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Annual Review of Cell and Developmental Biology

Volume 31, 2015

Motors, Anchors, and Connectors: Orchestrators of Organelle Inheritance

Abstract

Organelle inheritance is a process whereby organelles are actively distributed between dividing cells at cytokinesis. Much valuable insight into the molecular mechanisms of organelle inheritance has come from the analysis of asymmetrically dividing cells, which transport a portion of their organelles to the bud while retaining another portion in the mother cell. Common principles apply to the inheritance of all organelles, although individual organelles use specific factors for their partitioning. Inheritance factors can be classified as motors, which are required for organelle transport; anchors, which immobilize organelles at distinct cell structures; or connectors, which mediate the attachment of organelles to motors and anchors. Here, we provide an overview of recent advances in the field of organelle inheritance and highlight how motor, anchor, and connector molecules choreograph the segregation of a multicopy organelle, the peroxisome. We also discuss the role of organelle population control in the generation of cellular diversity.

Keyword(s): organelle division, organelle population control, organelle retention, organelle transport, peroxisomes, Saccharomyces cerevisiae

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2015-11-13
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Motors, Anchors, and Connectors: Orchestrators of Organelle Inheritance
Annual Review of Cell and Developmental Biology 31, 55 (2015); https://doi.org/10.1146/annurev-cellbio-100814-125553
/content/journals/10.1146/annurev-cellbio-100814-125553
/content/journals/10.1146/annurev-cellbio-100814-125553
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Supplementary Data

  • Supplemental Video 1

    Inp1p: an organelle connector that tethers peroxisomes to the cell cortex. Budding yeast cells contain static (anchored) and mobile peroxisomes. Live-cell video microscopy was performed on wild-type cells expressing the peroxisomal matrix protein mCherry-PTS1 and Inp1p-3×GFP. Merged images of the red and green channels are presented. Static peroxisomes contain Inp1p and thus appear yellow, whereas mobile peroxisomes are devoid of Inp1p and appear red.

  • Article Type: Review Article

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