1932

Abstract

Mobile genetic elements have the ability to move between positions in a genome. Some of these elements are capable of targeting one of the template strands during DNA replication. Examples found in bacteria include () Red recombination mediated by bacteriophage λ, () integration of group II mobile introns that reverse splice and reverse transcribe into DNA, () HUH endonuclease elements that move as single-stranded DNA, and () Tn, a DNA cut-and-paste transposon that uses a target-site-selecting protein to target transposition into certain forms of DNA replication. In all of these examples, the lagging-strand template appears to be targeted using a variety of features specific to this strand. These features appear especially available in certain situations, such as when replication forks stall or collapse. In this review, we address the idea that features specific to the lagging-strand template represent vulnerabilities that are capitalized on by mobile genetic elements.

Loading

Article metrics loading...

/content/journals/10.1146/annurev-genet-120213-092046
2014-11-23
2025-02-10
Loading full text...

Full text loading...

/content/journals/10.1146/annurev-genet-120213-092046
Loading
/content/journals/10.1146/annurev-genet-120213-092046
Loading

Data & Media loading...

  • Article Type: Review Article
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error