1932

Abstract

The recent identification of proteins that recognize origins of DNA replication and control the initiation of eukaryotic DNA replication has provided critical molecular tools to dissect this process. Dynamic changes in the assembly and disassembly of protein complexes at origins are important for the initiation of DNA replication and occur throughout the cell cycle. Herein, we review the key proteins required for the initiation of DNA replication, their involvement in the protein complex assembly at replication origins, and how the cell cycle machinery regulates this process.

Loading

Article metrics loading...

/content/journals/10.1146/annurev.cellbio.13.1.293
1997-11-01
2024-12-11
Loading full text...

Full text loading...

/content/journals/10.1146/annurev.cellbio.13.1.293
Loading
/content/journals/10.1146/annurev.cellbio.13.1.293
Loading

Data & Media loading...

  • Article Type: Review Article
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error