Role of Cell Death in Toxicology: Does It Matter How Cells Die?

Literature Cited

1. 1.  Klingenberg M 1958. Pigments of rat liver microsomes. Arch. Biochem. Biophys. 75:376–86
   [Google Scholar]
2. 2.  Estabrook RW, Cooper DY, Rosenthal O 1963. The light reversible carbon monoxide inhibition of the steroid C21-hydroxylase system of the adrenal cortex. Biochem. Z. 338:741–55
   [Google Scholar]
3. 3.  Axelrod J 1963. The discovery of the microsomal drug-metabolizing enzymes. Trends Pharmacol. Sci. 3:383–86
   [Google Scholar]
4. 4.  Orrenius S 1965. On the mechanism of drug hydroxylation in rat liver microsomes. J. Cell Biol. 26:713–23
   [Google Scholar]
5. 5.  Orrenius S, Ericsson JLE, Ernster L 1965. Phenobarbital-induced synthesis of the microsomal drug-metabolizing enzyme system and its relationship to the proliferation of endoplasmic membranes. J. Cell Biol. 25:627–39
   [Google Scholar]
6. 6.  Orrenius S 1965. Further studies on the induction of the drug-hydroxylating enzyme system of liver microsomes. J. Cell Biol. 26:725–33
   [Google Scholar]
7. 7.  Zeidenberg P, Orrenius S, Ernster L 1967. Increase in levels of glucuronylating enzymes and associated rise in activities of mitochondrial oxidative enzymes upon phenobarbital administration in the rat. J. Cell Biol. 32:528–31
   [Google Scholar]
8. 8.  Ellin C, Jakobsson SW, Schenkman JB, Orrenius S 1972. Cytochrome P450K of rat kidney cortex microsomes: its involvement in fatty acid ω- and (ω-1)-hydroxylation. Arch. Biochem. Biophys. 150:64–71
   [Google Scholar]
9. 9.  Moldéus P, Grundin R, Vadi H, Orrenius S 1974. A study of drug metabolism linked to cytochrome P-450 in isolated rat liver cells. Eur. J. Biochem. 46:351–60
   [Google Scholar]
10. 10.  Vadi H, Moldéus P, Capdevila J, Orrenius S 1975. The metabolism of benzo(a)pyrene in isolated rat liver cells. Cancer Res 35:2083–91
    [Google Scholar]
11. 11.  Jones DP, Moldéus P, Stead AH, Ormstad K, Jörnvall H, Orrenius S 1979. Metabolism of glutathione and a glutathione conjugate by isolated kidney cells. J. Biol. Chem. 254:2787–92
    [Google Scholar]
12. 12.  Jones DP, Thor H, Andersson B, Orrenius S 1978. Detoxification reactions in isolated hepatocytes. Role of glutathione peroxidase, catalase and formaldehyde dehydrogenase in reactions relating to N-demethylation by the cytochrome P-450 system. J. Biol. Chem. 253:6031–37
    [Google Scholar]
13. 13.  Mitchell JR, Jollow DJ, Gillette JR, Brodie BB 1973. Drug metabolism as a cause of drug toxicity. Drug Metab. Dispos. 1:418–23
    [Google Scholar]
14. 14.  Thor H, Moldéus P, Hermanson R, Högberg J, Reed DJ, Orrenius S 1978. Metabolic activation and hepatotoxicity. Toxicity of bromobenzene in hepatocytes isolated from phenobarbital- and diethylmaleate-treated rats. Arch. Biochem. Biophys. 188:122–29
    [Google Scholar]
15. 15.  Smith MT, Thor H, Orrenius S 1981. Toxic injury to isolated hepatocytes is not dependent on extracellular calcium. Science 213:1257–59
    [Google Scholar]
16. 16.  Thor H, Smith MT, Hartzell P, Bellomo G, Jewell S, Orrenius S 1982. The metabolism of menadione (2-methyl-1,4-naphthoquinone) by isolated hepatocytes. A study of the implications of oxidative stress in intact cells. J. Biol. Chem. 257:12419–25
    [Google Scholar]
17. 17.  Bellomo G, Jewell S, Orrenius S 1982. The metabolism of menadione impairs the ability of rat liver mitochondria to take up and retain calcium. J. Biol. Chem. 257:11558–62
    [Google Scholar]
18. 18.  Thor H, Hartzell P, Orrenius S 1984. Potentiation of oxidative cell injury in hepatocytes which have accumulated Ca²⁺. J. Biol. Chem. 259:6612–15
    [Google Scholar]
19. 19.  Fleckenstein A, Janke J, Doring HJ, Leder O 1974. Myocardial fiber necrosis due to intracellular Ca overload—a new principle in cardiac pathophysiology. Recent Adv. Stud. Cardiac. Struct. Metab. 4:563–80
    [Google Scholar]
20. 20.  Jones DP, Thor H, Smith MT, Jewell S, Orrenius S 1983. Inhibition of ATP-dependent microsomal Ca²⁺ sequestration during oxidative stress and its prevention by glutathione. J. Biol. Chem. 258:6390–93
    [Google Scholar]
21. 21.  Jewell S, Bellomo G, Thor H, Orrenius S, Smith MT 1982. Bleb formation in hepatocytes during drug metabolism is caused by disturbances in thiol and calcium ion homeostasis. Science 217:1257–59
    [Google Scholar]
22. 22.  Nicotera P, McConkey DJ, Jones DP, Orrenius S 1989. ATP stimulates Ca²⁺ uptake and increases the free Ca²⁺ concentration in isolated rat liver nuclei. PNAS 86:453–57
    [Google Scholar]
23. 23.  Jones DP, McConkey DJ, Nicotera P, Orrenius S 1989. Calcium-activated DNA fragmentation in rat liver nuclei. J. Biol. Chem. 264:6398–403
    [Google Scholar]
24. 24.  Kerr JF, Wyllie AH, Currie AR 1972. Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. Br. J. Cancer 26:239–57
    [Google Scholar]
25. 25.  McConkey DJ, Nicotera P, Hartzell P, Bellomo G, Wyllie AH, Orrenius S 1989. Glucocorticoids activate a suicide process in thymocytes through an elevation of cytosolic Ca²⁺ concentration. Arch. Biochem. Biophys. 269:365–70
    [Google Scholar]
26. 26.  Wyllie AH 1980. Glucocorticoid-induced apoptosis is associated with endogenous endonuclease activation. Nature 284:555–56
    [Google Scholar]
27. 27.  Nicotera P, Bellomo G, Orrenius S 1992. Calcium-mediated mechanisms in chemically induced cell death. Annu. Rev. Pharmacol. Toxicol. 32:449–70
    [Google Scholar]
28. 28.  Schlegel J, Peters I, Orrenius S, Miller DK, Thornberry NA et al. 1996. CPP32/Apopain is a key interleukin 1ß-converting enzyme-like protease involved in Fas-mediated apoptosis. J. Biol. Chem. 271:1841–44
    [Google Scholar]
29. 29.  Robertson JD, Gogvadze V, Kropotov A, Vakifahmetoglu H, Zhivotovsky B, Orrenius S 2004. Processed caspase-2 can induce mitochondria-mediated apoptosis independently of its enzymatic activity. EMBO Rep 5:643–48
    [Google Scholar]
30. 30.  Vakifahmetoglu H, Olsson M, Orrenius S, Zhivotovsky B 2006. Functional connection between p53 and caspase-2 is essential for apoptosis induced by DNA damage. Oncogene 25:5683–92
    [Google Scholar]
31. 31.  Slater AFG, Nobel CSI, den Dobbelsteen DJ, Orrenius S 1996. Intracellular redox changes during apoptosis. Cell Death Differ 3:57–62
    [Google Scholar]
32. 32.  Li P, Nijhawan D, Budihardjo I, Srinivasula SM, Ahmad M et al. 1997. Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade. Cell 91:479–89
    [Google Scholar]
33. 33.  Zhivotovsky B, Orrenius S, Brustugun OT, Døskeland SO 1998. Injected cytochrome c induces apoptosis. Nature 391:449–50
    [Google Scholar]
34. 34.  Brustugun OT, Fladmark KE, Døskeland SO, Orrenius S, Zhivotovsky B 1998. Apoptosis induced by microinjection of cytochrome c is caspase-dependent and is inhibited by Bcl-2. Cell Death Diff 5:660–68
    [Google Scholar]
35. 35.  Gogvadze V, Robertson JD, Zhivotovsky B, Orrenius S 2001. Cytochrome c release occurs via Ca²⁺-dependent and Ca²⁺-independent mechanisms that are regulated by Bax. J. Biol. Chem. 276:19066–71
    [Google Scholar]
36. 36.  Ott M, Robertson JD, Gogvadze V, Zhivotovsky B, Orrenius S 2002. Cytochrome c release from mitochondria proceeds by a two-step process. PNAS 99:1259–63
    [Google Scholar]
37. 37.  Kagan VE, Tyurin VA, Jiang J, Tyurina YY, Ritov VB et al. 2005. Cytochrome c acts as a cardiolipin oxygenase required for release of proapoptotic factors. Nat. Chem. Biol. 1:223–32
    [Google Scholar]
38. 38.  Susin SA, Lorenzo HK, Zamzami N, Marzo I, Snow BE et al. 1999. Molecular characterization of mitochondrial apoptosis-inducing factor. Nature 397:441–46
    [Google Scholar]
39. 39.  Norberg E, Gogvadze V, Ott M, Horn M, Uhlén P et al. 2008. An increase in intracellular Ca²⁺ is required for the activation of mitochondrial calpain to release AIF during cell death. Cell Death Differ 15:1857–64
    [Google Scholar]
40. 40.  Norberg E, Karlsson M, Korenovska O, Szydlowski S, Silberberg G et al. 2010. Critical role for hyperpolarization-activated cyclic nucleotide-gated channel 2 in the AIF-mediated apoptosis. EMBO J 29:3869–78
    [Google Scholar]
41. 41.  Norberg E, Gogvadze V, Vakifahmetoglu H, Orrenius S, Zhivotovsky B 2010. Oxidative modification sensitizes mitochondrial apoptosis-inducing factor to calpain-mediated processing. Free Radic. Biol. Med. 48:791–97
    [Google Scholar]
42. 42.  Orrenius S, Kaminskyy VO, Zhivotovsky B 2013. Autophagy in toxicology: cause or consequence?. Annu. Rev. Pharmacol. Toxicol. 53:275–97
    [Google Scholar]
43. 43.  Dypbukt JM, Ankarcrona M, Burkitt M, Sjöholm C, Ström K et al. 1994. Different prooxidant levels stimulate growth, trigger apoptosis, or produce necrosis of insulin-secreting RINm5F cells. J. Biol. Chem. 269:30553–60
    [Google Scholar]
44. 44.  McConkey DJ, Hartzell P, Duddy SK, Håkansson H, Orrenius S 1988. 2,3,7,8-Tetrachlorodibenzo-p-dioxin kills immature thymocytes by Ca²⁺-mediated endonuclease activation. Science 242:256–59
    [Google Scholar]
45. 45.  Ankarcrona M, Dypbukt JM, Bonfoco E, Zhivotovsky B, Orrenius S et al. 1995. Glutamate-induced neuronal death: a succession of necrosis or apoptosis depending on mitochondrial function. Neuron 15:961–73
    [Google Scholar]
46. 46.  Orrenius S, Zhivotovsky B, Nicotera P 2003. Regulation of cell death: the calcium-apoptosis link. Nat. Rev. Mol. Cell. Biol. 4:552–65
    [Google Scholar]
47. 47.  Orrenius S, Gogvadze V, Zhivotovsky B 2007. Mitochondrial oxidative stress: implications for cell death. Annu. Rev. Pharmacol. Toxicol. 47:143–83
    [Google Scholar]