1932

Abstract

Mitochondria play key roles in activating apoptosis in mammalian cells. Bcl-2 family members regulate the release of proteins from the space between the mitochondrial inner and outer membrane that, once in the cytosol, activate caspase proteases that dismantle cells and signal efficient phagocytosis of cell corpses. Here we review the extensive literature on proteins released from the intermembrane space and consider genetic evidence for and against their roles in apoptosis activation. We also compare and contrast apoptosis pathways in , , and mammals that indicate major mysteries remaining to be solved.

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/content/journals/10.1146/annurev-genet-102108-134850
2009-12-01
2024-04-15
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  • Article Type: Review Article
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