1932

Abstract

Neurotransmitter identity is a defining feature of all neurons because it constrains the type of information they convey, but many neurons release multiple transmitters. Although the physiological role for corelease has remained poorly understood, the vesicular uptake of one transmitter can regulate filling with the other by influencing expression of the H+ electrochemical driving force. In addition, the sorting of vesicular neurotransmitter transporters and other synaptic vesicle proteins into different vesicle pools suggests the potential for distinct modes of release. Corelease thus serves multiple roles in synaptic transmission.

Loading

Article metrics loading...

/content/journals/10.1146/annurev-physiol-020911-153315
2012-03-17
2024-04-21
Loading full text...

Full text loading...

/content/journals/10.1146/annurev-physiol-020911-153315
Loading
/content/journals/10.1146/annurev-physiol-020911-153315
Loading

Data & Media loading...

  • Article Type: Review Article
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error