1932

Abstract

This article provides a synopsis of my professional career, from the decision to study chemical engineering to leadership of one of the top academic programs in that field. I describe how I chose to devote my research to phenomena associated with crystallization as practiced for separation and purification and then made the transition to leader of an academic program. Embedded in the coverage are descriptions of research advances coming from exploration of secondary nucleation, especially how collisions of crystals in supersaturated environments dominate the behavior of industrially relevant crystallization processes. I recount some of the challenges associated with becoming a school chair and how the program I led grew. The story illuminates the contributions of my many mentors, colleagues, and students.

Loading

Article metrics loading...

/content/journals/10.1146/annurev-chembioeng-060817-083921
2018-06-07
2024-10-04
Loading full text...

Full text loading...

/deliver/fulltext/chembioeng/9/1/annurev-chembioeng-060817-083921.html?itemId=/content/journals/10.1146/annurev-chembioeng-060817-083921&mimeType=html&fmt=ahah

Literature Cited

  1. 1.  Rousseau RW, Callihan CD, Daly WH 1969. Sulfonyl carbamate derivatives of cellulose. Macromolecules 2:502–7
    [Google Scholar]
  2. 2.  Buckley HE 1951. Crystal Growth. New York: John Wiley & Sons
    [Google Scholar]
  3. 3.  Mullin JW 1961. Crystallization Oxford, UK: Butterworth-Heinemann, 1st ed..
    [Google Scholar]
  4. 4.  Van Hook A 1961. Crystallization New York: Reinhold
    [Google Scholar]
  5. 5.  Mason REA, Strickland-Constable RF 1965. Breeding of crystal nuclei. Trans. R. Soc. 62:455–61
    [Google Scholar]
  6. 6.  Lal DP, Mason REA, Strickland-Constable RF 1969. Collision breeding of crystal nuclei. J. Cryst. Growth 5:1–8
    [Google Scholar]
  7. 7.  Clontz NS, McCabe WL 1971. Contact nucleation of magnesium sulfate heptahydrate. Chem. Eng. Progr. Symp. Ser. No. 110 6:6–17
    [Google Scholar]
  8. 8.  Tai CY, McCabe WL, Rousseau RW 1975. Contact nucleation of various crystal types. AIChE J 21:351–58
    [Google Scholar]
  9. 9.  Tai CY 1974. Contact nucleation of various crystal types PhD Thesis, N.C. State Univ Raleigh:
    [Google Scholar]
  10. 10.  Rousseau RW, McCabe WL, Tai CY 1975. The stability of nuclei generated by contact nucleation. AIChE J 21:1017–19
    [Google Scholar]
  11. 11.  Shah BC, McCabe WL, Rousseau RW 1973. Polyethylene vs. stainless steel impellers for crystallization processes. AIChE J 19:194
    [Google Scholar]
  12. 12.  Bauer LG, Rousseau RW, McCabe WL 1974. Influence of crystal size on the rate of contact nucleation in stirred-tank crystallizers. AIChE J 20:653–59
    [Google Scholar]
  13. 13.  Evans TW, Margolis G, Sarofim AF 1974. Mechanisms of secondary nucleation in agitated crystallizers. AIChE J 20:950–58
    [Google Scholar]
  14. 14.  Gibbs JW 1948. Collected Works New Haven, CT: Yale Univ. Press Crystallization Woburn, MA: Butterworth-Heinmann, 4th ed.].
    [Google Scholar]
  15. 15.  Li H, Kawajiri Y, Grover MA, Rousseau RW 2017. Modeling of nucleation and growth kinetics for unseeded batch cooling crystallization. I&EC Res 56:4060–73
    [Google Scholar]
  16. 16.  Randolph AD, Larson MA 1962. Transient and steady state distributions in continuous mixed suspension crystallizers. AIChE J 8:639–45
    [Google Scholar]
  17. 17.  Randolph AD, Larson MA 1971. Theory of Particulate Processes New York Academic:
    [Google Scholar]
  18. 18.  Rousseau RW, Howell TR 1982. Comparison of simulated crystal size distribution control systems based on nuclei density and supersaturation. Ind. Eng. Chem. Process Des. Dev. 21:606–10
    [Google Scholar]
  19. 19.  McCabe WL 1929. Crystal growth in aqueous solutions. Ind. Eng. Chem. 21:30–33112–19
    [Google Scholar]
  20. 20.  Janse AH, deJong EJ 1976. The occurrence of growth dispersion and its consequences. Industrial Crystallization JW Mullin 145–54 New York: Plenum
    [Google Scholar]
  21. 21.  Randolph AD, White ET 1977. Modeling size dispersion in the prediction of crystal size distribution. Chem. Eng. Sci. 32:1067–76
    [Google Scholar]
  22. 22.  Girolami MW, Rousseau RW 1985. Size-dependent crystal growth—a manifestation of growth rate dispersion in the potassium alum-water system. AIChE J 31:1821–28
    [Google Scholar]
  23. 23.  Berglund KA, Larson MA 1984. Modeling of growth rate dispersion of citric acid monohydrate in continuous crystallizers. AIChE J 30:280–87
    [Google Scholar]
  24. 24.  Zumstein RC, Rousseau RW 1987. Growth rate dispersion in batch crystallization with transient conditions. AIChE J 33:1921–25
    [Google Scholar]
  25. 25.  Zumstein RC, Rousseau RW 1987. Growth rate dispersion by initial growth rate distributions and growth rate fluctuations. AIChE J 33:121–29
    [Google Scholar]
  26. 26.  Zumstein RC, Rousseau RW 1989. Solubility of l-isoleucine in and recovery of l-isoleucine from neutral and acidic aqueous solutions. Ind. Eng. Chem. Res. 28:1226–31
    [Google Scholar]
  27. 27.  Brown MG, Rousseau RW 1994. Effect of sodium hydroxide on the solubilities of l-isoleucine, l-leucine, and l-valine. Biotechnol. Prog. 10:253–57
    [Google Scholar]
  28. 28.  Kurosawa I, Teja AS, Rousseau RW 2005. Solubility measurements in the l-isoleucine + l-valine + water system at 298 K. Ind. Eng. Chem. Res. 44:3284–88
    [Google Scholar]
  29. 29.  Zumstein RC, Rousseau RW 1989. The influence of surfactants on the crystallization of l-isoleucine. Ind. Eng. Chem. Res. 28:334–40
    [Google Scholar]
  30. 30.  Koolman HC, Rousseau RW 1996. Effects of isomorphic compounds on the purity and morphology of l-isoleucine crystals. AIChE J 42:147–53
    [Google Scholar]
  31. 31.  Givand JC, Rousseau RW, Ludovice PJ 1998. Characterization of l-isoleucine crystal morphology from molecular modeling. J. Cryst. Growth 194:228–38
    [Google Scholar]
  32. 32.  Charmolue H, Rousseau RW 1991. l-Serine obtained by methanol addition in batch crystallization. AIChE J 37:1121–28
    [Google Scholar]
  33. 33.  Givand JC, Teja AS, Rousseau RW 1999. Manipulating crystallization variables to enhance crystal purity. J. Cryst. Growth 198/199:1340–44
    [Google Scholar]
  34. 34.  Givand JC, Teja AS, Rousseau RW 2001. Effect of relative solubility on amino acid crystal purity. AIChE J 47:2705–12
    [Google Scholar]
  35. 35.  Givand JC, Chang BK, Teja AS, Rousseau RW 2002. Distribution of isomorphic amino acids between a crystal phase and an aqueous solution. Ind. Eng. Chem. Res. 41:1873–76
    [Google Scholar]
  36. 36.  Teja AS, Givand JC, Rousseau RW 2002. Correlation and prediction of crystal solubility and purity. AIChE J 48:2629–34
    [Google Scholar]
  37. 37.  Kim YS, VanDerveer D, Rousseau RW, Wilkinson AP 2004. Anhydrous sodium naproxen. Acta Cryst E60:m419–20
    [Google Scholar]
  38. 38.  Kim YS, Méndez del Río JR, Rousseau RW 2005. Solubility and prediction of the heat of solution of sodium naproxen in aqueous solutions. J. Pharm. Sci. 94:1941–48
    [Google Scholar]
  39. 39.  Kim YS, Rousseau RW 2004. Characterization and solid-state transformation of the pseudopolymorphic forms of sodium naproxen. Cryst. Growth Des. 4:1211–16
    [Google Scholar]
  40. 40.  Kim YS, Paskow HC, Rousseau RW 2005. Propagation of solid-state transformations by dehydration and stabilization of pseudopolymorphic crystals of sodium naproxen. Cryst. Growth Des. 5:1623–32
    [Google Scholar]
  41. 41.  Chavez KJ, Guevara M, Rousseau RW 2010. Characterization of solvates formed by sodium naproxen and an homologous series of alcohols. Cryst. Growth Des. 10:3372–77
    [Google Scholar]
  42. 42.  Chavez KJ, Rousseau RW 2010. Solubility and pseudopolymorphic transitions in mixed solvents: sodium naproxen in methanol-water and ethanol-water solutions. Cryst. Growth Des. 10:3802–7
    [Google Scholar]
  43. 43.  Svang-Ariyaskul A, Koros WJ, Rousseau RW 2009. Chiral separation using a novel combination of cooling crystallization and membrane barrier: resolution of dl-glutamic acid. Chem. Eng. Sci. 64:1980–84
    [Google Scholar]
  44. 44.  Svang-Ariyaskul A, Koros WJ, Rousseau RW 2012. Chiral purification of glutamic acid enantiomers using a size-selective barrier membrane and dual-vessel crystallization. Chem. Eng. Sci. 77:35–41
    [Google Scholar]
  45. 45.  Lorenz H, Perlberg A, Sapoundjiev D, Elsner MP, Seidel-Morgenstern A 2006. Crystallization of enantiomers. Chem. Eng. Process. Process Intensif. 45:863–73
    [Google Scholar]
  46. 46.  Lorenz H, Polenske D, Seidel-Morgenstern A 2006. Application of preferential crystallization to resolve racemic compounds in a hybrid process. Chirality 18:828–40
    [Google Scholar]
  47. 47.  Encarnación-Gómez LG, Bommarius AS, Rousseau RW 2015. Reactive crystallization of selected enantiomers: chemo-enzymatic stereoinversion of amino acids at supersaturated conditions. Chem. Eng. Sci. 122:416–25
    [Google Scholar]
  48. 48.  Encarnación-Gómez LG, Bommarius AS, Rousseau RW 2016. Reactive crystallization of β-lactam antibiotics: strategies to enhance productivity and purity of ampicillin. React. Chem. Eng. 1:321–29
    [Google Scholar]
  49. 49.  McDonald MA, Bommarius AS, Rousseau RW 2015. Enzymatic reactive crystallization for improving ampicillin synthesis. Chem. Eng. Sci. 165:81–88
    [Google Scholar]
  50. 50.  Felder RM, Rousseau RW 1978. Elementary Principles of Chemical Processes New York: John Wiley & Sons
    [Google Scholar]
  51. 51.  Felder RM, Rousseau RW 1986. Elementary Principles of Chemical Processes New York: John Wiley & Sons, 2nd ed..
    [Google Scholar]
  52. 52.  Felder RM, Rousseau RW 2000. Elementary Principles of Chemical Processes New York: John Wiley & Sons, 3rd ed..
    [Google Scholar]
  53. 53.  Felder RM, Rousseau RW, Bullard LG 2016. Elementary Principles of Chemical Processes New York: John Wiley & Sons, 4th ed..
    [Google Scholar]
  54. 54.  Felder RM, Kelly RM, Ferrell JK, Rousseau RW 1980. How clean gas is made from coal. Environ. Sci. Technol. 14:658–66
    [Google Scholar]
  55. 55.  Rousseau RW 1987. Handbook of Separation Process Technology New York: John Wiley & Sons
    [Google Scholar]
/content/journals/10.1146/annurev-chembioeng-060817-083921
Loading
  • Article Type: Review Article
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error