1932

Abstract

The molecular genetic analysis of longevity of has yielded fundamental insights into evolutionarily conserved pathways and processes governing the physiology of aging. Recent studies suggest that interactions between and its microbial environment may influence the aging and longevity of this simple host organism. Experimental evidence supports a role for bacteria in affecting longevity through distinct mechanisms—as a nutrient source, as a potential pathogen that induces double-edged innate immune and stress responses, and as a coevolved sensory stimulus that modulates neuronal signaling pathways regulating longevity. Motivating this review is the anticipation that the molecular genetic dissection of the integrated host immune, stress, and neuroendocrine responses to microbes in will uncover basic insights into the cellular and organismal physiology that governs aging and longevity.

Loading

Article metrics loading...

/content/journals/10.1146/annurev-genet-111212-133352
2013-11-23
2024-12-12
Loading full text...

Full text loading...

/content/journals/10.1146/annurev-genet-111212-133352
Loading
/content/journals/10.1146/annurev-genet-111212-133352
Loading

Data & Media loading...

  • Article Type: Review Article
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error