unprepared megafauna, were assured.
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