1932

Abstract

The molecular genetic analysis of longevity of has yielded fundamental insights into evolutionarily conserved pathways and processes governing the physiology of aging. Recent studies suggest that interactions between and its microbial environment may influence the aging and longevity of this simple host organism. Experimental evidence supports a role for bacteria in affecting longevity through distinct mechanisms—as a nutrient source, as a potential pathogen that induces double-edged innate immune and stress responses, and as a coevolved sensory stimulus that modulates neuronal signaling pathways regulating longevity. Motivating this review is the anticipation that the molecular genetic dissection of the integrated host immune, stress, and neuroendocrine responses to microbes in will uncover basic insights into the cellular and organismal physiology that governs aging and longevity.

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/content/journals/10.1146/annurev-genet-111212-133352
2013-11-23
2024-06-17
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  • Article Type: Review Article
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