1932

Abstract

I profile my personal and professional journey from being a girl of the 1950s, with expectations typical for the times, to a chemical engineering professor and still-enthusiastic researcher. I describe my family, my early education, my college and graduate school training in physics, my postdoc years in chemistry, and my subsequent transformation into a chemical engineering faculty member—one of the first women to be appointed to a chemical engineering faculty in the United States. I focus on the events that shaped me, the people who noticed and supported me, and the environment for women scientists and engineers in what some would call the “early days.” My initial research activities centered on applications of statistical mechanics to predict phase equilibria in simple systems. Over time, my interests evolved to focus on applying molecule-level computer simulations to systems of interest to chemical engineers, e.g., hydrocarbons and polymers. Eventually, spurred on by my personal interest in amyloid diseases and my wish to make a contribution to human health, I turned to more biologically oriented problems having to do with protein aggregation and protein design. I give a candid assessment of my strengths and weaknesses, successes and failures. Finally, I share the most valuable lessons that I have learned over a lifetime of professional and personal experience.

Loading

Article metrics loading...

/content/journals/10.1146/annurev-chembioeng-101519-120354
2020-06-07
2024-06-21
Loading full text...

Full text loading...

/deliver/fulltext/chembioeng/11/1/annurev-chembioeng-101519-120354.html?itemId=/content/journals/10.1146/annurev-chembioeng-101519-120354&mimeType=html&fmt=ahah

Literature Cited

  1. 1. 
    Stanley HE 1987. Introduction to Phase Transitions and Critical Phenomena Oxford, UK: Oxford Univ. Press
    [Google Scholar]
  2. 2. 
    Gilbert S 2017. The movement of #MeToo: how a hashtag got its power. The AtlanticOct. 16
    [Google Scholar]
  3. 3. 
    Ciach A, Hall CK, Kahl G, Lomba E 2016. George Stell (1933–2014). J. Phys. Condens. Matter 28:410401
    [Google Scholar]
  4. 4. 
    Stell G, Narang H, Hall CK 1972. Simple lattice gas with realistic phase changes. Phys. Rev. Lett. 28:29294
    [Google Scholar]
  5. 5. 
    Hall CK, Stell G 1973. Phase transitions in two-dimensional lattice gases of hard core molecules with weak, long-range attractions. Phys. Rev. A 7:167989
    [Google Scholar]
  6. 6. 
    Hall CK, Stell G 1975. Decorated lattice model of a metamagnetic or host-impurity system. Phys. Rev. B 11:22438
    [Google Scholar]
  7. 7. 
    Hall CK 1975. Scaling in the ideal Bose gas. J. Stat. Phys. 13:157–72
    [Google Scholar]
  8. 8. 
    Reed TM, Gubbins KE 1973. Applied Statistical Mechanics: Thermodynamics and Transport Properties of Fluids Chem. Eng. Ser. Oxford, UK: Butterworth-Heinemann
    [Google Scholar]
  9. 9. 
    Kalos MH, Whitlock PA 2008. Monte Carlo Methods Hoboken, NJ: Wiley 2nd ed.
    [Google Scholar]
  10. 10. 
    Futran M, Coats SG, Hall CK, Welch DO 1982. The phase-change behavior of hydrogen in niobium and in niobium-vanadium alloys. J. Chem. Phys. 77:622335
    [Google Scholar]
  11. 11. 
    Shirley AI, Hall CK, Prince NJ 1983. Trapping of hydrogen by oxygen and nitrogen impurities in niobium, vanadium and tantalum. Acta Metall 31:985–92
    [Google Scholar]
  12. 12. 
    Soteros CE, Hall CK 1990. Niobium hydride phase behavior studies using the cluster variation method. Phys. Rev. B Condens. Matter 42:6590
    [Google Scholar]
  13. 13. 
    Asakura S, Oosawa F 1954. On interaction between two bodies immersed in a solution of macromolecules. J. Chem. Phys. 22:125556
    [Google Scholar]
  14. 14. 
    Gast AP, Hall CK, Russel WB 1983. Polymer induced phase separations in nonaqueous colloidal suspensions. J. Colloid Interface Sci. 96:251–67
    [Google Scholar]
  15. 15. 
    Rosenbaum D, Zamora PC, Zukoski CF 1996. Phase behavior of small attractive colloidal particles. Phys. Rev. Lett 76:15053
    [Google Scholar]
  16. 16. 
    tenWolde PR, Frenkel D 1997. Enhancement of protein crystal nucleation by critical density fluctuations. Science 277:1975–78
    [Google Scholar]
  17. 17. 
    Gast AP, Russel WB, Hall CK 1986. An experimental and theoretical study of phase transitions in the polystyrene latex and hydroxyethylcellulose system. J. Colloid Interface Sci. 109:161–71
    [Google Scholar]
  18. 18. 
    Hall CK, Helfand E. 1982. Conformational state relaxation in polymers: time correlation functions. J. Chem. Phys. 77:327582
    [Google Scholar]
  19. 19. 
    Dickman R, Hall CK 1986. Equation of state for chain molecules: continuous-space analog of Flory theory. J. Chem. Phys. 85:410815
    [Google Scholar]
  20. 20. 
    Honnell KG, Hall CK 1989. A new equation of state for athermal chains. J. Chem. Phys. 90:184155
    [Google Scholar]
  21. 21. 
    Wichert JM, Hall CK 1994. Generalized Flory equation of state for chain-monomer mixtures of unequal segment sizes. Chem. Eng. Sci. 49:2793804
    [Google Scholar]
  22. 22. 
    Gulati H, Wichert JM, Hall CK 1996. Generalized Flory equations of state for hard heteronuclear chain molecules. J. Chem. Phys. 104:522033
    [Google Scholar]
  23. 23. 
    Yethiraj A, Hall CK 1990. Monte Carlo simulation of polymers confined between flat plates. Macromolecules 23:1865–72
    [Google Scholar]
  24. 24. 
    Yethiraj A, Hall CK 1991. Integral–equation theory for the adsorption of chain fluids in slit-like pores. J. Chem. Phys. 95:374955
    [Google Scholar]
  25. 25. 
    Chapman WG, Gubbins KE, Jackson G, Radosz M 1989. SAFT: equation of state solution model for associating fluids. Fluid Phase Equilib 52:31–38
    [Google Scholar]
  26. 26. 
    Knowles TPJ, Vendruscolo M, Dobson CM 2014. The amyloid state and its association with protein misfolding diseases. Nat. Rev. Mol. Cell Biol. 15:384–96
    [Google Scholar]
  27. 27. 
    Nguyen HD, Hall CK 2004. Molecular dynamics simulations of spontaneous fibril formation by random-coil peptides. PNAS 101:1618085
    [Google Scholar]
  28. 28. 
    Forood B, Perezpaya E, Houghten RA, Blondelle SE 1995. Formation of an extremely stable polyalanine β-sheet macromolecule. Biochem. Biophys. Res. Commun. 211:7–13
    [Google Scholar]
  29. 29. 
    Cheon M, Chang I, Hall CK 2010. Extending the PRIME model for protein aggregation to all twenty amino acids. Proteins 78:295060
    [Google Scholar]
  30. 30. 
    Cheon M, Hall CK, Chang I 2015. Structural conversion of Aβ17–42 peptides from disordered oligomers to U-shape protofilaments via multiple kinetic pathways. PLOS Comput. Biol. 11:e1004258
    [Google Scholar]
  31. 31. 
    Wang Y, Latshaw DC, Hall CK 2017. Aggregation of Aβ(17–36) in the presence of naturally occurring phenolic inhibitors using coarse-grained simulations. J. Mol. Biol. 429:3893–908
    [Google Scholar]
  32. 32. 
    Bunce SJ, Wang Y, Stewart KL, Ashcroft AE, Radford SE et al. 2019. Molecular insights into the surface-catalyzed secondary nucleation of amyloid-β(40) by the peptide fragment Aβ(16–22). Sci. Adv. 5:eaav8216
    [Google Scholar]
  33. 33. 
    Wang Y, Bunce SJ, Radford SE, Wilson AJ, Auer S, Hall CK 2019. Thermodynamic phase diagram of amyloid-β (16–22) peptide. PNAS 116:209196
    [Google Scholar]
  34. 34. 
    Xiao X, Agris PF, Hall CK 2015. Designing peptide sequences in flexible chain conformations to bind RNA: a search algorithm combining Monte Carlo, self-consistent mean field and concerted rotation techniques. J. Chem. Theory Comput. 11:740–52
    [Google Scholar]
  35. 35. 
    Spears J, Xiao X, Hall CK, Agris P 2014. Amino acid signature enables proteins to recognize tRNA. Biochemistry 53:1125–33
    [Google Scholar]
  36. 36. 
    Xiao X, Kuang Z, Slocik JM, Tadepalli S, Mirau PA et al. 2018. Advancing peptide-based biorecognition elements for biosensors using in-silico evolution. ACS Sens 3:1024–31
    [Google Scholar]
/content/journals/10.1146/annurev-chembioeng-101519-120354
Loading
/content/journals/10.1146/annurev-chembioeng-101519-120354
Loading

Data & Media loading...

  • Article Type: Review Article
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error